Effects of priming injections of MDMA and cocaine on reinstatement of MDMA- and cocaine-seeking in rats

Schenk, Susan; Hely, Lincoln S.; Gittings, David; Lake, Barbara; Daniela, Evangeline

doi:10.1016/j.drugalcdep.2008.03.014

Cited by 45 publications

(45 citation statements)

References 47 publications

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“…Drug seeking has also been demonstrated following MDMA self-administration in laboratory rats exposed to cues that had been paired with self-administered MDMA (Ball et al 2007 ;Schenk et al 2008), mice exposed to MDMA following extinction of place conditioning (Daza-Losada et al 2007) and monkeys (Banks et al 2008c) and rats (Schenk et al 2008) exposed to priming injections of MDMA following extinction of self-administration.…”

Section: Introductionmentioning

confidence: 96%

Drug seeking in response to a priming injection of MDMA in rats: relationship to initial sensitivity to self-administered MDMA and dorsal striatal dopamine

Colussi-Mas

Wise

Howard

et al. 2010

Int. J. Neuropsychopharm.

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In laboratory animals, exposure to priming injections of 3,4-methylenedioxymethamphetamine (MDMA) produced drug seeking following extinction of MDMA self-administration. This study aimed to evaluate whether the magnitude of drug seeking was related to latency to acquisition of MDMA self-administration and increases in striatal dopamine, as measured by in-vivo microdialysis. Rats were given daily access to MDMA self-administration until they earned a total of 240 infusions (total intake of 165 mg/kg MDMA). Twelve of the 20 rats acquired self-administration within the temporal limits of the study and the latency to meet the criterion ranged from 9 d to 37 d. An experimenter-administered injection of MDMA (10.0 mg/kg i.p.) produced drug seeking in these rats, and the number of responses was significantly higher than responses produced by rats that failed to meet the criterion or by yoked control rats that received the drug passively. For rats that met the criterion, drug seeking was negatively correlated with the number of days to self-administer the criterion number of MDMA infusions and positively correlated with MDMA-produced dopamine in the dorsal striatum. Importantly, MDMA-produced dopamine overflow was greater for the rats that met the criterion. These findings suggest that drug seeking is influenced by initial sensitivity to the reinforcing effects of MDMA and to drug-produced increases in striatal dopamine.

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Section: Introductionmentioning

confidence: 96%

Drug seeking in response to a priming injection of MDMA in rats: relationship to initial sensitivity to self-administered MDMA and dorsal striatal dopamine

Colussi-Mas

Wise

Howard

et al. 2010

Int. J. Neuropsychopharm.

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“…Continued presentation of the drug-associated light stimulus contingent on a lever response maintained responding even in the absence of the drug infusion, supporting the idea that this stimulus had acquired conditioned reinforcing properties and conditioned reinforcers played an important role in the maintenance of MDMA self-administration. These stimuli also appear important in drug-seeking, since their presentation reinstated extinguished MDMA self-administration behavior [49,52] .…”

Section: Maintenance Of Mdma Self-administration In Laboratory Animalsmentioning

confidence: 99%

“…Other research has also reported reliable self-administration [48][49][50][51] but as has been found in primate studies, responding initially maintained by MDMA is usually lower than that maintained by other psychostimulant drugs. With extended testing, however, we and others [46,49] have routinely found an escalation of intake in some subjects such that eventually high doses of 25-50 mg/kg are self-administered [44,45,52] . A question of interest concerns why this escalation occurs.…”

Section: Acquisition Of Mdma Self-administration In Laboratory Animalsmentioning

confidence: 99%

MDMA Self-Administration in Laboratory Animals: A Summary of the Literature and Proposal for Future Research

Schenk

2009

Neuropsychobiology

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The prevalence of 3,4-methylenedioxymethamphetamine (MDMA) use has increased globally and the pattern of consumption has changed considerably. Previously, a subculture of MDMA users was fairly restricted to the dance club scene. More recently, use has spread outside of this subculture and now many users consume MDMA frequently and in large amounts and some meet criteria for drug abuse and/or dependence. Because of confounds associated with studying drug users and abusers, animal models have been employed to investigate potential consequences of drug-taking. Among these, self-administration by laboratory animals has been shown to have excellent predictive validity. There have, however, been mixed results with respect to the ability of MDMA to support and maintain self-administration by laboratory animals. This paper reviews the literature on MDMA self-administration in laboratory primates and rodents. Most of the studies in laboratory animals suggest that only low levels of MDMA are self-administered on a daily basis but some have indicated high levels of self-administered MDMA in certain subjects. Differences might be dependent upon the number of test sessions, prior training conditions or other paradigmatic variables. In most cases, MDMA was found to be a lower efficacy reinforcer than other drugs of abuse. It is suggested that the MDMA self-administration develops following a decrease in MDMA-produced serotonin release that occurs with repeated exposure over an extended period of testing. It is hypothesized that the deficit in central serotonin increases the relative MDMA-produced dopamine responses and that this increase in the dopamine response underlies the development and maintenance of MDMA self-administration.

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“…On the basis of these findings, it might have been expected that the 5-HT antagonist, WAY 100635, would have increased MDMA-produced drug-seeking. Because the dose of MDMA used in this study was relatively high (10.0 mg/kg), a potentiated response might not have been observed due to a ceiling effect (Schenk et al, 2008). Alternatively, the failure to observe an…”

Section: Serotonin and Self-administrationmentioning

confidence: 80%

“…Daily sessions were increased to 6 hr for some additional groups of rats. Drug-seeking tests were conducted during a recurring series comprising baseline (Phase 1; FR5), extinction (ext; Phase 2), and reinstatement (Phase 3) phases, as previously reported (Schenk et al, 2008;2011). Phase 1 consisted of at least two days of responding that was reinforced according to an FR5 schedule by an infusion of MDMA or cocaine (0.5 mg/kg/infusion) and the illumination of the drug-associated light stimulus.…”

Section: Methodsmentioning

confidence: 99%

Serotonin antagonists fail to alter MDMA self-administration in rats

Schenk

Foote

Aronsen

et al. 2016

Pharmacology Biochemistry and Behavior

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Effects of priming injections of MDMA and cocaine on reinstatement of MDMA- and cocaine-seeking in rats

Cited by 45 publications

References 47 publications

Drug seeking in response to a priming injection of MDMA in rats: relationship to initial sensitivity to self-administered MDMA and dorsal striatal dopamine

Drug seeking in response to a priming injection of MDMA in rats: relationship to initial sensitivity to self-administered MDMA and dorsal striatal dopamine

MDMA Self-Administration in Laboratory Animals: A Summary of the Literature and Proposal for Future Research

Serotonin antagonists fail to alter MDMA self-administration in rats

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