Effects of progressive myocardial ischaemia on systolic function, diastolic dysfunction, and load dependent relaxation

Abstract

(1) Changes in systolic and diastolic function occurred concomitantly as mild regional myocardial ischaemia developed and intensified; (2) afterloading significantly worsened regional systolic and diastolic dysfunction during mild ischaemia; and (3) progression of regional ischaemia resulted in loss of load dependent relaxation.

Defining the Transmurality of a Chronic Myocardial Infarction by Ultrasonic Strain-Rate Imaging

“…The presence of "ischemiarelated" postsystolic thickening after 5 weeks of chronic ischemia would again suggest that this may be a marker of segmental viability. 15,16 It also emphasizes the importance of the precise timing of regional deformation when analyzing function in complex ischemic substrates.…”

Investigating Cardiac Function Using Motion and Deformation Analysis in the Setting of Coronary Artery Disease

“…7 (left) demonstrates the influence of afterload on systolic deformation, systolic bulging, and PST at baseline during different degrees of ischemia and reperfusion. 19 The deformation is shown under normal loading condition and with an acute increase in afterload. With increasing preload, both PST and systolic bulging are reduced (Figure 3, right).…”

“…B, Changes with preload in ischemic PST and systolic bulging. A is reprinted from Leone et al, 19 with permission from The European Society of Cardiology. B is reprinted from Dalmas et al, 21 with permission from Cambridge University Press.…”

Strain-Rate Imaging During Dobutamine Stress Echocardiography Provides Objective Evidence of Inducible Ischemia

“…4 -6 In animal and human studies, myocardial ischemia also caused a delayed onset and termination of systolic shortening. [7][8][9][10] However, it is difficult to visually assess this potential sign of ischemia during DSE. 11 Echocardiographic strain-rate imaging (SRI) 12 reliably measures regional myocardial deformation (strain, ⑀) and deformation rate (strain rate, SR) compared with sonomicrometry.…”