Effects of propolis, caffeic acid phenethyl ester, and pollen on renal injury in hypertensive rat: An experimental and theoretical approach

Salmas, Ramin Ekhteiari; Gülhan, Mehmet Fuat; Durdağı, Serdar; Şahna, Engin; Abdullah, Huda Ismail; Selamoğlu, Zeliha

doi:10.1002/cbf.3277

Cited by 38 publications

(23 citation statements)

References 80 publications

(88 reference statements)

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“…Previous studies have shown that both of them are increased in the heart after MI [ 24 , 25 ] and that dysregulation of the expression of these proteins contributes to collagen remodeling and subsequent cardiac fibrosis following MI [ 26 ]. Propolis was accepted as a traditional medicine; proven to be beneficial to human health [ 27 ] and possess a wide range of biological and pharmacological activities, including antiatherosclerosis [ 28 ], antioxidative stress, and antihypertensive [ 29 ]. FP, the main bioactive compound of propolis [ 30 , 31 ], has been shown to exhibit several cellular activities.…”

Section: Discussionmentioning

confidence: 99%

Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1

Wang

Sui

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The flavonoid extract from propolis (FP) has been shown to protect against heart injury induced by isoproterenol. However, the effect of FP on cardiac fibrosis after myocardial infarction (MI) as well as the underlying mechanisms is not known. In the present study, we used biochemical and histological approaches to examine the effects of FP on MI-induced cardiac fibrosis and the related mechanisms in a rat MI model and in angiotensin II- (Ang II-) treated rat cardiac fibroblasts (CFs). In vivo, MI was generated by ligation of the left anterior descending coronary artery of rats, which remained for 4 weeks. Rats were randomly divided into the sham, MI, FP (12.5 mg/kg/d), and MI+FP groups. We found that FP treatment improved heart function, reduced cardiac fibrosis, and downregulated the expression of fibrosis-related factors including collagen I, collagen III, matrix metalloproteinase-2 (MMP-2), MMP-9, transforming growth factor-β1 (TGF-β1), and p-Smad2/3, which coincided with the upregulated expression of silent information regulator 1 (SIRT1) in the hearts of MI rats. Our in vitro experiments showed that FP inhibited the proliferation and migration of primary cultured rat CFs and downregulated the expression of the above-mentioned fibrosis-related factors in Ang II-stimulated CFs. In addition, FP can decrease ROS production induced by MI and Ang II in vivo and vitro. Notably, silencing SIRT1 counteracted the FP-induced effects on CFs treated with Ang II. We conclude that FP inhibits MI-induced cardiac fibrosis through SIRT1 activation and that FP represents a potential promising drug for the treatment of MI patients in the clinic.

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Section: Discussionmentioning

confidence: 99%

Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1

Wang

Sui

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…The antioxidant properties of propolis have also been suggested to be responsible for its ability to modulate cardiovascular disease markers. Salmas et al [ 52 ], for example, reported that oxidative alterations occurring in the kidney tissue of chronic hypertensive rats might be prevented via propolis, CAPE, as well as pollen administration. In the kidney tissue of N ω -nitro-L-arginine methyl ester- (L-NAME-) induced hypertensive rats, total antioxidant status (TAS) and paraoxonase (PON1, an important antioxidant preventing the oxidation of low-density lipoproteins) activity, were significantly decreased, whereas total oxidant status (TOS), asymmetric dimethylarginine (ADMA, an endogenous inhibitor of NO synthase), and nuclear factor kappa B (NF- κ B, regulated by intracellular redox state) were significantly increased.…”

Section: Propolis: “Bee Glue”mentioning

confidence: 99%

Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application

Kocot

Kiełczykowska

Luchowska-Kocot

et al. 2018

Oxidative Medicine and Cellular Longevity

352

358

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Honeybees products comprise of numerous substances, including propolis, bee pollen, and royal jelly, which have long been known for their medicinal and health-promoting properties. Their wide biological effects have been known and used since antiquity. Bee products are considered to be a potential source of natural antioxidants such as flavonoids, phenolic acids, or terpenoids. Nowadays, the still growing concern in natural substances capable of counteracting the effects of oxidative stress underlying the pathogenesis of numerous diseases, such as neurodegenerative disorders, cancer, diabetes, and atherosclerosis, as well as negative effects of different harmful factors and drugs, is being observed. Having regarded the importance of acquiring drugs from natural sources, this review is aimed at updating the current state of knowledge of antioxidant capacity of selected bee products, namely, propolis, bee pollen, and royal jelly, and of their potential antioxidant-related therapeutic applications. Moreover, the particular attention has been attributed to the understanding of the mechanisms underlying antioxidant properties of bee products. The influence of bee species, plant origin, geographic location, and seasonality as well as type of extraction solutions on the composition of bee products extracts were also discussed.

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“…CAPE is a molecule with antioxidant and cytoprotective properties and plays a role in immunomodulation, is obtained from propolis extracted from honey bees [ 16 , 17 ]. At first propolis was known as a traditional medicine [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…CAPE is obtained from propolis honey bee through extraction [ 16 ], the structure of CAPE contains catechol which is a powerful antioxidant [ 17 ]. Propolis has long been used for many years as traditional medicine [ 18 ].…”

Section: F2 Isops Are Extremely Stable Compoundsmentioning

confidence: 99%

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Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury

Nasution

Islam

Hatta

et al. 2020

Annals of Medicine and Surgery

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Introduction The central nervous system (CNS) is the most metabolically active organ characterized by high oxygen demand and relatively low anti-oxidative activity, which makes neurons and glia highly susceptible to damage by reactive oxygen and nitrogen byproducts as well as neurodegeneration. Free radicals are associated with secondary injuries that occur after a primary brain injury. Some of these free radical products include F2-Isoprostane (F2-IsoPs), malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE) and acrolein. Methods In this study we measured serum F2-IsoPs levels as markers of free radical activity in 10–12 week-old male Sprague-Dawley rats weighing 200–300 g, all rats (n = 10) subjected with a head injury according to the modified marmourou model, then divided into 2 groups, one group treated with CAPE (Caffeic Acid Phenethyl Ester) (n = 5) and the other not treated with CAPE (n = 5), serum levels in the two groups were compared starting from day-0 (before brain injury), day-4 and day-7. Results We found lower F2-IsoPs levels in the group that received the CAPE treatment compared to the group that did not receive the CAPE treatment. Conclusion CAPE is capable of significantly reducing oxidative stress in brain injury.

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Effects of propolis, caffeic acid phenethyl ester, and pollen on renal injury in hypertensive rat: An experimental and theoretical approach

Cited by 38 publications

References 80 publications

Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1

Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1

Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application

Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury

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