Effects of propofol on oesophageal sphincters: a study on young and elderly volunteers using high-resolution solid-state manometry

Leon, Alex de; Ahlstrand, Rebecca; Thörn, Sven‐Egron; Wattwil, Magnus

doi:10.1097/eja.0b013e3283413211

Cited by 20 publications

(17 citation statements)

References 21 publications

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“…Before catheter placement, the volunteers received an intravenous bolus of propolipid 0.3 mg/kg, so as to make the procedure less uncomfortable. This dose of propolipid has previously been shown to leave the LES pressure unaffected …”

Section: Methodsmentioning

confidence: 92%

Pressure measurement in the upper esophagus during cricoid pressure: A high‐resolution solid‐state manometry study

Pellrud

Ahlstrand

2018

Acta Anaesthesiol Scand

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This study using high-resolution solid-state manometry under clinically relevant conditions shows that 30 N cricoid pressure generates high pressure in the area of the UES, far exceeding the levels previously considered necessary to prevent regurgitation. Additional studies are needed to clarify the effectiveness of cricoid pressure in preventing passive regurgitation before it is rejected as a part of rapid sequence induction.

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Section: Methodsmentioning

confidence: 92%

Pressure measurement in the upper esophagus during cricoid pressure: A high‐resolution solid‐state manometry study

Pellrud

Ahlstrand

2018

Acta Anaesthesiol Scand

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“…In our study, almost all patients were older than forty; therefore, propofol itself would not be expected to affect the motility of the esophagus. 13 …”

Section: Discussionmentioning

confidence: 99%

Does Sedation Affect Examination of Esophagogastric Junction during Upper Endoscopy?

Lee

Kim

et al. 2015

Yonsei Med J

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PurposeDuring sedated esophagogastroduodenoscopy (EGD), patients may not be able to perform inspiration, which is necessary to examine the esophagogastric junction. Therefore sedation may affect diagnosis of gastroesophageal reflux-related findings. The aim of our study was to investigate the effect of sedation on diagnosis of gastroesophageal reflux-related findings during EGD.Materials and MethodsThis retrospective study evaluated 28914 patients older than 20 years who underwent EGD at our institution between January 2011 and December 2011. Ultimately, 1546 patients indicated for EGD for health check-up and symptom evaluation were included.ResultsThere were 18546 patients who had diagnostic EGD: 10471 patients (56%) by non-sedated EGD and 8075 patients (43%) by sedated EGD. After statistical adjustment for age, sex, and body mass index, minimal change esophagitis, and hiatal hernia were significantly less frequently observed in the sedated EGD group [odds ratio (OR), 0.651; 95% confidence interval (CI), 0.586 to 0.722 and OR, 0.699; 95% CI, 0.564 to 0.866]. Nevertheless, there was no significant difference in other findings at the gastroesophageal junction, such as reflux esophagitis with Los Angeles classification A, B, C, and D or Barrett's esophagus, between the two groups. Similarly, there were no differences in early gastric cancer, advanced gastric cancer, and gastric ulcer occurrence.ConclusionSedation can impede the detection of minimal change esophagitis and hiatal hernia, but does not influence detection of reflux esophagitis of definite severity and Barrett's esophagus.

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“…23 Propofol at a small dose (0.3 mg/kg) does not have an effect on LES pressure, while higher doses produced a pressure increase. [22][23][24][25] However, propofol reduces UES pressures. 25 New agents like dexemedetomidine may reduce LES pressures.…”

Section: Esophageal Manometrymentioning

confidence: 99%

“…[22][23][24][25] However, propofol reduces UES pressures. 25 New agents like dexemedetomidine may reduce LES pressures. 22 Other anesthetics, opioids, and sedatives may have variable effects on sphincter and esophageal body motility 26 so interpretation of an abnormal study in patients who received these medications should be made with caution.…”

Section: Esophageal Manometrymentioning

confidence: 99%

An ANMS‐NASPGHAN consensus document on esophageal and antroduodenal manometry in children

Rosen

Garza

Tipnis

et al. 2017

Neurogastroenterology Motil

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This review highlights some of the recent advances in pediatric esophageal and antroduodenal motility testing including indications, preparation, performance, and interpretation of the tests. This update is the second part of a two part series on manometry studies in children (first part was on anorectal and colonic manometry [Neurogastroenterol Motil. 2016;29:e12944]), and has been endorsed by the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) and the American Neurogastroenterology and Motility Society (ANMS).

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Effects of propofol on oesophageal sphincters: a study on young and elderly volunteers using high-resolution solid-state manometry

Cited by 20 publications

References 21 publications

Pressure measurement in the upper esophagus during cricoid pressure: A high‐resolution solid‐state manometry study

Pressure measurement in the upper esophagus during cricoid pressure: A high‐resolution solid‐state manometry study

Does Sedation Affect Examination of Esophagogastric Junction during Upper Endoscopy?

An ANMS‐NASPGHAN consensus document on esophageal and antroduodenal manometry in children

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