Effects of prolonged exposure of mouse embryos to elevated temperatures on embryonic developmental competence

Choi, Inchul; Amarnath, Dasari; Kim, Nam‐Hyung; Campbell, Keith

doi:10.1016/j.rbmo.2015.04.017

Cited by 15 publications

(4 citation statements)

References 72 publications

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“…More recently, research has begun to focus on the impact that environmental factors may have on PTD. Animal models support the biological plausibility of a relationship between extreme heat and adverse pregnancy outcomes including early gestational birth [ 18 – 22 ]. These previous studies give biologic plausibility to the hypothesis that apparent temperature may be a contributing factor for the risk of PTD.…”

Section: Introductionmentioning

confidence: 99%

The impact of high apparent temperature on spontaneous preterm delivery: a case-crossover study

Avalos

Chen

et al. 2017

Environ Health

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BackgroundDespite the prediction that temperatures are expected to increase in the future, little is known about the health effects of increasing temperatures on pregnant women. The objective of this study was to investigate the impact of apparent temperature on spontaneous preterm delivery (PTD).MethodsA case-crossover study of 14,466 singleton spontaneous preterm deliveries occurring between January 1, 1995 and December 31, 2009 among Kaiser Permanente Northern California (KPNC) members was conducted. Preterm deliveries were identified through KPNC's Electronic Health Records (EHR) data. Data on gestational age at delivery, infant sex, and maternal address were also extracted from KPNC's EHR and linked to meteorologic and air pollution monitoring data based on residential zip code.ResultsAn 11.6% (95% CI: 4.1, 19.7) increase in spontaneous PTD was associated with a 10 °F (5.6 °C) increase in weekly average (lag06) apparent temperature, during the warm season. During the cold season, increases in apparent temperature did not significantly impact the overall effect of spontaneous PTD (6.2%, (95% CI: -3.0, 16.2) per 10 °F (5.6 °C) increase in weekly average (lag06) apparent temperature). Significant differences in the relationship between apparent temperature and spontaneous PTD emerged for region, gestational age and infant sex, during the cold season. No significant differences emerged for air pollutants.ConclusionsOur findings provide evidence for an increase in the odds of spontaneous PTD associated with increases in apparent temperature, especially during the warm season.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0209-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

The impact of high apparent temperature on spontaneous preterm delivery: a case-crossover study

Avalos

Chen

et al. 2017

Environ Health

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“…Susceptibility of the early preimplantation embryo to elevated temperatures has been well characterized in cattle (Edwards & Hansen, ; Paula‐Lopes, Chase et al, ; Sakatani, Kobayashi, & Takahashi, ), sheep (Alliston & Ulberg, ), mice (Aréchiga & Hansen, ; Aréchiga, Ealy, & Hansen, ; Choi, Dasari, Kim, & Campbell, ; Koyama, Ikeda, Sugimoto, & Kume, ; Ozawa, Hirabayashi, & Kanai, ), and rabbits (Alliston, HOWARTH, & Ulberg, ; Makarevich et al, ). In cattle, exposure of Holstein heifers to heat stress during the first 7 days after estrus increased the proportion of abnormal and slow developing embryos (Putney, Mullins, Thatcher, Drost, & Gross, ).…”

Section: Effect Of Heat Stress On Embryonic Developmentmentioning

confidence: 99%

Cellular and epigenetic changes induced by heat stress in bovine preimplantation embryos

Barros

Paula-Lopes

2018

Molecular Reproduction Devel

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Exposure of the preimplantation embryo to heat stress triggers a series of cellular, molecular, and adaptive changes preventing a normal embryonic development. Heat stress disrupts the embryo cytoskeleton, intracellular calcium levels, mitochondrial function, and induces apoptosis. Moreover, heat stress can act indirectly through induction of reactive oxygen species (ROS), leading to a variety of cellular damage. Embryonic resistance to heat shock is determined by factors such as genotype, developmental stage, apoptosis, redox status, and regulatory molecules. The early embryo is very susceptible to heat stress; it acquires resistance to elevated temperature as development advances. One of the mechanisms involved in the developmental acquisition of thermotolerance is heat-induced apoptosis, which acts as a quality control mechanism to remove damaged blastomeres allowing the embryo to survive after stress. Although embryos at >8-cell stage can activate the apoptotic cascade as an adaptive response to stress, embryos at the two-cell stage are resistant to proapoptotic signals. This lack of apoptotic response has been associated to mitochondrial resistance to depolarization and epigenetic regulations, such as DNA methylation and histone deacetylation. Even though the cellular mechanisms triggered by heat stress have been studied, very little attention has been paid to the vulnerability of the epigenome to drastic temperature changes during the preimplantation period. Therefore, this review aims to characterize the effects of elevated temperature on the bovine embryo, especially addresissing developmental, cellular, and epigenetic alterations triggered in response to temperature.

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“…4,8,9 Furthermore, animal models support the biological plausibility of a detrimental relationship between extreme temperature and health at birth. 10,11 The available literature mostly consists of association studies on temperature and birth outcomes.…”

Section: Introductionmentioning

confidence: 99%

The impact of extreme temperatures on birth outcomes in the Netherlands: a nationwide population-based study

Burgos Ochoa,

Garcia-Gomez,

Steegers

et al. 2023

Preprint

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BackgroundClimate projections predict an increased frequency and intensity of extreme weather events, such as extreme temperatures, prompting concerns about their impact on early-life health and health disparities. This study aimed to investigate the causal impact of in-utero exposure to extreme temperatures on birth outcomes and effect heterogeneity across levels of socioeconomic status (SES).MethodsWe obtained data on singleton births that occurred between 2003 and 2017 from the Dutch perinatal registry (N=2 472 352). Exposure was calculated as the number of days during the gestational period in which the mean temperature fell into each of mutually exclusive bins, with the 8–12 °C bin used as reference. To identify a causal effect, we exploited the unpredictability of daily temperature fluctuations while accounting for seasonal and underlying trends. Effect heterogeneity was assessed across levels of household income, neighbourhood SES, and maternal education.ResultsIn-utero exposure to an additional hot day (mean temperature > 20 °C), relative to the reference range, led to increased odds of low birth weight (LBW) (OR[95%CI]= 1.007 [1.005, 1.009]), small for gestational age (SGA) (OR[95%CI]= 1.004 [1.003, 1.005]), and preterm birth (PTB) (OR[95%CI]= 1.006 [1.005, 1.007]). Exposure during the second trimester to an additional cold day (< -4 °C) led to increased odds of LBW and PTB. The observed effects were the most detrimental for births in low-SES households.ConclusionsIn-utero exposure to extreme temperature has a detrimental impact on birth outcomes in the Netherlands. Projected increases in extreme temperatures may further exacerbate health disparities in early life.

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Effects of prolonged exposure of mouse embryos to elevated temperatures on embryonic developmental competence

Cited by 15 publications

References 72 publications

The impact of high apparent temperature on spontaneous preterm delivery: a case-crossover study

The impact of high apparent temperature on spontaneous preterm delivery: a case-crossover study

Cellular and epigenetic changes induced by heat stress in bovine preimplantation embryos

The impact of extreme temperatures on birth outcomes in the Netherlands: a nationwide population-based study

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