Effects of probiotics consumption on lowering lipids and CVD risk factors: A systematic review and meta-analysis of randomized controlled trials

Sun, Jing; Buys, Nicholas J.

doi:10.3109/07853890.2015.1071872

Cited by 145 publications

(114 citation statements)

References 41 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…Epidemiological studies have established the clinical benefits of nutrition and functional foods on disease, including the use of probiotics to prevent diseases [50]. Several meta-analyses of randomized controlled trials have shown a benefit of probiotic interventions in various therapeutic areas including neonatology [51], gastroenterology [52], cardiovascular risk factors [53], urinary [54] and respiratory tract [18, 20]. Along with the clinical benefits, functional foods have the potential to impact healthcare costs.…”

Section: Discussionmentioning

confidence: 99%

The Clinical and Economic Impact of Probiotics Consumption on Respiratory Tract Infections: Projections for Canada

Lenoir-Wijnkoop

Gerlier²,

Roy

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

IntroductionThere is accumulating evidence supporting the use of probiotics, which are defined as “live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host”, as a preventive measure against respiratory tract infections (RTI). Two recent meta-analyses showed probiotic consumption (daily intake of 107 to 1010 CFU in any form for up to 3 months) significantly reduced RTI duration, frequency, antibiotic use and work absenteeism.ObjectivesThe aim of this study was to assess the impact of probiotic use in terms of number of RTI episodes and days averted, and the number of antibiotic prescriptions and missed workdays averted, in the general population of Canada. In addition, the corresponding economic impact from both a healthcare payer and a productivity perspective was estimated.MethodsA microsimulation model was developed to reproduce the Canadian population (sample rate of 1/1000 = 35 540 individuals) employing age and gender. RTI incidence was taken from FluWatch consultation rates for influenza-like illness (2013–14) and StatCan all-cause consultations statistics. The model was calibrated on a 2.1% RTI annual incidence in the general population (5.2 million RTI days) and included known risk factors (smoking status, shared living conditions and vaccination status). RTI-related antibiotic prescriptions and work absenteeism were obtained from the literature.ResultsThe results indicate that probiotic use saved 573 000–2.3 million RTI-days, according to the YHEC–Cochrane scenarios respectively. These reductions were associated with an avoidance of 52 000–84 000 antibiotic courses and 330 000–500 000 sick-leave days. A projection of corresponding costs reductions amounted to Can$1.3–8.9 million from the healthcare payer perspective and Can$61.2–99.7 million when adding productivity losses.ConclusionThe analysis shows that the potential of probiotics to reduce RTI-related events may have a substantial clinical and economic impact in Canada.

show abstract

Section: Discussionmentioning

confidence: 99%

The Clinical and Economic Impact of Probiotics Consumption on Respiratory Tract Infections: Projections for Canada

Lenoir-Wijnkoop

Gerlier²,

Roy

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In line with these findings, Cani et al [93] found reduced hunger rates, increased postprandial GLP-1 and PYY, and decreased postprandial glucose responses in healthy volunteers treated with prebiotics. Probiotics, especially Lactobacillus strains, were also found to beneficially affect body weight, glucose-and lipid metabolism, and inflammatory status [94][95][96][97].…”

Section: Pre- Pro- and Antibioticsmentioning

confidence: 99%

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

Fluitman

Clercq

Keijser

et al. 2017

Expert Review of Endocrinology & Metabolism

View full text Add to dashboard Cite

Introduction: Malnutrition refers to both over-and undernutrition and results from a disruption in energy balance. It affects one in three people worldwide and is associated with increased morbidity and mortality. The intestinal microbiota represents a newly identified factor that might contribute to the development of malnutrition, as it harbors traits that complement the human metabolic and endocrine capabilities, thereby influencing energy balance. Areas covered: In the current review, we aim to give a comprehensive overview on the microbiota, its development and its possible influence on energy balance, with emphasis the role of short-chain fatty acids. We also consider microbial characteristics associated with obesity and undernutrition and evaluate microbial manipulating strategies. The PubMed database was searched using the terms:

show abstract

“…A recent meta-analysis found that treatment with probiotics (especially when composed by multiple strains) led to a reduction in several cardiovascular risk factors, including total cholesterol, LDL cholesterol, BMI, waist circumference, and inflammatory markers, compared to placebo [179] . ScFAs (e.g.…”

Section: Probioticsmentioning

confidence: 99%

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities

Slyepchenko

Maes

Jacka

et al. 2016

Psychother Psychosom

192

128

View full text Add to dashboard Cite

Background: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and resultant bacterial translocation add a new element to the bidirectional interactions of the gut-brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), obesity, and type 2 diabetes mellitus (T2DM). Methods: We searched the PubMed/MEDLINE database up until May 1, 2016 for studies which investigated intestinal dysbiosis and bacterial translocation (the ‘leaky gut') in the pathophysiology of MDD and co-occurring somatic comorbidities with an emphasis on IBS, CFS, obesity, and T2DM. Results: The composition of the gut microbiota is influenced by several genetic and environmental factors (e.g. diet). Several lines of evidence indicate that gut-microbiota-diet interactions play a significant pathophysiological role in MDD and related medical comorbidities. Gut dysbiosis and the leaky gut may influence several pathways implicated in the biology of MDD, including but not limited to immune activation, O&NS, and neuroplasticity cascades. However, methodological inconsistencies and limitations limit comparisons across studies. Conclusions: Intestinal dysbiosis and the leaky gut may constitute a key pathophysiological link between MDD and its medical comorbidities. This emerging literature opens relevant preventative and therapeutic perspectives.

show abstract

Effects of probiotics consumption on lowering lipids and CVD risk factors: A systematic review and meta-analysis of randomized controlled trials

Cited by 145 publications

References 41 publications

The Clinical and Economic Impact of Probiotics Consumption on Respiratory Tract Infections: Projections for Canada

The Clinical and Economic Impact of Probiotics Consumption on Respiratory Tract Infections: Projections for Canada

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities

Contact Info

Product

Resources

About