Effects of primary Sjögren's syndrome on hearing and vestibular systems

Ulusoy, Bülent; Limon, Muhammet; Yılmaz, Sema; Keles, Bahar; Aygün, Ahmet Abdurrahman; Körez, Muslu Kazım; Erdur, Ömer

doi:10.1017/s0022215122000391

Cited by 4 publications

(5 citation statements)

References 17 publications

(63 reference statements)

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“…19 22 24 In one study, there was no complaint of vertigo by patients with SjD, although the N1 latency value of the ocular vestibular-evoked myogenic potentials test was significantly longer than normal values, and the posterior semicircular canal and lateral semicircular canal vestibulo-ocular reflex gain values were significantly lower in patients with SjD. 19 The above study suggests the presence of subclinical vestibular dysfunction although the patients did not complaint of overt vertigo. Vertigo is an illusory sensation of movement in the surroundings which arises from asymmetric signals generated in the vestibular system due to impairment or malfunction of the labyrinth, vestibular nerve, or central vestibular pathways in the midbrain or cerebellum.…”

Section: Discussionmentioning

confidence: 87%

“…The presence of these diagnoses were identified by finding their respective ICD codes in the ambulatory visit claims, tinnitus (ICD-9-CM code 388.3 or ICD-10-CM H93.1, H93.11, H93.12, H93.13 or H93. 19), hearing loss (ICD-9-CM 389 or ICD-10-CM H90 or H91), sudden deafness (ICD-9-CM 388.2 or ICD-10-CM H91.2) or vertigo (ICD-9-CM 386.1, 386.10 and 386.19 or ICD-10-CM H81.391, H81.311, H81.312 or H81.313). One previous Epidemiology Epidemiology Epidemiology study has used the same ICD codes to examine the association of Fabry disease with hearing loss, tinnitus and sudden hearing loss.…”

Section: Measures Of Outcomesmentioning

confidence: 99%

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Increased prevalence of hearing loss, tinnitus and sudden deafness among patients with Sjögren’s syndrome

Yang,

Xirasagar,

Cheng

et al. 2024

RMD Open

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BackgroundThis study aimed to provide an updated prevalence of hearing loss, tinnitus, vertigo and sudden deafness on patients with Sjögren’s syndrome and matched comparison patients.MethodsData for this study were retrieved from the Taiwan Longitudinal Health Insurance Database and Taiwan’s registered catastrophic illness dataset. This study included 20 266 patients with Sjögren’s syndrome as the study group and 60 798 propensity score-matched comparison patients as the comparison group. We used multivariable logistic regressions to estimate the ORs and 95% CI for tinnitus, hearing loss, vertigo and sudden deafness among Sjögren’s syndrome patients versus comparison patients.Resultsχ2tests showed there were statistically significant differences between the study group and comparison group in the prevalence of tinnitus (10.1% vs 6.3%, p<0.001), hearing loss (5.6% vs 3.3%, p<0.001), vertigo (4.6% vs 3.2%, p<0.001) and sudden deafness (0.8% vs 0.6%, p<0.001). Multiple logistic regression revealed that patients with Sjögren’s syndrome had a greater tendency to have tinnitus (OR=1.690, 95% CI 1.596–1.788), sudden deafness (OR=1.368, 95% CI 1.137–1.647), hearing loss (OR=1.724, 95% CI 1.598–1.859) and vertigo (OR=1.473, 95% CI 1.360–1.597) relative to comparison patients after adjusting for age, income, geographic location, residential urbanisation level, diabetes, hypertension, hyperlipidaemia and rheumatoid arthritis.ConclusionsWe found higher prevalence of hearing loss, vertigo, tinnitus and sudden deafness among patients with Sjögren’s syndrome relative to comparison patients. Findings may provide guidance to physicians in counselling patients with Sjögren’s syndrome regarding a higher risk of hearing loss, tinnitus, sudden deafness and vertigo.

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Section: Discussionmentioning

confidence: 87%

Section: Measures Of Outcomesmentioning

confidence: 99%

Increased prevalence of hearing loss, tinnitus and sudden deafness among patients with Sjögren’s syndrome

Yang,

Xirasagar,

Cheng

et al. 2024

RMD Open

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“…• Analysis of corneal nerve fibre pattern and corneal nerve plexus density by corneal confocal microscopy has investigated as potential noninvasive tool to characterise SS patients with peripheral nervous system involvement, including patients with small fibre neuropathy (SFN) display a different (46,47). • Early subclinical vestibular involvement has been demonstrated by vestibular-evoked myogenic potentials and video head impulse tests in SS patients (49). • Infection risk, cardiovascular disease and higher risk of haematologic neoplasia, in particular lymphoma, have been confirmed as the most frequent comorbidities in SS (53,54,56).…”

Section: Take Home Messagesmentioning

confidence: 99%

Sjögren's syndrome: one year in review 2023

Longhino,

Chatzis,

Dal Pozzolo

et al. 2023

Clinical and Experimental Rheumatology

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Primary Sjögren's syndrome (pSS) is a systemic autoimmune disorder characterised by the T-cell-mediated hyperactivation of B-cells and cytokine production. The condition may evolve from an asymptomatic, indolent course, with glandular involvement, to extraglandular systemic manifestations up to lymphoma development. On tissue level, the typical feature is the lymphocytic infiltration of the salivary gland by B-, T-and antigen presenting cells, as mirrored by the diagnostic cornerstone role of minor salivary gland (MSG) biopsy. Recently, increasing research focused on the investigation of mechanisms underlying the complex pathogenesis of the disease and highlighted the multifactorial nature of SS consisting of concomitant involvement of environmental, genetic, neuroendocrine and immune factors. In particular, many aspects have been investigated regarding genetic and epigenetics, the role of specific B-and T-cell phenotypes and the investigation of disease-specific biomarkers as predictors of disease development, activity, and lymphomagenesis. Surely, a deeper understanding of these multiple mechanisms may facilitate earlier diagnosis, enable subphenotyping of patients and open novel therapeutic possibilities to address the unmet needs of the disease in the upcoming years.In this review, following the others of this series, we will summarise the most recent literature on pSS pathogenesis and clinical features focusing in particular on new insights into pSS molecular stratification and therapeutic advances in the era of precision medicine.

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“…in this month's issue is the first study to evaluate primary Sjögren's syndrome in terms of vestibular involvement using vestibular-evoked myogenic potentials and video head impulse tests. 4 It shows that primary Sjögren's syndrome is not only a disease that negatively affects the auditory system, but also results in subclinical vestibular involvement. 5…”

mentioning

confidence: 99%

“…A paper by Ulusoy et al in this month's issue is the first study to evaluate primary Sjögren's syndrome in terms of vestibular involvement using vestibular-evoked myogenic potentials and video head impulse tests. 4 It shows that primary Sjögren's syndrome is not only a disease that negatively affects the auditory system, but also results in subclinical vestibular involvement. 5 This year has been a busy year for The Journal, and we look forward to the updated UK national multidisciplinary management guidelines for head and neck cancer, which are due to be published shortly in The Journal.…”

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confidence: 99%