Effects of prostaglandin administration on ovarian follicular dynamics, conception, prolificacy, and fecundity in sheep

Fierro, S.; Olivera-Muzante, J.; Gil, J.; Viñoles, C.

doi:10.1016/j.theriogenology.2011.03.016

Cited by 36 publications

(17 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The first-wave model is effective in that regard, but the low progesterone concentrations produced by a newly formed and short-life corpus luteum may create an abnormal endocrine milieu (e.g. increased LH pulse frequency) with negative consequences for the development of the pre-ovulatory follicle, the competence of the oocyte and fertility (Sirois & Fortune 1990, Viñ oles et al 2001, 2012, Fierro et al 2011. The development of an alternative approach for synchronising the emergence of waves of follicles during the luteal phase might be useful; therefore, for testing whether changes in the E 2 -FSH feedback loop is indeed an effect of nutrition or a consequence of the 'first-wave' model.…”

Section: Nutrition and Follicle Development In Merino Ewesmentioning

confidence: 99%

Follicle development, endocrine profiles and ovulation rate in adult Merino ewes: effects of early nutrition (pre- and post-natal) and supplementation with lupin grain

et al. 2014

View full text Add to dashboard Cite

In adult ewes, we tested whether ovarian function, including the response to short-term supplementation, was affected by the nutrition of their mothers during the pre-/post-natal period. A 2!2 factorial design was used with nutrition in early life (low or high) and a 6-day supplement (with or without) as factors. All ewes received three prostaglandin (PG) injections 7 days apart, and the supplement (lupin grain) was fed for 6 days from 2 days after the second until the third PG injection. We measured reproductive and metabolic hormones, studied follicle dynamics (ultrasonography), and evaluated granulosa cell numbers, aromatase activity and oestradiol (E 2 ) concentrations in follicular fluid in healthy follicles at days 3 and 7 of supplementation. Ovulation rate was increased by 25% by exposure to high pre-/post-natal nutrition (1.5 vs 1.2; P!0.05), in association with a small decrease in FSH concentrations (PZ0.06) and a small increase in insulin concentrations (PZ0.07). The number of healthy antral follicles was not affected. Acute supplementation increased the number of granulosa cells (3.7G0.2 vs 3.0G0.2 million; P!0.05) in the largest follicle, and the circulating concentrations of E 2 (4.6G0.3 vs 3.9G0.3 pmol/l; P!0.05) and glucose (3.4G0.03 vs 3.3G0.03 mmol/l; P!0.01). Both early life nutrition and acute supplementation appear to affect ovulation rate through changes in glucose-insulin homoeostasis that alter follicular responsiveness to FSH and therefore E 2 -FSH balance.

show abstract

Section: Nutrition and Follicle Development In Merino Ewesmentioning

confidence: 99%

Follicle development, endocrine profiles and ovulation rate in adult Merino ewes: effects of early nutrition (pre- and post-natal) and supplementation with lupin grain

et al. 2014

View full text Add to dashboard Cite

show abstract

“…These authors indicate that short intervals between the two PF2 alpha analogues for TAI are related with poor reproductive outcomes. The estrus synchronization protocol based on Cloprostenol proposed in this trial was a 12 days interval, on which a favorable response could be related to the recruited follicles from a wide range of size, mainly from the two last follicular waves (Baby and Bartlewski 2011) and a more adequate endocrine environment than in short application intervals (Fierro et al 2011). Apparently, no negative effects of Cloprostenol were presented, because the conception rates were similar in both treatments (P>0.05).…”

Section: Discussionmentioning

confidence: 82%

Short communication: Estrus synchronization using progestogens or cloprostenol in tropical hair sheep

