Effects of progesterone, oestradiol benzoate and cloprostenol on luteal function in the heifer

Munro, R. K.; Moore, N. W.

doi:10.1530/jrf.0.0730353

Cited by 31 publications

(4 citation statements)

References 17 publications

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“…These results are consistent with those reported by Burke et al (1999), in which plasma P4 concentrations declined by 2 ng/mL by 2 d after EB injection. Also consistent with our results (Table 4), it was reported that at least 2 d were required for estradiol to suppress endogenous P4 concentration (Munro and Moore, 1985). On d 21, P4 concentrations were already less in the EB − 1.0-treated cows than in controls and remained so for at least 24 h. Concentrations of P4 in estrogen-treated cows declined in a similar rate to the controls, which is consistent with those results reported by Burke et al (1999).…”

Section: Discussionsupporting

confidence: 92%

Resynchronizing Estrus with Progesterone or Progesterone Plus Estrogen in Cows of Unknown Pregnancy Status

El-Zarkouny

Stevenson

2004

Journal of Dairy Science

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Two experiments were conducted to test 2 progesterone (P4)-based treatments that were applied to lactating dairy cattle of unknown pregnancy status to resynchronize estrus of nonpregnant cows. In experiment 1, cows were assigned randomly before a timed AI (TAI) to 1) treatment with a CIDR (controlled internal drug-releasing intravaginal insert containing P4) for 7 d starting on d 13 after TAI (CIDR; n = 300) or 2) no P4 treatment (control; n = 330). Compared with controls, P4 increased the synchrony of those detected in estrus, but failed to increase the overall return rates of non-pregnant cows during the 6 d after CIDR removal (27% vs. 31%; d 20 to 26 after TAI) and did not alter synchronized conception rates (32% vs. 20%) of those inseminated. Use of P4 did not compromise pregnancies resulting from TAI compared with controls (38% vs. 42%), but increased embryo survival between d 29 and 57 after TAI (65.5% vs. 44.3%). In experiment 2, on d 13 after TAI, 196 cows were treated with a CIDR insert for 7 d. Controls received no further treatment. Remaining cows were treated with 1 of 3 estrogen regimens: 1 mg of estradiol benzoate (EB), 0.5 mg of estradiol cypionate (ECP), or 1 mg of ECP on both d 13 and 21. Only 60% of nonpregnant, estrogen-treated cows were detected in estrus between d 20 and 26, and rates of return and conception did not differ among treatments. Estrogen on d 13 did not consistently turn over the dominant follicle when given at CIDR insertion but did increase concentrations of estradiol and reduced luteal function when administered on d 13 and 21 (24 h after CIDR removal). Treatments had no negative effects on milk yield, dry matter intake, or established pregnancies. Use of P4 alone had little effect on overall rates of return to estrus or conception at the first eligible estrus in experiment 1. Combining estrogen with P4 in experiment 2 had no detrimental effects on established pregnancies or subsequent conception and failed to improve return rates beyond P4 alone.

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Section: Discussionsupporting

confidence: 92%

Resynchronizing Estrus with Progesterone or Progesterone Plus Estrogen in Cows of Unknown Pregnancy Status

El-Zarkouny

Stevenson

2004

Journal of Dairy Science

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“…Cows treated with progestagens had a high oestrous induction and synchronization rate (93% overall). This was expected due to the long progestagenic impregnation period and the PG injection at device removal, which avoids the presence of luteal function and enhances oestrous synchronization (Munro and Moore 1985; Larson and Ball 1992; Ryan et al. 1999) and, to the injection of eCG, which promotes ovulation and increases pregnancy rate (Sinclair et al.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Unobserved Oestrus in a Dairy Cattle Herd with Low Oestrous Detection Rate up to 60 days Post‐partum

