Effects of propofol, alfaxalone and isoflurane on cerebral blood flow and cerebrovascular reactivity to CO2 in dogs

Bini, G; Bailey, Kate; Voyvodic, James T.; Chiavaccini, Ludovica; Muñana, Karen R.; Keenihan, Erin K

doi:10.1016/j.vaa.2020.07.007

Cited by 3 publications

(3 citation statements)

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“…Cerebral blood flow was significantly lower with alfaxalone (3.5 mg/kg followed by 0.15 mg/kg/minute) or propofol anaesthesia (7 mg/kg followed by 0.4 mg/kg/minute) compared with isoflurane anaesthesia (end-expiratory fraction 1.7%) in nonpremedicated dogs. However, alfaxalone maintained higher hypocapnic cerebrovascular reactivity to carbon dioxide (Bini et al 2020).…”

Section: Cardiovascular Effects Of Alfaxalonementioning

confidence: 85%

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Clinical review of the pharmacological and anaesthetic effects of alfaxalone in dogs

Bellido¹,

Vettorato²

2021

J of Small Animal Practice

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This clinical review summarises the pharmacological and anaesthetic properties of alfaxalone in the dog. Available pharmacokinetic‐pharmacodynamic data and factors affecting the induction dose have been reported. Furthermore, quality of induction and recovery after alfaxalone administration, the use of alfaxalone for total intravenous anaesthesia, and its effects on the cardio‐respiratory system, on laryngeal motion, on intraocular pressure and tear production have been evaluated. Finally, the use of alfaxalone in dogs undergoing caesarean section and the effect of intramuscular alfaxalone administration have been considered.

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Section: Cardiovascular Effects Of Alfaxalonementioning

confidence: 85%

“…However, alfaxalone maintained higher hypocapnic cerebrovascular reactivity to carbon dioxide (Bini et al . 2020).…”

Section: Cardiovascular Effects Of Alfaxalonementioning

confidence: 99%

Clinical review of the pharmacological and anaesthetic effects of alfaxalone in dogs

Bellido¹,

Vettorato²

2021

J of Small Animal Practice

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“…The combined use of alfaxalone and alfadolone decreased CBF substantially in cats measured by 133Xe [ 162 ]. Moreover, a recent report showed that alfaxalone resulted in significantly lower CBF in dogs in comparison with isoflurane [ 163 ]. Neural activity in the brain is usually coupled with local CBF increase, the basis of a BOLD signal generated in the vasculature [ 164 ].…”

Section: Effects Of Anesthesia On Cbf and Functional Connectivity Of ...mentioning

confidence: 99%

Effects of Anesthesia on Cerebral Blood Flow and Functional Connectivity of Nonhuman Primates

Zhang

2022

Veterinary Sciences

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Nonhuman primates (NHPs) are the closest living relatives of humans and play a critical and unique role in neuroscience research and pharmaceutical development. General anesthesia is usually required in neuroimaging studies of NHPs to keep the animal from stress and motion. However, the adverse effects of anesthesia on cerebral physiology and neural activity are pronounced and can compromise the data collection and interpretation. Functional connectivity is frequently examined using resting-state functional MRI (rsfMRI) to assess the functional abnormality in the animal brain under anesthesia. The fMRI signal can be dramatically suppressed by most anesthetics in a dose-dependent manner. In addition, rsfMRI studies may be further compromised by inter-subject variations when the sample size is small (as seen in most neuroscience studies of NHPs). Therefore, proper use of anesthesia is strongly demanded to ensure steady and consistent physiology maintained during rsfMRI data collection of each subject. The aim of this review is to summarize typical anesthesia used in rsfMRI scans of NHPs and the effects of anesthetics on cerebral physiology and functional connectivity. Moreover, the protocols with optimal rsfMRI data acquisition and anesthesia procedures for functional connectivity study of macaque monkeys are introduced.

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Anaesthesia for head trauma patients

Bell

2021

The Veterinary Nurse

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There are many reasons anaesthetising a patient with head trauma may be required. These include for diagnostic imaging, surgery, or it may be required in severe cases to control the patient's ventilation. Many anaesthetic agents cause changes to the blood flow to the brain and therefore may cause further detriment to the patient. Thus, the veterinary nurse assisting the veterinary surgeon with these cases requires a thorough understanding of the physiology of head trauma and the effects of anaesthetic agents on cerebral blood flow, intracranial pressure and the cardiac and respiratory systems, as well as possible neuroprotective benefits that can be gained from the use of some agents.

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Effects of propofol, alfaxalone and isoflurane on cerebral blood flow and cerebrovascular reactivity to CO2 in dogs

Cited by 3 publications

References 0 publications

Clinical review of the pharmacological and anaesthetic effects of alfaxalone in dogs

Clinical review of the pharmacological and anaesthetic effects of alfaxalone in dogs

Effects of Anesthesia on Cerebral Blood Flow and Functional Connectivity of Nonhuman Primates

Anaesthesia for head trauma patients

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