Effects of prior aerobic exercise on sitting-induced vascular dysfunction in healthy men

Ballard, Kevin D.; Duguid, R.; Berry, Craig W.; Dey, Priyankar; Bruno, Richard S.; Ward, Rose Marie; Timmerman, Kyle L.

doi:10.1007/s00421-017-3738-2

Cited by 26 publications

(69 citation statements)

References 35 publications

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“…This lower limb vascular dysfunction as a result of prolonged sitting has conclusively been determined, in adults, to be due to alterations in shear patterns (Restaino et al 2016). Interventions focused on increasing or maintaining shear patterns before, throughout, or after prolonged sitting bouts have been successful in attenuating vascular dysfunction (Restaino et al 2015(Restaino et al , 2016Thosar et al 2015a;Morishima et al 2016Morishima et al , 2017Ballard et al 2017). Interestingly, the current study revealed no alterations in shear values throughout the 3 h sitting bout when examined as mean shear, antegrade shear, retrograde shear, or oscillatory shear index.…”

Section: Pre Mid Post Anovamentioning

confidence: 41%

“…It has been demonstrated that prolonged sitting significantly alters blood flow patterns in as little as 10 min (Vranish et al 2017), primarily through reductions in mean shear values, and results in considerable macro-and microvascular dysfunction of the lower limb arteries (superficial femoral, popliteal) measured 1-3 h after the onset of sitting (Ballard et al 2017;Morishima et al 2016Morishima et al , 2017Restaino et al 2015Restaino et al , 2016Thosar et al 2015a;Vranish et al 2017). This lower limb vascular dysfunction as a result of prolonged sitting has conclusively been determined, in adults, to be due to alterations in shear patterns (Restaino et al 2016).…”

Section: Pre Mid Post Anovamentioning

confidence: 99%

“…Shear rate reductions during prolonged sitting are rapid (10-30 min) when evaluated at the popliteal artery, which is distal to the CFA (Morishima et al 2017;Vranish et al 2017). Recently, a study that observed lower limb vascular dysfunction as a result of prolonged sitting did not report significant shear reductions until 3 h into the sitting bout when measured at the superficial femoral artery (Ballard et al 2017), highlighting less observable shear alterations in more proximal arteries. Thus, future studies using the PLM technique to evaluate prolonged sitting bouts may need to use additional distal artery (superficial femoral or popliteal) ultrasound scanning to quantify shear rate alterations between groups.…”

Section: Pre Mid Post Anovamentioning

confidence: 99%

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Aerobic training status does not attenuate prolonged sitting-induced lower limb vascular dysfunction

Garten

Hogwood

Weggen

et al. 2019

Appl. Physiol. Nutr. Metab.

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This study examined if the degree of aerobic training protects against the lower limb vascular dysfunction associated with a prolonged sitting bout. Ten young, aerobically trained (AT) and 10 young, untrained (UT) individuals completed a prolonged (3 h) sitting bout. Leg vascular function was measured prior to and at 1.5 and 3 h into the prolonged sitting bout using the passive leg movement (PLM) technique. PLM-induced hyperemia was significantly reduced from baseline at 1.5 and 3 h into the prolonged sitting bout in both groups when evaluated as peak change in leg blood flow from baseline (Δ LBF) (UT: 956 ± 140, 586 ± 80, and 599 ± 96 mL·min−1 at baseline, 1.5 h, and 3 h, respectively; AT: 955 ± 183, 789 ± 193, and 712 ± 131 mL·min−1 at baseline, 1.5 h, and 3 h, respectively) and LBF area under the curve (UT: 283 ± 73, 134 ± 31, and 164 ± 42 mL·min−1 at baseline, 1.5 h, and 3 h, respectively; AT: 336 ± 86, 242 ± 86, and 245 ± 73 mL·min−1 at baseline, 1.5 h, and 3 h, respectively), but no significant differences between groups were revealed. No significant correlations were observed when examining the relationship between maximal oxygen uptake (relative and absolute) and reductions in leg vascular function at 1.5 and 3 h into the prolonged sitting bout. This study revealed that aerobic training did not provide a protective effect against prolonged sitting-induced lower limb vascular dysfunction and further highlights the importance of reducing excessive sitting in all populations.

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Section: Pre Mid Post Anovamentioning

confidence: 41%

Section: Pre Mid Post Anovamentioning

confidence: 99%

Section: Pre Mid Post Anovamentioning

confidence: 99%

See 1 more Smart Citation

Aerobic training status does not attenuate prolonged sitting-induced lower limb vascular dysfunction

Garten

Hogwood

Weggen

et al. 2019

Appl. Physiol. Nutr. Metab.

