Effects of propranolol on the pressor response to noxious stimuli in hypertensive patients

Nicotero, James A.; Beamer, Virginia; Moutsos, Spero E.; Shapiro, Alvin P.

doi:10.1016/0002-9149(68)90202-6

Cited by 41 publications

(8 citation statements)

References 33 publications

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“…Nicotero et al (1968) could not demonstrate any change in rise in arterial pressure in response to noxious stimuli with propranolol but resting arterial pressure was also unaffected by propranolol and this represents a fundamental difference from our study. Ulrych (1969) used the intravenous route for administration of oxprenolol and since it is known that intravenous 16-adrenoceptor blocking agents do not change resting arterial pressure comparisons with our findings cannot be made.…”

Section: Resultscontrasting

confidence: 98%

Standardized stress and hypertension: comparison of effect of propranolol and methyldopa.

Fg¹,

Melville²,

Jones³

et al. 1978

Brit J Clinical Pharma

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1 Using a standardized form of mental stress, 21 patients with idiopathic hypertension were investigated before and after treatment with placebo (n=8), propranolol (n=7) or methyldopa (n=6). 2 Blood pressure was satisfactorily controlled in the propranolol and methyldopa groups but only the propranolol group showed modification of the pressor response to stress testing. 3 These results suggest that propranolol may provide more uniform control of blood pressure than methyldopa in patients with essential hypertension.

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Section: Resultscontrasting

confidence: 98%

Standardized stress and hypertension: comparison of effect of propranolol and methyldopa.

Fg¹,

Melville²,

Jones³

et al. 1978

Brit J Clinical Pharma

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“…8, 12 of which the circulatory reaction is a consequence. The critical time relation between stimuli and circulatory events, as indicated by the continuous records, makes a neural more likely than a humoral (adrenal) adrenergic effect.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive action of propranolol in man: Lack of evidence for a neural depressive effect

Guazzi

Fiorentini

Polese

et al. 1976

Clin Pharma and Therapeutics

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The hypothesis that a neural depressive action is related to the antihypertensive effects of beta blockers has been evaluated in 14 essential hypertensive male patients through the circulatory response to noxious stimuli. The pressor reaction to mental arithmetic was primarily mediated by cardiac stimulation (beta receptors activation), that to cold by vasoconstriction (alpha receptors activation). Arithmetic and cold were tested to separate the effects of peripheral beta blackade from possible neural and other influences. After propanolol (320 mg per day for 3 wk): (1) The baseline pressure was reduced; (2) appearance, peak, and disappearance time of the circulatory reaction to either stimulus was not altered; (3) the pressor effect of arithmetic was decreased in an extent proportional to the reduced rise of cardiac output; and (4) pressure during cold reached the pretreatment levels through an augmented increase of vascular resistance. Our findings indicate that propranolol depresses only the circulatory reactions mediated through beta receptors activation and provide no evidence of effects other than beta blockade.

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“…1970b). There is some evidence that propranolol reduces the rise in blood pressure that occurs in coitus (Fox, 1970), however, it does not appear to reduce the rise in pressure to painful stimuli (Nicotero et at., 1968), or cold water (Guazzi et al, 1976).…”

Section: Action On Valsalva 'V Manoeuvre and Blood Pressure Response mentioning

confidence: 99%

<i>β</i>-Adrenoceptor-Blocking Agents in the Management of Hypertension

Prichard

1979

Cardiology

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Effects of propranolol on the pressor response to noxious stimuli in hypertensive patients

Cited by 41 publications

References 33 publications

Standardized stress and hypertension: comparison of effect of propranolol and methyldopa.

Standardized stress and hypertension: comparison of effect of propranolol and methyldopa.

Antihypertensive action of propranolol in man: Lack of evidence for a neural depressive effect

<i>β</i>-Adrenoceptor-Blocking Agents in the Management of Hypertension

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Effects of propranolol on the pressor response to noxious stimuli in hypertensive patients

Cited by 41 publications

References 33 publications

Standardized stress and hypertension: comparison of effect of propranolol and methyldopa.

Standardized stress and hypertension: comparison of effect of propranolol and methyldopa.

Antihypertensive action of propranolol in man: Lack of evidence for a neural depressive effect

<i>&beta;</i>-Adrenoceptor-Blocking Agents in the Management of Hypertension

Contact Info

Product

Resources

About

<i>β</i>-Adrenoceptor-Blocking Agents in the Management of Hypertension