Effects of Propolis on Spatial Memory Induced by Lithium Pilocarpine in the Experimental Status Epilepticus Model in the Rats

Kaya, Gülşen; Emre, Memet Hanifi

doi:10.7176/jnsr/9-18-01

Cited by 1 publication

(1 citation statement)

References 13 publications

(25 reference statements)

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“…In the Parkinson's disease and epilepsy models, propolis reduced neuronal loss and improved the histopathology associated with these diseases [46,47,49,69,70]. In all of these disease models, propolis consistently reduced the expression of inflammatory markers, maintained the antioxidant status, and improved motor/cognitive scores of the animals [44,45,48,69].…”

Section: Discussionmentioning

confidence: 96%

Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence

Zulhendri¹,

Perera

Tandean

2021

Biomedicines

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Propolis has been used therapeutically for centuries. In recent years, research has demonstrated its efficacy as a potential raw material for pharmaceuticals and nutraceuticals. The aim of the present scoping review is to examine the latest experimental evidence regarding the potential use of propolis in protecting the brain and treating neurological disorders and injuries. A systematic scoping review methodology was implemented. Identification of the research themes and knowledge gap was performed. After applying the exclusion criteria, a total of 66 research publications were identified and retrieved from Scopus, Web of Science, Pubmed, and Google Scholar. Several key themes where propolis is potentially useful were subsequently identified, namely detoxification, neuroinflammation, ischemia/ischemia-reperfusion injury/traumatic brain injury, Alzheimer’s disease, Parkinson’s disease, and epilepsy models, depression, cytotoxicity, cognitive improvement, regenerative medicine, brain infection, and adverse effects. In conclusion, propolis is shown to have protective and therapeutic benefits in alleviating symptoms of brain and neurological disorders and injuries, demonstrated by various in vitro studies, animal models, and human clinical trials. Further clinical research into this area is needed.

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