1997
DOI: 10.1016/s0271-5317(97)00157-7
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Effects of protein malnutrition on liver cytochrome p450s

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Cited by 8 publications
(6 citation statements)
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“…Many experimental studies have shown that protein malnutrition reduces the CYPs activity including CYP3A, CYP2C isoform, and so on. [12][13][14] Hence, mild increase in free PHT in undernourished patients with wild genotype of CYP2C9 (G4 group) could be the result of reduction in the CYP2C9 enzymatic activity in addition to PHT's saturable nonlinear elimination.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Many experimental studies have shown that protein malnutrition reduces the CYPs activity including CYP3A, CYP2C isoform, and so on. [12][13][14] Hence, mild increase in free PHT in undernourished patients with wild genotype of CYP2C9 (G4 group) could be the result of reduction in the CYP2C9 enzymatic activity in addition to PHT's saturable nonlinear elimination.…”
Section: Discussionmentioning
confidence: 99%
“…[3][4][5][6] Many reports suggest that undernutrition, which is commonly prevalent in developing countries, may lead to changes in the activity of cytochrome P450-dependent mixed function oxidase [7][8][9][10] and it decreases the activities of CYP3A, CYP2C isoform. [11][12][13][14] Several pharmacogenetic studies have shown that genetic defects in drug-metabolizing enzyme of CYP2C9 affect phenytoin kinetics. [15][16][17][18][19] CYP2C9*2 and CYP2C9*3 are the two most common allelic variants that result in significant reduction in the metabolism of PHT.…”
Section: Introductionmentioning
confidence: 99%
“…This substantial effect on CYP3A2 activity is in agreement with previous results in our laboratory in which we observed a marked reduction in CYP3A2-mediated ifosfamide N-dechloroethylation (37) as well as the results of Lee et ai. (18) studying progesterone 6~-hydroxylation. Interestingly, the K m for dextromethorphan O-demethylation (CYP2DI) decreased in PCM animals, similar to that seen with CYP2El.…”
Section: Discussionmentioning
confidence: 99%
“…Using testosterone metabolism as a general screen for differential effects of PCM on cytochrome P450 oxidations, we have shown that the metabolism of most testosterone metabolites is reduced but that some remain unaffected by PCM, suggesting differential effects on various P450 isoforms (17). Finally, Lee et al (18) have recently demonstrated that PCM had no effect on CYPIAI expression, little effect on CYPIA2 and a pronounced effect on CYP3A expression. Furthermore, these authors demonstrated that CYP3A activity was substantially reduced by PCM.…”
Section: Introductionmentioning
confidence: 96%
“…Protein malnutrition can affect the pathways of acetaminophen metabolism [5][6][7]. Acetaminophen is metabolized by different pathways such as sulfation, glucuronidation, and some isoforms of hepatic microsomal cytochrome P450s, such as CYP1A2 and CYP3A.…”
Section: Introductionmentioning
confidence: 99%