Effects of probiotic Lactiplantibacillus plantarum IMC 510 supplementation on metabolic factors in otherwise healthy overweight and obese individuals

Abstract

Aims: Probiotic supplementation approach offers the possibility to shape the gut microbiota (GM), enabling the development of innovative formulations able to improve intestinal well-being and consequently the related body weight modulation and energy metabolism. In the present clinical study, a new potential probiotic supplement based on Lactiplantibacillus plantarum IMC 510 was studied for weight management. Methods and Results:Quantitative characterization by qPCR of representative bacterial groups of GM was used to determine the microbiota modulation at different supplementation periods. Furthermore, measurement of the endpoints linked to weight control (body mass index, body weight, waist circumference) was assessed. Specific questionnaires to evaluate the impact on psychological and physiological point of view were performed. Results showed that after 90 days, Lact. plantarum IMC 510 supplementation brought an improvement in endpoints linked to weight control and healthy status, although no significant changes in the microbiota composition were reported for analysed bacterial groups, except for Lactobacillus spp. and Bifidobacterium spp. Conclusions:We concluded that Lact. plantarum IMC 510 supplementation could be an interesting tool for weight management. More studies are needed to understand the impact on GM, for example, evaluating the production of short-chain fatty acids, since their important role in dietary metabolism. Further research is necessary to better elucidate the relationship between GM and overweight and the mechanism of action by which Lact. plantarum IMC 510 modifies body weight.Significance and Impact of the Study: However, these promising outcomes represent a clear advantage of probiotic supplementation and identify a new potential probiotic as a novel and safe therapeutic approach in the obesity prevention and management.

Effects of the probiotic Lactiplantibacillus plantarum IMC 510® on body composition, biochemical parameters, gut microbiota composition and function, and clinical symptoms of overweight/obese subjects

“…First, regarding the anthropometric parameters, we found that probiotic supplementation resulted in a slight reduction in body weight, BMI, WHt ratio, and fat mass, confirming our previous findings that documented a clear significant reduction in body weight gain, BMI, and white adipose tissue weight in obese rats after 84 days of Lactiplantibacillus plantarum IMC 510® supplementation ( 15 ) and in human subjects after 3 months of Lactiplantibacillus plantarum IMC 510® administration ( 16 ).…”

“…In addition, in accordance with Coman et al ( 16 ), probiotic supplementation has also determined a significant decrease in the waist circumference of volunteers compared to placebo. Waist circumference and WHtR are used in clinical practice as markers of visceral adiposity, tightly associated with obesity and related metabolic diseases, and the reduction of these two parameters provides important cardiovascular benefits to obese individuals ( 28 ).…”

“…However, although is well established that microbial metabolites, especially SCFAs which can enter the bloodstream and reduce appetite and energy intake, and specific GM bacteria can reduce diet-induced obesity through increased energy expenditure, the mechanisms by which probiotic supplementation can affect the GM of overweight or obese individuals are still largely unknown ( 14 ). Nevertheless, our preliminary data showed that the supplementation of a novel probiotic formulation based on Lactiplantibacillus plantarum IMC 510® determined a significant reduction in weight and food intake in obese rats and body weight, body mass index (BMI) and waist circumferences in a restricted cohort of overweight/obese subjects ( 15 , 16 ).…”

Effects of probiotics on intermediate disease markers in individuals with overweight and obesity: systematic review and meta-analysis

“…Italy [30], Japan [31][32][33][34], Indonesia [35], India [36], Iran [37], Tunisia [38] and United Kingdom [39]. Probiotic intervention duration varies from four weeks to six months.…”

The relationship between oxidative balance scores and chronic diarrhea and constipation: a population-based study

“…Gao Q's study revealed that, compared with that in healthy controls, the expression of NADPH oxidase (a key enzyme that produces ROS) was significantly greater in patients with chronic constipation, and it was suggested that NADPH oxidase may cause constipation by leading to dysbiosis of the gut microbiota [22]. OBS is composed of pro-oxidants (total fat, iron, alcohol intake, BMI, and cotinine) and antioxidants (dietary fiber, β-carotene, vitamin B2, niacin, vitamin B6, total folate, vitamin B12, vitamin C, vitamin E, calcium, magnesium, zinc, copper, selenium, and physical activity), and most of these elements have been proven to affect intestinal health, leading to changes in bowel habits [23][24][25].…”