Effects of Protein Depletion and Repletion on Experimental Open Wound Contraction

Modolin, Miguel; Rg, Bevilacqua; Nf, Margarido; Lima-Gonçalves, E

doi:10.1097/00000637-198508000-00005

Cited by 9 publications

(2 citation statements)

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“…The process of wound healing is anabolic and requires additional calorific intake [11]. Protein depletion has been shown in rats to increase the risk of wound dehiscence [12]. Obesity is associated with poor wound healing independent of glycemic control.…”

Section: Remodeling: 3 Weeks-2 Yearsmentioning

confidence: 99%

Basic Surgical Techniques

Mosahebi

Woollard

2013

Atlas of Male Genitourethral Surgery

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Section: Remodeling: 3 Weeks-2 Yearsmentioning

confidence: 99%

Basic Surgical Techniques

Mosahebi

Woollard

2013

Atlas of Male Genitourethral Surgery

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“…Others indicated that incised/sutured wound healing was delayed in rats with hypoproteinaemia, and that protein correction achieved as rapidly as possible normalised the tensile strength (10). In addition, the tensile strength was attenuated in rats fed on a protein‐free diet (11), and protein deficiency reduced myofibroblast activity (12). These studies suggest the marked influence of protein on wound healing; healing is delayed in the presence of hypoproteinaemia, and protein correction should be performed as promptly as possible.…”

Section: Introductionmentioning

confidence: 99%

Influence of the timing of switching a protein‐free to a protein‐containing diet on the wound healing process in a rat all‐layer skin defect

Tsuda

Nakatani²,

Sugama

et al. 2010

International Wound Journal

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We prepared full thickness skin defects in rats fed a protein-free diet as a hypoproteinemia model, then switched the animals to a diet containing a normal protein level 1, 6, or 12 days after wounding (inflammatory, granulation, and rearrangement phases of the wound healing process) to examine whether improvement in the low-protein state promotes subsequent wound healing. The interval until wound healing in rats fed a normal protein diet was significantly shorter, while that in rats continuously fed a protein-free diet was significantly longer than those of other groups. Early correction tended to accelerate wound healing. Although wound contraction in groups receiving a protein-corrected or protein-free diet remained similar until 15 days after wounding, thereafter the duration of the rearrangement phase was significantly longer in the protein-free group than in the other groups. The collagen level per unit of granulation tissue area during wound healing was significantly lower in the protein-free group than in the other groups. These findings indicate that protein correction at any time after wounding accelerates wound healing, although early correction is more effective, and reduces the duration of the rearrangement phase more than those of the inflammatory and granulation phases due to the deposit of collagen.

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Wounds: Biology, Pathology, and Management

Lorenz

Longaker

2008

Surgery

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Effects of Protein Depletion and Repletion on Experimental Open Wound Contraction

Cited by 9 publications

References 0 publications

Basic Surgical Techniques

Basic Surgical Techniques

Influence of the timing of switching a protein‐free to a protein‐containing diet on the wound healing process in a rat all‐layer skin defect

Wounds: Biology, Pathology, and Management

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