Effects of Prolonged Cortisone Therapy on the Statural Growth, Skeletal Maturation and Metabolic Status of Children

Blodgett, Frederick M.; Burgin, Leo B.; Iezzoni, Domenic G.; Gribetz, Donald; Talbot, Ńathan B.

doi:10.1056/nejm195604052541402

Cited by 354 publications

(127 citation statements)

References 1 publication

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“…This peripheral resistance to somatomedin may be partially related to steroid therapy, since three of the four patients with subnormal growth velocity (SC, PC, and RM) had the highest average steroid dosage levels (20.0, 9.1, and 12.5 mg/m2/24 hr, respectively). Growth retardation associated with high dosage steroid therapy has been well documented [2,23,29,341 and steroidal inhibitory effects upon rat rib cartilage have been demonstrated.The in vivo uptake of radioactive sulfate by rat cartilage was inhibited when the animal was treated with large doses of hydrocortisone [4, 351. Likewise, the conversion by rat rib cartilage of (14C)proline to hydroxyproline was inhibited by cortisol in vitro at a level of 0.9 pg/ml [7], a level which markedly exceeds physiologic concentrations.…”

Section: Col-elation Between G V B a And Other Variablesmentioning

confidence: 99%

Somatomedin and Growth after Renal Transplantation

et al. 1974

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Section: Col-elation Between G V B a And Other Variablesmentioning

confidence: 99%

Somatomedin and Growth after Renal Transplantation

et al. 1974

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“…Our study observed a decrease in height percentile in children treated with steroids. The negative effect of oral steroids on pediatric height velocity is well documented (7,8). This is assumed to be due to the greater susceptibility of an actively growing skeleton to the osteoblast-inhibiting effects of corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Propranolol therapy for infantile hemangioma is less toxic but longer in duration than corticosteroid therapy

Sawa¹,

Yazdani²,

Rieder³

et al. 2014

CAN J PLAST SURG

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“…41 Prednisone doses ≥ 0.16 mg/kg/day for children were considered to cause osteopenia (B). 42 Children with juvenile idiopathic arthritis on 0.62 mg/ kg/day of prednisone showed an increased risk of vertebral fracture in 2.6 years (B). 43 That study supports the recommendation that, when children and adolescents are already on GC, densitometry should be ordered due to the risk of fracture (D).…”

Section: Should Densitometry Be Performed In Children and Adolescentsmentioning

confidence: 99%

“…Densitometry should be performed in children and adolescents who will initiate GC therapy (prevention) at prednisone doses ≥ 0.16 mg/kg/day, because those doses are considered to cause osteopenia (B), 42 and in those who have already undergone four or more courses of systemic GC (A). 41 Based on the recommendations for adults, densitometry should be performed in children and adolescents on GC therapy (treatment), before GC use and as a control, assessing lumbar spine and whole body (excluding the head).…”

Section: Recommendationmentioning

confidence: 99%

Diretrizes para prevenção e tratamento da osteoporose induzida por glicocorticoide

Pereira¹,

Carvalho²,

Paula³

et al. 2012

Rev. Bras. Reumatol.

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Glucocorticoids (GC) are used in almost all medical specialties, and approximately 0.5% of the general population of the United Kingdom receives those medications. With the increased survival of patients with rheumatological diseases, morbidity secondary to the use of those medications represents an important aspect of the management of our patients. The incidences of vertebral and non-vertebral fractures are elevated, ranging from 30% to 50% of the individuals on GC for over three months. Thus, osteoporosis and frailty fractures should be prevented and treated in all patients initiating or already on GC. There are several recommendations on this topic elaborated by several international societies, but consensus still lacks. Recently, the American College of Rheumatology has published new recommendations, but they are based on the WHO Fracture Risk Assessment Tool (FRAX®) to evaluate the risk for each individual, and, thus, cannot be completely used for the Brazilian population. Thus, the Committee for Osteoporosis and Bone Metabolic Disorders of the Brazilian Society of Rheumatology, along with the Brazilian Medical Association and the Brazilian Association of Physical Medicine and Rehabilitation, has elaborated the Brazilian Guidelines for Glucocorticoid-Induced Osteoporosis (GIO), based on the better available scientifi c evidence and/or expert experience. Method of evidence collection: The bibliographic review of scientifi c articles of this guideline was performed in the MEDLINE database. The search for evidence was based on real clinical scenarios, and used the following keywords (MeSH Osteoporosis/prevention & control, Calcium, Vitamin D, Vitamin D defi ciency, Calcitriol, Receptors, Calcitriol; Hydroxycholecalciferols, Prevention and Control, Spinal fractures/prevention & control, Fractures, Spontaneous, Lumbar Vertebrae/injuries, Lifestyle, Alcohol Drinking, Smoking OR tobacco use disorder, Movement, Resistance Training, Exercise Therapy, Bone density OR Bone and Bones, Densitometry, Radiography, (Diphosphonates Alendronate OR Risedronate Pamidronate OR propanolamines OR Ibandronate OR Zoledronic acid, Men AND premenopause, pregnancy, pregnancy outcome maternal, fetus, lactation, teratogens,, adolescence (13-18 years). Grade of recommendation and level of evidence: A) Data derived from more consistent experimental and observational studies; B) Data derived from less consistent experimental and observational studies; C) Case reports (uncontrolled studies); D) Expert opinion without explicit critical appraisal, or based on consensus, physiological studies or animal models. Objective: To establish guidelines for the prevention and treatment of GIO.

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Effects of Prolonged Cortisone Therapy on the Statural Growth, Skeletal Maturation and Metabolic Status of Children

Cited by 354 publications

References 1 publication

Somatomedin and Growth after Renal Transplantation

Somatomedin and Growth after Renal Transplantation

Propranolol therapy for infantile hemangioma is less toxic but longer in duration than corticosteroid therapy

Diretrizes para prevenção e tratamento da osteoporose induzida por glicocorticoide

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