Effects of primary suture and fibrin sealant on hemostasis and liver regeneration in an experimental liver injury

Demırel, Arif Hakan; Basar, Ozgur Taylan; Öngören, Ali Ulvi; Bayram, Erkut; Kısakürek, Mustafa

doi:10.3748/wjg.14.81

Cited by 17 publications

(16 citation statements)

References 26 publications

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“…This is similar to a study performed on 120 patients with penetrating liver injuries which revealed that firearm injuries tops the list of penetrating trauma patients, constituting 75 % of the total patients [13].…”

Section: Discussionsupporting

confidence: 88%

Management of Liver Trauma in Minia University Hospital, Egypt

2015

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The aim of this study is to present the outcome of operative and non-operative management of patients with liver injury treated in a single institution depending on imaging. This study was conducted at the Causality Unit of Minia University Hospital, and included 60 patients with hepatic trauma from March 2012 to January 2013. In our study, males represent 80 % while females represent 20 % of the traumatized patients. The peak age for trauma found was 11-30 years. Blunt trauma is the most common cause of liver injury as it was the cause in 48 patients (80 %). Firearm injuries are the most common cause of penetrating trauma (60 %) followed by stab injuries (40 %). More than one half of our patients (34 out of 60) were treated with non-operative management (NOM) with a high success rate. The operative procedures done were suture hepatorrhaphy (20 cases), non-anatomical resection in one case, anatomical resection in one case, and damage control therapy using pads in two cases. In another two cases, nothing was done as subcapsular hematoma had resolved. Minia University Hospital is a big tertiary Hospital in Egypt at which blunt liver trauma is more common than penetrating liver trauma. Surgery is no longer the only option available. It has been reserved for extensive lesions with condition of hemodynamic instability or for the treatment of the complications. NOM is an effective treatment modality in most cases.

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Section: Discussionsupporting

confidence: 88%

Management of Liver Trauma in Minia University Hospital, Egypt

2015

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“…Fibrin sealants are readily available biological sealants which can be safely used for hemostasis, tissue sealing and engineering [10,19]. Besides, it is a biodegradable product that may stimulate fibroblast growth, and thus decrease the number of adhesions [20].…”

Section: Discussionmentioning

confidence: 99%

“…Fibrin sealants (Tisseel, Baxter Biosciences, Vienna, Austria) are biological sealants which can be safely used for hemostasis and tissue sealing [7,10]. In the present study, we aimed to evaluate the effects of fibrin sealant spraying on postoperative air leak in patients undergoing pulmonary resection for non-small cell lung cancer (NSCLC).…”

Section: Introductionmentioning

confidence: 99%

The effect of fibrin sealant spraying on prolonged air leak after pulmonary resections: a single center experience

Kumbasar¹,

Yilmaz²,

Ozercan³

et al. 2017

Curr Thorac Surg

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“…Suas propriedades hemostática, oclusiva, adesiva, promotora da cicatrização (estímulo ao crescimento dos fibroblastos) e antisséptica conferem-lhe uma gama de aplicações clínicas 6,17 .…”

Section: Adesivos De Fibrinaunclassified

“…Trabalhos mostram menor intensidade de aderências quando a fibrina é aplicada. Os escores histopatológicos também foram melhores quando comparados com a sutura convencional 6 . Têm sido utilizados em complicações de anastomoses pancreáticas com resultados satisfatórios.…”

Section: Adesivos De Fibrinaunclassified

Uso de adesivos teciduais em cirurgia digestiva

Soares-Junior

Gomes

Peixoto

et al. 2010

ABCD, arq. bras. cir. dig.

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DESCRITORESAdesivo. Trato gastrointestinal. Anastomose cirúrgica. Fístula.RESUMO -Introdução: Apesar dos refinamentos em cirurgia gastrointestinal, vazamentos anastomóticos persistem como grave problema, associados à morbidade e mortalidade elevadas e constituem a complicação mais temida. Na tentativa de prevenir e reduzir estas complicações, diversidade de técnicas de reforço anastomótico tem sido investigada e diversas medidas auxiliares têm sido desenvolvidas. Objetivo -Revisar os dados associados a aplicação de adesivos em cirurgia digestiva. Método -Revisão bibliográfica de artigos disponíveis no Medline/Pubmed utilizando-se os descritores: adesivo, trato gastrointestinal, anastomose cirúrgica e fístula. Foram selecionados os artigos mais atualizados sobre o assunto os quais utilizaram adesivos como estratégia para reduzir a morbidade e mortalidade relacionada à cirurgia digestiva. Conclusão -Adesivos teciduais parecem seguros na prática clínica e têm sido utilizados com crescente frequência em várias especialidades cirúrgicas em decorrência de suas propriedades hemostáticas e selante, ganhando cada vez maior aceitação por parte dos cirurgiões. Estudos sugerem que adesivos cirúrgicos podem reforçar e melhorar a cicatrização de anastomoses intestinais, elevando a pressão de ruptura e aumentando a força tênsil. Os potenciais efeitos deletérios teciduais destas substâncias podem limitar sua utilização. Em decorrência da heterogeneidade dos estudos e falta de evidência forte, novas pesquisas deverão ser desenvolvidas.ABSTRACT -Background -Despite refinements in the field of gastrointestinal surgery, anastomotic leakage still remains a serious problem associated with substantial morbidity and mortality and is the fearest life threatening complication in digestive surgery. To prevent or reduce these complications, a diversity of line reinforcement techniques have been investigated and several adjunctive measures have been developed. Aim -To review the data associated with the application of adhesives in digestive surgery procedures. Method -Review of papers available at Medline/Pubmed database using the follow headings: adhesive, gastrointestinal tract, surgical anastomosis, fistula. It was chosen recent articles on the subject which showed adhesives as strategy to reduce morbidity and mortality related to digestive surgery. Conclusion -Tissue adhesives appears to be safe in the clinical setting and are been used with increasing frequency in a variety of surgical field for its unique hemostatic and adhesive abilities, gaining increasing acceptance among surgeons. Studies suggest that surgical adhesive can be useful to reinforce and improve intestinal anastomotic healing, increase anastomotic bursting pressures and tensile strength. The potentially harmful tissue effects of the preparations might compromise the use of these substances. Because of the heterogeneity and lack of high level evidence, new studies have to be performed. ABCDDV/726 INTRODUÇÃOA busca por uma anastomose impermeável tem sido fato constante ...

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Effects of primary suture and fibrin sealant on hemostasis and liver regeneration in an experimental liver injury

Abstract: Out data suggest that fibrin sealant is preferred over primary suture in appropriate cases including liver trauma since it causes less intra-abdominal adhesions while allowing shorter hemostasis time as assessed in experimental liver trauma.

Cited by 17 publications

References 26 publications

Management of Liver Trauma in Minia University Hospital, Egypt

Management of Liver Trauma in Minia University Hospital, Egypt

The effect of fibrin sealant spraying on prolonged air leak after pulmonary resections: a single center experience

Uso de adesivos teciduais em cirurgia digestiva

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