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“…Although previous studies administering an intervention to further reduce mean shear stress (58,68,69,85) or increase retrograde shear in the superficial femoral artery have observed a reduction in FMD (74,88,89), the perturbations were greater than the changes we observed on ascent. With respect to a vasoprotective effect of trekking, prior exercise prevents shear-mediated impairments in FMD (8,55,58). Further, two weeks of treadmill and cycle training improves popliteal artery FMD (86), thus it is possible that there was some localized training stimulus in the exercised limb that protected or offset the detrimental resting shear stress profile and other harmful stimuli (i.e.…”

Section: Flow-mediated Dilation On Ascent To High Altitudementioning

confidence: 99%

UBC-Nepal expedition: upper and lower limb conduit artery shear stress and flow-mediated dilation on ascent to 5,050 m in lowlanders and Sherpa

Tremblay

Hoiland

Carter

et al. 2018

American Journal of Physiology-Heart and Circulatory Physiology

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The study of conduit artery endothelial adaptation to hypoxia has been restricted to the brachial artery, and comparisons to highlanders have been confounded by differences in altitude exposure, exercise, and unknown levels of blood viscosity. To address these gaps, we tested the hypothesis that lowlanders, but not Sherpa, would demonstrate decreased mean shear stress and increased retrograde shear stress, and subsequently reduced flow-mediated dilation (FMD), in the upper and lower limb conduit arteries on ascent to 5050m. Healthy lowlanders (n=22, 28±6 years [mean±SD]) and Sherpa (n=12, 34±11 years) ascended over 10 days, with measurements taken on non-trekking days at 1400m (baseline), 3440m (day 4), 4371m (day 7), and 5050m (day 10). Arterial blood gases, blood viscosity, shear stress and FMD (duplex ultrasound of the brachial [BA] and superficial femoral [SFA] arteries) were acquired at each time-point. Ascent decreased mean and increased retrograde shear stress in the upper and lower limb of lowlanders and Sherpa. Although BA FMD decreased in the lowlanders from 7.1±3.9% to 3.8±2.8% at 5050m versus 1400m (P<0.001), SFA FMD was preserved. In the Sherpa, neither BA nor SFA FMD were changed upon ascent to 5050m. In lowlanders, the ascent-related exercise may favorably influence endothelial function in the active limb (SFA); selective impairment in FMD in the BA in lowlanders is likely mediated via the low mean or high oscillatory baseline shear stress. In contrast, Sherpa presented protected endothelial function, suggesting a potential vascular aspect of high-altitude acclimatization/adaptation.

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“…In 1 to 4 hours, sitting reduces vascular function by up to 4%, as measured by flow mediated dilation (FMD) (Restaino et al, 2015;Thosar et al, 2015). This reduced vascular function may be partially moderated by a systemic vasoconstrictor response, as evidenced by increased endothelin-1(ET-1) after 2 hours of sitting (Ballard et al, 2017). In addition, arterial stiffness, as measured by pulse wave velocity (PWV), increases in the lower limbs after 2 hours of standing (Caldwell et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Combined Effects of Standing and Passive Heating on Attenuating Sitting-Induced Vascular Dysfunction

Caldwell

Jansen

Rosa‐Caldwell

et al. 2020

Preprint

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What is the central question of this study?Prolonged sitting can cause acutely vascular dysfunction while interventions such as local heating or standing have been explored they have not been used in combination and the role of biological sex has not been fully explored. What is the main finding and its importance?In this study we demonstrate that either local heating or standing are effective at reducing some of the vascular dysfunction associated with prolonged sitting. Biological sex did not appear appear to play a role in this response. However, standing may also cause some negative effects such as increased arterial stiffness and increase the risk of syncope. AbstractRecent evidence suggests prolonged sitting strains the arteries through angulations that create turbulent blood flow. This turbulent flow reduces flow-mediated dilation (FMD), a key indicator of vascular health. The purpose of this study was to determine if arterial angulations (through sitting or standing), shear stress (through local heating), or a combination of these factors affected vascular function. In addition, we sought examined the impact of biological sex on these responses. Methods: Twenty-six healthy, young (18-40 years old) males (n=13) and females (n=13) participated. Participants completed two experimental trials (2-h sitting and 2-h standing), and, in a randomized fashion, one leg was passively heated. Flow-mediated dilation (FMD) at the superficial femoral artery (SFA), and central and peripheral pulse-wave velocity (PWV) were measured using vascular ultrasound. Results: There was a non-significant decrease in FMD (-1.48%; p = .06) during sitting and the decline in FMD was not different between biological sexes (-1.96% vs -0.93%; p = .49, males and females respectively). Passive heating (1.42%; p < .05) and standing (1.42%; p < .05) both improved FMD in comparison to sitting. However, standing resulted in a significant increase in peripheral PWV (50 cm/s; p < .05). Interestingly, the standing was not well tolerated among female participants with seven participants having to stop their initial trial early due to lightheadedness. Conclusions: Both interventions appear to be equally effective at mitigating reductions FMD associated with sitting, but standing increased peripheral PWV. In addition, it does not appear that biological sex moderates these physiological responses. Word limit: 250Sitting Vascular Dysfunction Teixeira, A. L., Padilla, J., & Vianna, L. C. (2017). Impaired popliteal artery flow-mediated dilation caused by reduced daily physical activity is prevented by increased shear stress.

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Effects of prior aerobic exercise on sitting-induced vascular dysfunction in healthy men

Abstract: Prior aerobic exercise prevented the decline in femoral artery FMD that is otherwise induced by prolonged sitting independent of changes in oxidative stress, ET-1, and NO status.

Cited by 26 publications

References 35 publications

Aerobic training status does not attenuate prolonged sitting-induced lower limb vascular dysfunction

Aerobic training status does not attenuate prolonged sitting-induced lower limb vascular dysfunction

UBC-Nepal expedition: upper and lower limb conduit artery shear stress and flow-mediated dilation on ascent to 5,050 m in lowlanders and Sherpa

Combined Effects of Standing and Passive Heating on Attenuating Sitting-Induced Vascular Dysfunction

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