Effects of proportions of carbohydrates and fats in diets on mucin concentration and bile composition in gallbladder of dogs

Abstract

The associations of diet compositions with mucin secretion in gallbladder have not been investigated in dogs. This study aimed to examine the effects of a low-carbohydrate diet (LC) and a low-fat diet (LF) on bile mucin concentration and composition of gallbladder bile in six clinically healthy beagle dogs. After feeding of both diets, the bile mucin concentration was significantly decreased. In addition, there were significant decreases in the concentrations of taurochenodeoxycholic acid in bile, which is considered to promote mucin secretion, after feeding of both diets. The present study suggested that the proportions of carbohydrate and fat in diet affect the composition of gallbladder bile in dogs.

Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis

“…Mucins, a family of large, complex, glycosylated proteins, are secreted by the biliary duct and gallbladder epithelium in the biliary system [ 10 ]. The core of mucins typically consists of two domains.…”

Quantitative bile acid profiling in healthy adult dogs and pups from serum, plasma, urine, and feces using LC-MS/MS

“…Additionally, Thakare et al (30) expanded the cross-species BA analysis up to eleven different species, also including beagle dogs. In most of these studies involving dogs, BA analysis was either presented individually across various matrices or as collective report combining several matrices, and most of these studies were performed only in mixed breeds or beagle dogs (17,(31)(32)(33)(34)(35)(36). However, the lack of BA profiling studies in different age groups, the low number of studies for healthy clinical patient collectives of very different dog breeds, and the poorly characterized dietary effects on the BA profile still limit our understanding of the physiological range in BA concentrations and abnormal values in disease conditions.…”