Effects of progesterone nanoparticles on the sperm capacitation and acrosome reaction in asthenozoospermia men

Baranizadeh, Khadijeh; Mahboobian, Mohammad Mehdi; Amiri, Iraj; Tavilani, Heidar; Shafiee, Gholamreza

doi:10.1111/and.14258

Cited by 9 publications

(7 citation statements)

References 51 publications

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“…It has been known that the progesterone hormone as a NPs increases the acrosome integrity, sperm capacitation and TAC level, as well as increases the expression of PTK PKA, SPACA1 and P38MAPK genes in the study conducted in asthenospermic humans (Baranizadeh et al 2022).…”

Section: Positive Effect Of Addition Of Nanoparticlesmentioning

confidence: 99%

“…As a result, it has been shown to increase acrosomal reaction, sperm capacitation, and motility, as well as enhance the expression of protein kinase A, protein tyrosine kinase, P38MAPK, and SPACA1 genes in intracellular signaling pathways. It appears that progesterone-loaded solid lipid nanoparticles can be considered a significant and potent factor in sperm capacitation and acrosome reaction (Baranizadeh et al, 2022). Fifteen semen samples from asthenospermia cases were pooled and divided into 10 equal parts.…”

Section: Use Of Nanotechnology In Infertility Treatmentmentioning

confidence: 99%

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Nanotechnology in the Purification of Semen

Bodu,

Ataman,

Bucak

2023

Nanotechnology in Reproduction

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Animals' reduced fertility poses a serious threat to animal reproduction. A number of factors have been demonstrated to reduce semen quality, including age, health, heredity, nutritional condition, seasonal variance, travel stress, artificial insemination (AI), and rising breeding demand. The properties and functioning of semen are altered by the in vitro environment and changes in semen after collection that occur during artificial insemination. Successful artificial insemination may also be achieved via the use of sperm selection and purification techniques. Invasive labeling and/or centrifugation processes are often used in current sperm manipulation approaches, which may be harmful to sperm and/or result in poor recovery rates. The biochemical properties and DNA status of the sperm are often disregarded in favor of selecting for physically normal and motile sperm. It is critical to develop alternative, noninvasive, label-free sperm selection methods to separate sperm based on biochemical features and DNA status. Magnetic nanoparticles provide intriguing new research opportunities for sperm selection. This book explains how sperm may be tagged and cleaned up with the use of nanotechnology, which has become more important in this area in recent years. This book analyzes the recent impact of nanotechnology on sperm labeling, selection, and purification techniques, both existing and planned.

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Section: Positive Effect Of Addition Of Nanoparticlesmentioning

confidence: 99%

Section: Use Of Nanotechnology In Infertility Treatmentmentioning

confidence: 99%

Nanotechnology in the Purification of Semen

Bodu,

Ataman,

Bucak

2023

Nanotechnology in Reproduction

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Section: Positive Effect Of Addition Of Nanoparticlesmentioning

confidence: 99%

Section: Use Of Nanotechnology In Infertility Treatmentmentioning

confidence: 99%

The Positive Effects of In Vivo/In Vitro Suplementation of Nanoparticles on Semen

Koca

2023

Nanotechnology in Reproduction

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Nanoparticles (NPs) are small size molecules. It is divided into organic and inorganic. Organic NPs have many clinical uses, from inoculation to homeostasis, long-term storage and delivery to the system, and absorption of topically used drugs into the skin. Inorganic NPs can be used in intraoperative lymphatic scanning, tumors, and anemia treatments. NPs have a favorable effect on sperm motility, kinematic parameters or membrane integrity rates, they can also be used as antibacterial, antiviral and antifungal in genital organ diseases. There are many studies in which the addition of NPs can be beneficial or harmful to sperm. Researchers have stated that it may be beneficial or cytotoxic depending on in vivo (such as airway, skin or injection) or in vitro use. It has been reported that NPs have positive effects on motility, kinematic parameters, plasma membrane integrity, DNA damage and acrosomal integrity and can be used as an antioxidant. In addition, it has been reported that it can be used in sexsorting, bioimaging and nanopurification, and that more studies on NPs will increase in the coming years.

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“…В последние десятилетия роль прогестерона как важного модулятора мужской эндокринной системы становится все более очевидной. К настоящему времени известно, что прогестерон является важным половым стероидным гормоном не только у женщин, но и у мужчин, существенно влияющим на процессы сперматогенеза (включая регуляцию акросомальной реакции сперматозоидов) и стероидогенеза (биосинтеза тестостерона) в клетках Лейдига яичек [4][5][6].…”

Section: Introductionunclassified

Progesterone and prostate: a history of scientific study and the modern view of the problem

Греков

Tyuzikov

Смирнов

2023

Androl. genit. hir.

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From the moment of discovery until recently, scientific and practical interest in progesterone has been focused exclusively on female reproductive endocrinology and obstetrics and gynecology. At the same time, the potential role of progesterone in the male endocrine, reproductive and genitourinary systems from the standpoint of the historically established interpretation of this sex steroid hormone only as a female steroid with predominantly reproductive and antiproliferative effects has remained in the shadow of research for many decades. However, over the past two decades, interesting data has begun to accumulate that progesterone is just as important for men as for women. Moreover, in both sexes progesterone performs not only classical (reproductive) effects, but also has a wide range of so-called non-classical (non-productive) effects, which make it possible to call it a kind of “gray cardinal” of steroidogenesis. In the review article, based on the available literature, general and particular issues of endocrinology of progesterone in the male body are considered. The questions of the physiological role of progesterone in maintaining the hormonal and metabolic status of the prostate gland and the mechanisms of its participation in the pathogenesis of various prostate diseases are covered in more detail.

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Effects of progesterone nanoparticles on the sperm capacitation and acrosome reaction in asthenozoospermia men

Cited by 9 publications

References 51 publications

Nanotechnology in the Purification of Semen

Nanotechnology in the Purification of Semen

The Positive Effects of In Vivo/In Vitro Suplementation of Nanoparticles on Semen

Progesterone and prostate: a history of scientific study and the modern view of the problem

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