Effects of Probiotics and Prebiotics on Frailty and Ageing: A Narrative Review

Jayanama, Kulapong; Theou, Olga

doi:10.2174/1574884714666191120124548

Cited by 21 publications

(15 citation statements)

References 73 publications

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“…The support of the gut microbiota with probiotics could therefore improve the immunity and help fighting the SARS-CoV-2 infection [111]. The probiotics and prebiotics have been postulated to be beneficial in the frail older persons, however the conclusive evidence as regards the post COVID-19 older patients is still to be obtained [112].…”

Section: Covid-19-related Acute Sarcopeniatowards Prevention and Managementmentioning

confidence: 99%

Post-COVID-19 acute sarcopenia: physiopathology and management

et al. 2021

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In this review, we discuss the pathophysiologic and management aspects of acute sarcopenia in relation to SARS-CoV-2 infection. COVID-19 is as a multi-organ infectious disease characterized by a severe inflammatory and highly catabolic status, influencing the deep changes in the body build, especially the amount, structure, and function of skeletal muscles which would amount to acutely developed sarcopenia. Acute sarcopenia may largely impact patients’ in-hospital prognosis as well as the vulnerability to the post-COVID-19 functional and physical deterioration. The individual outcome of the COVID-19 and the degree of muscle mass and functional loss may be influenced by multiple factors, including the patient’s general pre-infection medical and functional condition, especially in older adults. This paper gathers the information about how the SARS-CoV-2 hyper-inflammatory involvement exacerbates the immunosenescence process, enhances the endothelial damage, and due to mitochondrial dysfunction and autophagy, induces myofibrillar breakdown and muscle degradation. The aftermath of these acute and complex immunological SARS-CoV-2-related phenomena, augmented by anosmia, ageusia and altered microbiota may lead to decreased food intake and exacerbated catabolism. Moreover, the imposed physical inactivity, lock-down, quarantine or acute hospitalization with bedrest would intensify the acute sarcopenia process. All these deleterious mechanisms must be swiftly put to a check by a multidisciplinary approach including nutritional support, early physical as well cardio-pulmonary rehabilitation, and psychological support and cognitive training. The proposed holistic and early management of COVID-19 patients appears essential to minimize the disastrous functional outcomes of this disease and allow avoiding the long COVID-19 syndrome.

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Section: Covid-19-related Acute Sarcopeniatowards Prevention and Managementmentioning

confidence: 99%

Post-COVID-19 acute sarcopenia: physiopathology and management

et al. 2021

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“…A randomised controlled trial of a prebiotic (fructooligosaccharides) supplement for 13 weeks in sixty frail adults aged 65 years or older reported significant improvements in two frailty criteria, exhaustion (fatigue score; pre1.4 ± 1.7 post0.8 ± 1.4, p < 0.05) and handgrip strength (pre10.6 ± 8.2, post12.4 ± 3.2, p < 0.05), and also a reduction in overall frailty index score (pre0.22 ± 0.09, post0.20 ± 0.08, p < 0.001), versus those given placebo [ 129 , 130 ]. While there are no studies to our knowledge testing other prebiotic supplements, or probiotic supplements for reduction of frailty, there is some limited evidence that such supplements may improve other age-related conditions that may contribute to overall frailty, such as cognition and bone health, and this has been summarised recently by Jayanama et al [ 131 ]. The crucial point is that the gut microbiome is potentially malleable , and can be targeted using dietary changes, prebiotics, probiotics, and even faecal microbial transplants, thus representing an exciting therapeutic target for preventing and treating frailty.…”

Section: Can Dietary Change Be Used To Prevent and Treat Frailty?mentioning

confidence: 99%

Nutrition and Frailty: Opportunities for Prevention and Treatment

et al. 2021

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Frailty is a syndrome of growing importance given the global ageing population. While frailty is a multifactorial process, poor nutritional status is considered a key contributor to its pathophysiology. As nutrition is a modifiable risk factor for frailty, strategies to prevent and treat frailty should consider dietary change. Observational evidence linking nutrition with frailty appears most robust for dietary quality: for example, dietary patterns such as the Mediterranean diet appear to be protective. In addition, research on specific foods, such as a higher consumption of fruit and vegetables and lower consumption of ultra-processed foods are consistent, with healthier profiles linked to lower frailty risk. Few dietary intervention studies have been conducted to date, although a growing number of trials that combine supplementation with exercise training suggest a multi-domain approach may be more effective. This review is based on an interdisciplinary workshop, held in November 2020, and synthesises current understanding of dietary influences on frailty, focusing on opportunities for prevention and treatment. Longer term prospective studies and well-designed trials are needed to determine the causal effects of nutrition on frailty risk and progression and how dietary change can be used to prevent and/or treat frailty in the future.

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“…There is an increasing awareness of the benefits of prophylactic use of probiotics in maintaining health and improving quality of life in the elderly population [ 33 , 34 , 35 , 36 ]. As summarized in Table 1…”

Section: Current Status Of Efforts On Geroscience Globallymentioning

confidence: 99%

Gerobiotics: probiotics targeting fundamental aging processes

Tsai¹,

Cheng

Liu³

et al. 2021

Bioscience of Microbiota, Food and Health

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Aging is recognized as a common risk factor for many chronic diseases and functional decline. The newly emerging field of geroscience is an interdisciplinary field that aims to understand the molecular and cellular mechanisms of aging. Several fundamental biological processes have been proposed as hallmarks of aging. The proposition of the geroscience hypothesis is that targeting holistically these highly integrated hallmarks could be an effective approach to preventing the pathogenesis of age-related diseases jointly, thereby improving the health span of most individuals. There is a growing awareness concerning the benefits of the prophylactic use of probiotics in maintaining health and improving quality of life in the elderly population. In view of the rapid progress in geroscience research, a new emphasis on geroscience-based probiotics is in high demand, and such probiotics require extensive preclinical and clinical research to support their functional efficacy. Here we propose a new term, “gerobiotics”, to define those probiotic strains and their derived postbiotics and para-probiotics that are able to beneficially attenuate the fundamental mechanisms of aging, reduce physiological aging processes, and thereby expand the health span of the host. We provide a thorough discussion of why the coining of a new term is warranted instead of just referring to these probiotics as anti-aging probiotics or with other similar terms. In this review, we highlight the needs and importance of the new field of gerobiotics, past and currently on-going research and development in the field, biomarkers for potential targets, and recommended steps for the development of gerobiotic products. Use of gerobiotics could be a promising intervention strategy to improve health span and longevity of humans in the future.

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Effects of Probiotics and Prebiotics on Frailty and Ageing: A Narrative Review

Cited by 21 publications

References 73 publications

Post-COVID-19 acute sarcopenia: physiopathology and management

Post-COVID-19 acute sarcopenia: physiopathology and management

Nutrition and Frailty: Opportunities for Prevention and Treatment

Gerobiotics: probiotics targeting fundamental aging processes

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