Effects of progesterone withdrawal on uterine prostaglandin levels in the ovariectomized pregnant rat

Wilson, Laird; Lindsey, Russell

doi:10.1016/0262-1746(87)90101-6

Cited by 9 publications

(1 citation statement)

References 29 publications

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“…Csapo & Wiest (1969) also demonstrated hypertrophy of the placenta in ovariectomized rats. Wilson & Lindsey (1987) have shown that progesterone withdrawal is a potent stimulus for uterine prostaglandin synthesis. Prostaglandins are the known cause of tissue inflammation and a cause of increasing capillary permeability (Moneada et ai, 1980).…”

Section: Discussionmentioning

confidence: 99%

Critical progesterone requirement for maintenance of pregnancy in ovariectomized rats

Arkaravichien

Kendle²

1990

Reproduction

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The minimum progesterone concentration required to maintain the pregnancy was studied by varying doses of progesterone given subcutaneously to rats ovariectomized on Day 8 of pregnancy. Injecting 3 mg progesterone plus 200 ng oestradiol benzoate daily provided serum progesterone values between 25.4 +/- 7.0 and 35.2 +/- 6.2 ng/ml throughout Days 10-19 which were significantly lower than normal levels (P less than 0.05), but resulted in 93.6% of fetal survival on Day 19 which was not significantly different from 93.3% in the control group. Injecting 2 mg progesterone plus 200 ng oestradiol benzoate daily gave progesterone values between 13.2 +/- 4.6 and 19.0 +/- 6.2 ng/ml and could not maintain fetal viability to Day 19 (14.2%, P less than 0.05 compared with control group). Critical times to supplement progesterone in rats ovariectomized on Day 8 or Day 15 were studied by varying the time of progesterone implantation after ovariectomy. Progesterone implants were administered 8, 12 and 24 h after ovariectomy on Day 8 and 24, 36 and 48 h after ovariectomy on Day 15. On Day 8, progesterone replacement could be delayed to 8 h but not 12 h, while on Day 15, progesterone replacement could be delayed up to 36 h but not 48 h after ovariectomy without affecting fetal survival.

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Section: Discussionmentioning

confidence: 99%