Effects of Probiotic and Selenium Co-supplementation on Lipid Profile and Glycemia Indices: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Abstract

Purpose of Review The current systematic review and meta-analysis was done to evaluate the effects of selenium and probiotic co-supplementation on lipid profile and glycemia indices of the adult population using randomized controlled clinical trials (RCTs). Recent Findings Five studies involving 282 participants with a sample size ranging from 38 to 79 were eligible to be enrolled in the current study. Co-supplementation with probiotic and selenium reduced fasting plasma glucose (WMD = −4.02 mg/dL; 95% CI: −5.87 to −2.18; P < 0.001), insulin (WMD = −2.50 mIU/mL; 95% CI: −3.11 to −1.90; P < 0.001), homeostatic model assessment for insulin resistance (WMD = −0.59; 95% CI: −0.74 to −0.43; P < 0.001), quantitative insulin sensitivity check index (WMD = 0.01; 95% CI: 0.01 to 0.02; P < 0.001), total cholesterol (WMD = −12.75 mg/dL; 95% CI: −19.44 to −6.07; P < 0.001), low-density lipoprotein cholesterol (WMD = −7.09 mg/dL; 95% CI: −13.45 to −0.73; P = 0.029), and triglyceride (WMD = −14.38 mg/dL; 95% CI: −23.13 to −5.62; P = 0.001). Summary The findings of the current systematic review and meta-analysis suggested that co-supplementation with probiotics and selenium may benefit adults in terms of glycemia indices and lipid profile. However, due to the small number of included studies, further trials are needed to confirm our findings.

The Importance of Micronutrient Adequacy in Obesity and the Potential of Microbiota Interventions to Support It

“…Also, a meta-analysis of five studies published up to February 2022 where joint probiotic and Se (at 50-200 µg/day) supplementations in groups of adults representing various populations were applied showed that the treatment resulted in a significant WMD of FG (−4.0 mg/dL), FI (−2.5 µIU/mL), HOMA-IR (−0.6), TG (−14.4 mg/dL), TC (−12.8 mg/dL), and LDL (−7.1 mg/dL) [187]. All of these values except for FI and HOMA-IR were much greater than those found by meta-analyses studying the effects of Se alone (see Tables 5 and 6), suggesting that joint Se and probiotic treatment may indeed be more effective in improving the homeostasis of glucose and lipids.…”