2016
DOI: 10.1128/aem.01437-16
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Effects of Proton Pump Inhibitors on the Gastric Mucosa-Associated Microbiota in Dyspeptic Patients

Abstract: Besides being part of anti-Helicobacter pylori treatment regimens, proton pump inhibitors (PPIs) are increasingly being used to treat dyspepsia. However, little is known about the effects of PPIs on the human gastric microbiota, especially those related to H. pylori infection. The goal of this study was to characterize the stomach microbial communities in patients with dyspepsia and to investigate their relationships with PPI use and H. pylori status. Using 16S rRNA gene pyrosequencing, we analyzed the mucosa-… Show more

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Cited by 84 publications
(94 citation statements)
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“…But similar to the salivary samples, the PPI group exhibited greater phylogenetic diversity of the gastric fluid microbiome, based on unweighted UniFrac distances, while weighted UniFrac distances did not differ significantly . In a cohort of 24 adults undergoing upper gastrointestinal endoscopy for evaluation of dyspepsia, long‐term intake of PPIs in 12 patients was not associated with alterations in species richness or diversity indices, but with increased abundance of the phylum Firmicutes, family Streptococcaceae and genus Streptococcus , independently of H pylori status …”
Section: Resultsmentioning
confidence: 96%
“…But similar to the salivary samples, the PPI group exhibited greater phylogenetic diversity of the gastric fluid microbiome, based on unweighted UniFrac distances, while weighted UniFrac distances did not differ significantly . In a cohort of 24 adults undergoing upper gastrointestinal endoscopy for evaluation of dyspepsia, long‐term intake of PPIs in 12 patients was not associated with alterations in species richness or diversity indices, but with increased abundance of the phylum Firmicutes, family Streptococcaceae and genus Streptococcus , independently of H pylori status …”
Section: Resultsmentioning
confidence: 96%
“…It should be noted that when detected using conventional methods, H pylori comprises a significant proportion of the ecosystem often representing over 90% of bacteria. Reduced microbial diversity of the gastric microbiota and decreased abundance of other microbial groups is well documented in the case of H pylori colonisation . However, this seems to be a reversible situation.…”
Section: Resultsmentioning
confidence: 99%
“…The first question of clinical relevance is whether PPIs exert any effect on the gastric bacterial communities, and this was investigated in a study by Williams and collaborators that was still solely based on culturable gastric bacteria28. More recently, next-generation-sequencing-based metagenomic studies further confirmed that PPIs modify the gastroenteric human microbiota2930313233.…”
Section: Resultsmentioning
confidence: 99%