Effects of Propofol Combined with Sufentanil Target-Controlled Intravenous Anesthesia on Expression of Bax, Bcl-2, and Caspase-3 Genes in Spontaneous Hypertensive Rats with Cerebral Hemorrhage: a Prospective Case-Controlled Study

Li, Lei; Xu, Qiao; Ye, Siqi; Ke, Yan

doi:10.1007/s12010-023-04378-0

Appl Biochem Biotechnol

2023

DOI: 10.1007/s12010-023-04378-0

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Effects of Propofol Combined with Sufentanil Target-Controlled Intravenous Anesthesia on Expression of Bax, Bcl-2, and Caspase-3 Genes in Spontaneous Hypertensive Rats with Cerebral Hemorrhage: a Prospective Case-Controlled Study

Lei Li

Qiao Xu

Siqi Ye

et al.

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Measurement of blood pressure in rats: Invasive or noninvasive methods?

Kapsdorferová,

Grešová,

Švorc

2024

Physiological Reports

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Experiments should always be based on control values. This assumption fully applies to cardiovascular parameters, such as heart rate (HR) and blood pressure (BP), which are highly sensitive to various external and internal stimuli and can already be significantly altered when an experiment begins. Therefore, it is necessary to determine which values are defined as a starting point (i.e., control and baseline) or compare them with valid reference values if the goal is to evaluate the changes after experimental intervention. A generally accepted principle is a reciprocal relationship between BP and HR, in which one parameter affects the other and vice versa. BP can be measured using two methods—noninvasively (tail‐cuff) and invasively (telemetry, direct measurements of BP after introducing the sensor directly into the artery), and HR directly or by extrapolation from BP recordings. This study does not aim to evaluate the results of individual studies, but to review whether there are differences in control (baseline) BP values in normotensive and hypertensive male rats using invasive versus noninvasive methods, and to investigate whether there is a causal relationship between BP and HR in in vivo experiments with male rats.

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Measurement of blood pressure in rats: Invasive or noninvasive methods?

Kapsdorferová,

Grešová,

Švorc

2024

Physiological Reports

View full text Add to dashboard Cite

show abstract

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Effects of Propofol Combined with Sufentanil Target-Controlled Intravenous Anesthesia on Expression of Bax, Bcl-2, and Caspase-3 Genes in Spontaneous Hypertensive Rats with Cerebral Hemorrhage: a Prospective Case-Controlled Study

Cited by 1 publication

References 16 publications

Measurement of blood pressure in rats: Invasive or noninvasive methods?

Measurement of blood pressure in rats: Invasive or noninvasive methods?

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