Effects of probiotics on methionine cholinedeficient diet-induced steatohepatitis in rats

Karahan, Nermin; Işler, Mehmet; Koyu, Ahmet; Karahan, Aynur Gül; Kılıç, Gülden Başyiğit; Çiriş, İbrahim Metin; Sütçü, Recep; Onaran, İbrahim; Çam, Hakan; Keskın, Muharrem

doi:10.4318/tjg.2012.0330

Cited by 19 publications

(15 citation statements)

References 52 publications

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“…Similar results were obtained by Wang et al who reported that the probiotic mixture, kefir, reduced ovalbumin induced apoptosis in mouse heart tissues by limiting levels of the pro-apoptotic proteins Bax and Bad, cytochrome c and caspase-3 [56]. Administration of probiotic mixtures also depressed expression of apoptosis linked proteins such as pro-apoptotic Bax, caspase-3 and -8, and anti-apoptotic Bcl-2 in the livers of rats fed a methionine choline-deficient diet [57]. The ability of probiotics to modulate apoptotic and anti-apoptotic proteins has also been illustrated in acetaminophen-induced hepatotoxicity [58] and chemotherapy-induced small and large intestinal apoptosis in rats [59].…”

Section: Mechanisms Of Probiotic Actionmentioning

confidence: 99%

Role of Endogenous Microbiota, Probiotics and Their Biological Products in Human Health

2013

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Although gut diseases such as inflammatory bowel disease, mucositis and the alimentary cancers share similar pathogenetic features, further investigation is required into new treatment modalities. An imbalance in the gut microbiota, breached gut integrity, bacterial invasion, increased cell apoptosis to proliferation ratio, inflammation and impaired immunity may all contribute to their pathogenesis. Probiotics are defined as live bacteria, which when administered in sufficient amounts, exert beneficial effects to the gastrointestinal tract. More recently, probiotic-derived factors including proteins and other molecules released from living probiotics, have also been shown to exert beneficial properties. In this review we address the potential for probiotics, with an emphasis on probiotic-derived factors, to reduce the severity of digestive diseases and further discuss the known mechanisms by which probiotics and probiotic-derived factors exert their physiological effects.

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Section: Mechanisms Of Probiotic Actionmentioning

confidence: 99%

Role of Endogenous Microbiota, Probiotics and Their Biological Products in Human Health

2013

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“…Karahan et al . (2012) showed that MCDD-induced NASH in rats improved after treatment with probiotic mixture containing 6 or 13 bacterial strains that were isolated from the healthy human stool samples, likely in part through modulation of TNF-α activity [65]. Dextran sulphate sodium (DSS) treatment of Apolipoprotein E-deficiency mice caused liver histopathological features of steatohepatitis, which were prevented by VSL#3 treatment, through modulation of the expression of nuclear receptors, peroxisome proliferator-activated receptor-γ, Farnesoid-X-receptors, and vitamin D receptor [66].…”

Section: Nutritional Interventionsmentioning

confidence: 99%

Non-Alcoholic Fatty Liver Disease in Children: Focus on Nutritional Interventions

Yang

Gong

et al. 2014

Nutrients

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With increasing prevalence of childhood obesity, non-alcoholic fatty liver disease (NAFLD) has emerged as the most common cause of liver disease among children and adolescents in industrialized countries. It is generally recognized that both genetic and environmental risk factors contribute to the pathogenesis of NAFLD. Recently, there has been a growing body of evidence to implicate altered gut microbiota in the development of NAFLD through the gut-liver axis. The first line of prevention and treatment of NAFLD in children should be intensive lifestyle interventions such as changes in diet and physical activity. Recent advances have been focused on limitation of dietary fructose and supplementation of antioxidants, omega-3 fatty acids, and prebiotics/probiotics. Convincing evidences from both animal models and human studies have shown that reduction of dietary fructose and supplement of vitamin E, omega-3 fatty acids, and prebiotics/probiotics improve NAFLD.

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“…Kim DH et al found that consumption of kefir (a probiotic beverage containing over 50 species of lactic acid bacteria and yeast) prevented obesity and NAFLD formation by restoring gut microbiota and enhancing fatty acid oxidation in HFD-fed mice [98]. Further evidence of beneficial effects on NAFLD prevention has been acquired in many studies by administering probiotics of mixed bacteria [99][100][101]. In addition to the direct impacts on the composition of gut microbiota, the beneficial effects of probiotics on NAFLD are also associated with their metabolic activities [53].…”

Section: Gut Microbiota-targeted Therapies Of Nafldmentioning

confidence: 99%

“…High fat and sucrose diet (HFSD)-induced NAFLD in rats [170] Influencing protein expression and decreasing steatohepatitis MCD diet-induced NASH in rats [99] Reducing obesity-related biomarkers and modulating the microbial community…”

Section: Probiotic Mixturesmentioning

confidence: 99%

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy

Ma¹,

Zhou²,

Li³

2017

Preprint

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Gut microbiota play critical roles in development of obese-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance, which highlighted the potential of gut microbiota-targeted therapies on these diseases. There are various ways that can manipulate gut microbiota including probiotics, prebiotics, synbiotics, antibiotics and some active components from herbal medicines. In this review, we first described the main roles of gut microbiota in mediating the development of NAFLD, and the advances in gut microbiota-targeted therapies in NAFLD in both the experimental and clinical studies, as well as the conclusions on the prospect of gut microbiotatargeted therapies in the future.

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Effects of probiotics on methionine cholinedeficient diet-induced steatohepatitis in rats

Cited by 19 publications

References 52 publications

Role of Endogenous Microbiota, Probiotics and Their Biological Products in Human Health

Role of Endogenous Microbiota, Probiotics and Their Biological Products in Human Health

Non-Alcoholic Fatty Liver Disease in Children: Focus on Nutritional Interventions

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy

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