Effects of propofol and sevoflurane on isolated human umbilical arteries pre‐contracted with dopamine, adrenaline and noradrenaline

Background: Naturally occurring bioactive compounds have a plethora of biological effects. Objective: In this study, we examined a pharmacological screening of natural products on the human umbilical artery (HUA). Methods: HUA preparations were used to follow contractions by KCl (60 mM) and tested at different concentrations (1-5000 μg/mL and μM) of the Lippia alba (EOLa) and Lippia origanoides (EOLo) essential oils, terpenes (citral, limonene perilic alcohol) and phenylpropanoids (eugenol, methyl eugenol). Discussion/Results: The reduction corresponded to approximately 100%, except for limonene (80±1.2 %). When evaluating the concentration of the natural product that promotes 50 % relaxation of the HUA contracted by KCL, EC50 values were: 424.3 μg/mL (EOLa); 468.7±6.7 μg/mL (EOLo); 264.2 ± 8.2 μM (citral); 677.8±5.4 μM (limonene); 186.3±6.4 μM (peryl alcohol); 986.4±7.9 μM (eugenol); and 279.1±4.4 μM (methyl-eugenol). Perillyl alcohol had a lower EC50 (consequently it has a higher pharmacological potency). Conclusion: The plant extracts have a promising vasorelaxing effect in HUAs, paving the way for future investigations: as applications in diseases related to these vessels, such as preeclampsia.

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Effects of propofol and sevoflurane on isolated human umbilical arteries pre‐contracted with dopamine, adrenaline and noradrenaline

Cited by 2 publications

References 40 publications

Propofol: farmacodinámica y uso práctico

Propofol: farmacodinámica y uso práctico

Pharmacological Screening of Species from the Lippia genus, Content in Terpenes and Phenylpropanoids, and their Vasorelaxing Effects on Human Umbilical Artery

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