Effects of Progesterone Receptor Modulators (PRMs) on the ectopic endometrium of uterus and ovaries

Abstract

Endometrial thickness >20 mm (N, %) 15 (29.4%) 1 (33.3%) ns Myometrial nodule (N, %) 37 (71.2%) 3 (100%) ns Nodule vascularization at Color Doppler (N, %) 27 (90%) 2 (66.6%) ns Nodule maximum diameter (average AE SD) 34.5 AE 21.1 mm 29.3 AE 10.0 mm ns UAPI (average AE SD) Mean right/left UAPI 1.67 AE 0.94 3.25 AE 0.81 0.01Results: Forty patients with post-molar GTN (74%), 11 patients with nonmolar GTN (20.4%) and 3 patients with PSTT (5.6%) were included in the analysis. None of the ultrasonographic features evaluated (presence of endometrial disease; presence of a myometrial lesion; lesion morphology, diameter and vascularization) significantly differed between PSTT and other types of GTN. However, a significant difference could be detected between UAPI measurements in GTN and PSTT (P = 0.01). Conclusions: Our results show that patients suffering from PSTT present higher resistance of uterine arteries, compared to invasive mole and choriocarcinoma. PSTT pattern is similar to that of healthy, non-pregnant patients. This could suggest a possible role of UAPI measurement in the ultrasonographic diagnosis of PSTT.