Ramírez

Arroyo-Ledezma²,

Pérez

et al. 2014

Trop Anim Health Prod

View full text Add to dashboard Cite

The objective of the experiment was to compare the use of a PGF2α analogue (Cloprostenol) IM, with an intravaginal progestagen sponge, flurogestone acetate (FGA), and equine chorionic gonadotropin (eCG) IM application protocol. A total of 30 cyclical hair ewes (54.07 ± 0.5 kg live weight, body condition score 3.5 ± 0.5, and age 3 ± 1 years) were used. For the control group ewes (n = 15), intravaginal sponges (IS) impregnated with 20 mg of FGA were inserted for 12 days with 500 IU of eCG IM at sponges withdrawal. For the PG group ewes (Treatment group n = 15), two injections of Cloprostenol (75 mcg) were given 12 days apart. The presence of estrus was detected using two rams with 8 h interval beginning at the end of the treatment. Progesterone concentrations in blood were measured by solid phase radioimmunoassay. A student's t test was performed to analyze the duration of estrus and the interval between the ends of the treatment and the onset of estrus (ET-OE) presentation. Progesterone levels were compared with two-way ANOVA, with treatment, and day of menstrual cycle as fixed factors. Treatment costs ratio was calculated by dividing the total costs of FGA IS application between total costs of Cloprostenol application. Significant differences (P < 0.05) were found in the (ET-OE) interval and estrus duration. For the control group, estrus was presented at 30 + 8.2 h; in treatment group, at 44 h after the last application, duration of estrus was 54.9 + 8.34 h, and 41 + 1.83 h for the control and treatment group, pregnancy rates were 53.3 and 60.0 %, respectively. Significant differences (P < 0.001) were found from days 9 to 13 on Progesterone levels in both treatments. Treatment costs of Cloprostenol protocol were 2.63 cheaper than FGA including disposable material, biological products, and labor. It was concluded that Cloprostenol could be an effective tool in estrus synchronization in hair sheep in tropical areas.

show abstract

“…Protocols based on PGF 2α result in good estrus and ovulation synchronization; however fertility was poor (Menchaca et al, 2004, Quintero-Elisea et al, 2011. Fierro et al (2011) demonstrated that even double dose of PGF 2a 7 days apart created lower progesterone environment leading to low fertility. In the present study, estrus detection rate was about 81% and conception rate was 100% in PGF 2α group, which were similar to progesterone based groups.…”

Section: Discussionmentioning

confidence: 99%

Effect of different short term synchronization protocols on estrus and fertility in non-pregnant ewes during the breeding season

Dursun

2019

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

The aim of this study was to investigate the efficacy of different short term synchronization protocols on estrus and pregnancy rates in merino ewes that had not become pregnant after at least three matings during the breeding season. Three different protocols were used as follows: Group I: Ewes (n=30) were inserted intravaginal progesterone sponge (florogestan asetate; 30 mg) for 6 days plus PGF2α (125 μg, i.m.) at the time of sponge removal, Group II: Ewes (40) were treated same as in group 1 plus eCG (250 IU, i.m.) at time of sponge removal, and Group III: Ewes (n=38) were only injected with PGF2α at the same time with the ewes in the other two groups. Estrus was detected by rams (n=4), 24 hours after PGF2α and ewes detected in estrus were mated. Ten rams were used for mating. Pregnancy was diagnosed 60 days after mating by ultrasonography. Estrus, conception and pregnancy rates were: for Group I 100%, 73.3% and 73.3%, for Group II 92.5%, 89.2% and 82.5% and for Group III 81.6%, 100% and 81%. In Group III, pregnancy loss after pregnancy diagnosis was significantly higher (35.4%) compared with the other groups (Group I: 13.6% and Group II: 15%).

show abstract

Effects of prostaglandin administration on ovarian follicular dynamics, conception, prolificacy, and fecundity in sheep

Cited by 36 publications

References 50 publications

Follicle development, endocrine profiles and ovulation rate in adult Merino ewes: effects of early nutrition (pre- and post-natal) and supplementation with lupin grain

Follicle development, endocrine profiles and ovulation rate in adult Merino ewes: effects of early nutrition (pre- and post-natal) and supplementation with lupin grain

Short communication: Estrus synchronization using progestogens or cloprostenol in tropical hair sheep

Effect of different short term synchronization protocols on estrus and fertility in non-pregnant ewes during the breeding season

Contact Info

Product

Resources

About