Mateus¹,

Lopes-da-Costa²,

Cardos³

et al. 2002

Reprod Domestic Animals

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The efficiency of treatments for unobserved oestrus and their effect on the reproductive performance of a dairy cattle herd with low oestrous detection rate till 60 days post-partum (dpp), attributed to the declivous and slippery concrete floor were investigated. The herdsman requested advice in order to improve the mean days open of the herd, but no investments were allowed because a new unit was about to be built. Due to the low oestrus detection rate of the herd, the breeding policy was to inseminate at the first detected post-partum oestrus. Cows were examined at 20-30 dpp to assess uterine involution, ovarian activity and prevalence of reproductive disorders and, at 60 dpp if no previous oestrus was detected. Each examination included palpation per rectum, ultrasound scanning and collection of a blood sample for plasma progesterone (P4) measurement. Cows with unobserved oestrus till 60 dpp were allocated either to a treatment group (n=139) or to a control group (n=139). Three treatments were used: (a) injection of PGF(2 alpha) (PG) upon detection of a corpus luteum (CL; n = 30), cows not observed in oestrus being re-injected 11-12 days later. AI was at oestrus; (b) PRID (n=35) or Crestar (n=74) devices kept in situ for 12 and 9 days, respectively, were associated to an injection of PG and of equine chorionic gonadotrophin (eCG) at device removal. Cows were double-fixed time-inseminated at 48 and 72 h after device removal. All treated cows were examined at 48-72 h after treatment to confirm oestrus. The percentage of cows detected in oestrus up to 60 dpp remained unchanged through the trial (35 and 47% for years before intervention: 1994-95; 51 and 48% for years of intervention: 1996-97). In contrast, the oestrous detection rate was high both in treated (93%) and control (100%) cows. This possibly resulted from an improvement in the oestrous detection efficiency of the herd's personnel and from examination of cows at 48-72 h after treatment. Treated and control cows had identical conception rate (CR; 36 and 37%, respectively) and reproductive performance. However, the mean days open of the herd in 1996 was significantly improved in comparison with previous years (mean +/- SEM: 134 +/- 6, 126 +/- 5, 110 +/- 4 and 114 +/- 5 days, for years 1994, 1995, 1996 and 1997, respectively, p < 0.05, ANOVA). Conception rate to AI up to 40 dpp was significantly reduced, compared with the period between 60 and 100 dpp but, mean days open were significantly improved in cows inseminated up to 60 dpp, compared with thereafter (p < 0.05).

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“…When comparing the efficiency of prostaglandin treatment alone with that of combined progestin–prostaglandin treatment aimed at controlling oestrous cycles in dairy cows, several authors have reported increased synchronization rates and fertility following progesterone plus prostaglandin treatment (Munro and Moore 1985; Ryan et al. 1999).…”

Section: Prostaglandin and Progesterone Treatmentsmentioning

confidence: 99%

Recent Developments in Oestrous Synchronization of Postpartum Dairy Cows with and without Ovarian Disorders

Yániz

Murugavel

López‐Gatius

2004

Reprod Domestic Animals

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This report reviews the most recent developments in prostaglandin-based oestrous synchronization programmes for postpartum dairy cows and addresses the efficiency of controlled breeding protocols based on such developments for cows with abnormal ovarian conditions. A double prostaglandin protocol applied 11-14 days apart seems to be capable of bringing most cows to oestrus. Because of varying oestrus onset times, improved conception rates are obtained following artificial insemination (AI) at detected oestrus rather than fixed-time AI in prostaglandin-treated cows. The administration of oestradiol or human chorionic gonadotrophin, or both these hormones, after prostaglandin treatment, improves the synchrony of oestrus yet does not enhance the conception rate. Progesterone-based treatments for oestrous synchronization are considered the most appropriate for non-cyclic or anoestrous postpartum dairy cows; prostaglandin alone being ineffective because of the absence of a mature corpus luteum in these cows. Improved oestrus synchrony and fertility rate have been reported using short-term progesterone treatment regimes (7-9 days) with or without oestradiol benzoate combined with the use of a luteolytic agent given 1 day before, or at the time of, progesterone withdrawal. The ovulation synchronization (Ovsynch) protocol, based on the use of gonadotrophin releasing hormone and prostaglandin, was developed to coordinate follicular recruitment, CL regression and the time of ovulation. This protocol allows fixed time insemination and has proved effective in improving reproductive management in postpartum dairy cows. However, timed AI following Ovsynch seems to have no beneficial effects in heifers, because of an inconsistent follicle wave pattern, and in anoestrous cows, given their lack of prostaglandin responsive CL. To date, there are several prostaglandin based, fixed-time insemination oestrous synchronization protocols for use in early postpartum dairy cows with ovarian disorders such as ovarian cysts and acyclicity.

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Effects of progesterone, oestradiol benzoate and cloprostenol on luteal function in the heifer

Cited by 31 publications

References 17 publications

Resynchronizing Estrus with Progesterone or Progesterone Plus Estrogen in Cows of Unknown Pregnancy Status

Resynchronizing Estrus with Progesterone or Progesterone Plus Estrogen in Cows of Unknown Pregnancy Status

Treatment of Unobserved Oestrus in a Dairy Cattle Herd with Low Oestrous Detection Rate up to 60 days Post‐partum

Recent Developments in Oestrous Synchronization of Postpartum Dairy Cows with and without Ovarian Disorders

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