Effects of Probiotics Supplementation on Gastrointestinal Symptoms and SIBO after Roux-en-Y Gastric Bypass: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

Wagner, Nathalia Ramori Farinha; Ramos, Marília Rizzon Zaparolli; Carlos, Lígia de Oliveira; Cruz, Magda Rosa Ramos da; Taconeli, César Augusto; Filho, Alcides José Branco; Nassif, Luis Sérgio; Schieferdecker, Maria Eliana Madalozzo; Campos, Antônio Carlos Ligocki

doi:10.1007/s11695-020-04900-x

Cited by 31 publications

(39 citation statements)

References 35 publications

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“…A previous study has observed a decrease in metabolic endotoxemia and a possible associated decrease in the inflammation and oxidative stress [106]. Bacterial overgrowth is a side effect usually associated to RYGB, probiotic supplementation has been suggested to reduce bacterial overgrowth [109], although other studies did not report this beneficial effect [110].…”

Section: Gut Microbiota Manipulation Complementary To Bariatric Surgerymentioning

confidence: 99%

Shifts in gut microbiota and their metabolites induced by bariatric surgery. Impact of factors shaping gut microbiota on bariatric surgery outcomes

Gutiérrez-Repiso

Moreno-Indias

Tinahones

2021

Rev Endocr Metab Disord

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Evidence suggests that bariatric surgery alters gut microbiota, although its impact at compositional and functional level is not well described. In this review, the most relevant findings, mainly described in Roux-en-Y gastric bypass and sleeve gastrectomy, are outlined. Although the number of studies has increased in the last years, conclusive assertions cannot be elaborated. An issue to address is to know the influence of these alterations on host metabolism and the contribution of gut microbiota derived metabolites. New lines of research have been focusing on analysing gut microbiota functionality rather than evaluating changes at compositional level, and the functions of gut microbiota metabolites in host metabolism, what will bring more relevant information about the influence of gut microbiota in bariatric surgery outcomes. Personalized medicine, because of the predictive value of gut microbiota, is another promising field. The possibility of a specific gut microbiota pattern that could predict type 2 diabetes remission or weight loss failure after bariatric surgery is a matter of great interest. However, little is known about how gut microbiota manipulation could contribute to the beneficial effects of bariatric surgery. Peri-operative antibiotics prophylaxis or probiotic supplementation early after surgery, are strategies barely studied so far, and could constitute a novel tool in the management of weight loss and metabolic profile improvement after surgery.

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Section: Gut Microbiota Manipulation Complementary To Bariatric Surgerymentioning

confidence: 99%

Shifts in gut microbiota and their metabolites induced by bariatric surgery. Impact of factors shaping gut microbiota on bariatric surgery outcomes

Gutiérrez-Repiso

Moreno-Indias

Tinahones

2021

Rev Endocr Metab Disord

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“…Currently, many strategies, such as weight loss drugs (orlistat, sibutramine, and lorcaserin hydrochloride) and bariatric surgery, are used to ameliorate diabetic lipid/metabolic disorders. However, these strategies carry unwanted side effects, such as fatigue, memory difficulty, nausea, diarrhea, and gastrointestinal symptoms. , Therefore, there is urgency in seeking safe and healthy phytochemicals that may alleviate or relieve the GLMD effects of diabetes and obesity.…”

Section: Introductionmentioning

confidence: 99%

“…However, these strategies carry unwanted side effects, such as fatigue, memory difficulty, nausea, diarrhea, and gastrointestinal symptoms. 6,7 Therefore, there is urgency in seeking safe and healthy phytochemicals that may alleviate or relieve the GLMD effects of diabetes and obesity.…”

Section: ■ Introductionmentioning

confidence: 99%

Dietary Luteolin: A Narrative Review Focusing on Its Pharmacokinetic Properties and Effects on Glycolipid Metabolism

Wang

Zeng

Wang

et al. 2021

J. Agric. Food Chem.

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Luteolin, a flavone subclass of flavonoids, is commonly found in food plants and has multiple biological activities. Recently, evidence is growing with regard to the potential of luteolin intake to beneficially affect glycolipid metabolism disorders (GLMDs), particularly insulin resistance, diabetes, and obesity. The aim of this contribution is to provide an overview of recent advances in identifying and understanding the pharmacokinetic properties (absorption, metabolism, and bioavailability) of luteolin, its regulatory effects on glycolipid metabolism, and the underlying mechanisms of action of luteolin in the brain, liver, adipose tissues, and other tissues/organs. Collectively, luteolin or its principal metabolites may contribute to counteracting GLMDs, especially for human obesity and diabetes.

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“…Despite of the existence of research on the influence of diet on enterotypes probiotics have still been examined for the possibility of impacting enterotypes at a similar level. The use of probiotics to modulate the intestinal microbiota and treat gastrointestinal symptoms has been considered an alternative to improve surgical results 24 .…”

Section: Discussionmentioning

confidence: 99%

Are Enterotypes in Obese Modified by Bariatric Surgery, the Use of Probiotic Supplements and Food Habits?

DE-Oliveira

Schieferdecker

Campos

2021

ABCD, arq. bras. cir. dig.

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Introduction: Studies suggest that bariatric surgery, use of probiotic supplements and the dietary pattern can change enterotypes, as well as the entire microbial population. Objective: To verify the influence of bariatric surgery, the use of probiotic supplements and eating habits on enterotypes in obese patients. Methods: Articles published between the 2015 and 2020 were searched in Lilacs and PubMed with the headings: probiotics, eating behavior, food consumption, food, diet, microbiota, gastrointestinal microbiome, bariatric surgery, gastric bypass and the keyword enterotype in Portuguese, English and Spanish. Results: Of the 260 articles found, only studies carried out in obese adults relating changes in the enterotype after bariatric surgery or use of probiotics or dietary patterns and original articles were selected. In the end, eight papers on enterotype change and bariatric surgery were selected and categorized, four on the relationship between food consumption and microbiota and one on the effects of probiotics on enterotypes. Conclusion: The microbial structure is widely modified after bariatric surgery, since the use of probiotic supplement does not bring lasting changes. Enterotypes appear to be shaped by long-term dietary patterns, can modulate how nutrients are metabolized and can be a useful biomarker to improve clinical management.

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Effects of Probiotics Supplementation on Gastrointestinal Symptoms and SIBO after Roux-en-Y Gastric Bypass: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 31 publications

References 35 publications

Shifts in gut microbiota and their metabolites induced by bariatric surgery. Impact of factors shaping gut microbiota on bariatric surgery outcomes

Shifts in gut microbiota and their metabolites induced by bariatric surgery. Impact of factors shaping gut microbiota on bariatric surgery outcomes

Dietary Luteolin: A Narrative Review Focusing on Its Pharmacokinetic Properties and Effects on Glycolipid Metabolism

Are Enterotypes in Obese Modified by Bariatric Surgery, the Use of Probiotic Supplements and Food Habits?

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