Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30)

Mavoungou, Elie; Bouyou-Akotet, Marielle Karine; Kremsner, Peter G.

doi:10.1111/j.1365-2249.2004.02686.x

Cited by 72 publications

(55 citation statements)

References 49 publications

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“…The activity of NK cells is also known to be changed by acute psychological stress (42) and to be reduced by an increase in cortisol levels (43). In the present study, NK cell activity was maintained at a relatively high level during the preexamination period but was reduced immediately after the examination in the two groups.…”

Section: Discussionsupporting

confidence: 52%

Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress

Kato-Kataoka

Nishida

Takada

et al. 2016

Appl Environ Microbiol

213

174

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Stress-induced abdominal dysfunction is an attractive target for probiotics. To investigate the effects of the probiotic Lactobacillus casei strain Shirota on abdominal dysfunction, a double-blind, placebo-controlled trial was conducted with healthy medical students undertaking an authorized nationwide examination for academic advancement. For 8 weeks, until the day before the examination, 23 and 24 subjects consumed an L. casei strain Shirota-fermented milk and a placebo milk daily, respectively. In addition to assessments of abdominal symptoms, psychophysical state, and salivary stress markers, gene expression changes in peripheral blood leukocytes and composition of the gut microbiota were analyzed using DNA microarray analysis and 16S rRNA gene amplicon sequence analysis, respectively, before and after the intervention. Stress-induced increases in a visual analog scale measuring feelings of stress, the total score of abdominal dysfunction, and the number of genes with changes in expression of more than 2-fold in leukocytes were significantly suppressed in the L. casei strain Shirota group compared with those in the placebo group. A significant increase in salivary cortisol levels before the examination was observed only in the placebo group. The administration of L. casei strain Shirota, but not placebo, significantly reduced gastrointestinal symptoms. Moreover, 16S rRNA gene amplicon sequencing demonstrated that the L. casei strain Shirota group had significantly higher numbers of species, a marker of the alpha-diversity index, in their gut microbiota and a significantly lower percentage of Bacteroidaceae than the placebo group. Our findings indicate that the daily consumption of probiotics, such as L. casei strain Shirota, preserves the diversity of the gut microbiota and may relieve stress-associated responses of abdominal dysfunction in healthy subjects exposed to stressful situations. IMPORTANCEA novel clinical trial was conducted with healthy medical students under examination stress conditions. It was demonstrated that the daily consumption of lactic acid bacteria provided health benefits to prevent the onset of stress-associated abdominal symptoms and a good change of gut microbiota in healthy medical students. The gut microbiota, a large, diverse, and dynamic ecosystem that generates cross talk between the gut and host, can communicate with the host by modulating the gut-brain axis, which is a bidirectional neurohumoral communication system between the gut and brain. That is, signals from the brain modify the motor, sensory, and secretory modalities of the gastrointestinal tract; in turn, signals from the gut can affect emotional behavior and stress and pain modulation systems through neural, endocrine, and immune pathways (1-3). Thus, the gut-brain axis has now been expanded to the microbiota-gut-brain axis (3).It is particularly interesting to consider the possibility that probiotics (4), which are live microorganisms, can affect emotion in health and disease by modulating the microbiota-g...

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Section: Discussionsupporting

confidence: 52%

Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress

Kato-Kataoka

Nishida

Takada

et al. 2016

Appl Environ Microbiol

213

174

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“…In contrast, cortisol downregulates the expression of NKp30. 86 Our data are interesting because NKp30 acts together with NKp46 to induce cytotoxic activity against a variety of target cells. These results have important implications for the understanding of the involvement of NK cells in the susceptibility of pregnant women to P. falciparum malaria.…”

Section: Cortisol Prolactin and Susceptibility Of Pregnant Women To mentioning

confidence: 98%

“…Nevertheless, we and others have demonstrated that the surface expression and function of the triggering receptors responsible for NK-mediated recognition and killing of tumor cells is regulated by hormones. 85,86 Prolactin selectively upregulates the surface expression of NKp46 and NKp30. In contrast, cortisol downregulates the expression of NKp30.…”

Section: Cortisol Prolactin and Susceptibility Of Pregnant Women To mentioning

confidence: 99%

Interactions Between Natural Killer Cells, Cortisol and Prolactin in Malaria During Pregnancy

Mavoungou¹

2006

Clinical Medicine & Research

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Natural killer cells derived from pluripotent hematopoietic stem cells are important cells of the immune system that have two main functions: a cytolytic activity and a cytokine-producing capacity. These functions are tightly regulated by numerous activating and inhibitory receptors, including newly discovered receptors that selectively trigger the cytolytic activity in a major histocompatibility complex independent manner. Based on their defining function of spontaneous cytotoxicity without prior immunization, natural killer (NK) cells have been thought to play a critical role in immune surveillance and cancer therapy. New insights into NK cell biology have suggested their major roles in the control of infections, particularly in Plasmodium falciparum infection and in fetal implantation. P. falciparum is the main protozoan parasite responsible for malaria causing 200-300 million clinical cases and killing over 3 million people each year. This review provides an update on NK cell function, ontogeny and biology in order to better understand the role of NK cells in pregnancy in regions where malaria is endemic. Understanding mechanisms of NK cell functions may lead to novel therapeutic strategies for the treatment of human disease, in general, and particularly in the fight against malaria.

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“…The killing of K562 cells by fresh human NK cells is mediated mainly by the NKp46 receptor (59,70,71). To define the specificity of the effect of HA on NK cell activity, we further examined the redirected cytotoxicity of NK cells, which is induced by the monoclonal antibody against a specific receptor and therefore reflects the specific receptormediated cytotoxicity.…”

Section: Influenza Virus Ha Binds Nk Cells Through Sialic Acidmentioning

confidence: 99%

Inhibition of Human Natural Killer Cell Activity by Influenza Virions and Hemagglutinin

Mao

Liu

et al. 2010

J Virol

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Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30)

Cited by 72 publications

References 49 publications

Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress

Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress

Interactions Between Natural Killer Cells, Cortisol and Prolactin in Malaria During Pregnancy

Inhibition of Human Natural Killer Cell Activity by Influenza Virions and Hemagglutinin

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