Effects of primary glaucoma on sleep quality and daytime sleepiness of patients residing at an equatorial latitude

Chin, Jacob Yh; Toh, Zhi Hong; Lo, Ying Tai; Wang, Hannah Ty; Poh, Elizabeth Yw; Chua, Chun Hau; Hee, Owen Kim; Lim, Bee Jik; Yong, V. Wee; Laude, Augustinus; Wong, Hon Tym; Yip, Leonard Wei Leon

doi:10.18240/ijo.2020.09.18

Cited by 9 publications

(19 citation statements)

References 43 publications

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“…According to the current study, the glaucoma population had significantly higher poor quality of sleep as compared with non-glaucoma participants. The same result was reported in Glostrup, Denmark, 37 Germany, 20 Southwest Nigeria, 21 Japan, 19 South-East Asian 26 and China. 18 Overall; this study determined that participants with glaucoma were 2.6 times more likely to have poor quality of sleep than participants without glaucoma.…”

Section: Discussionsupporting

confidence: 81%

“…46,47 However; there was no statistically significant difference in poor quality of sleep between visual impairment and normal vision in Southwest Nigeria, 21 in Japan 19 and in Southeast Asia. 26 In contrast to earlier studies, the majority of the glaucoma patients in this study (85.5%) had visual impairment.…”

contrasting

confidence: 97%

“…24 The occurrence of poor quality of sleep with glaucoma could be augmented by older age groups, high intraocular pressure (IOP), advanced stage of glaucoma, type of glaucoma, visual field defects, presence of depression, low family income, high body mass index and low level of educational status. [18][19][20]25,26 The possible mechanism to reduce the occurrence of poor quality of sleep in glaucoma includes provision of appropriate psychiatric care and counseling as well maintenance of relevant medication to treat the disorder. 27 A scientific hypothesis documented in the literature states that glaucomatous damage of the retinal ganglion cells is associated with poor quality of sleep.…”

Section: Introductionmentioning

confidence: 99%

“…45 However; a study in South-East Asia revealed that age did not significantly affect quality of sleep among the glaucoma population. 26 The population with glaucoma who had vision impairment were 3.9 times more likely to have poor sleep than those with normal vision. This relationship might be explained by the scientific evidence that visual impairment reduces daytime light exposure and physical activity, which can diminish melatonin secretion at night.…”

mentioning

confidence: 99%

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Association of Glaucoma with Poor Quality of Sleep in an Ethiopian Glaucoma Population – A Comparative Cross-Sectional Study

Tegegne¹,

Hussen²,

Ayele³

et al. 2022

OPTH

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Background: Glaucoma is a group of ocular disorders characterized by progressive optic nerve damage resulting in irreversible visual field defects. Poor quality of sleep in glaucoma patients could be explained by the reduction of the light input to the circadian system as a result of damage to photosensitive retinal ganglion cells in the retina. Information is limited on the association of poor quality of sleep with glaucoma in general and the Ethiopian glaucoma population in particular. Objective: The study aimed to explore the association between poor quality of sleep and glaucoma at a Tertiary Eye Care Center in Ethiopia. Methods: An institutional-based comparative cross-sectional study was conducted among 200 glaucoma and 201 non-glaucoma participants recruited by systematic random sampling. Each group was administered with a Pittsburgh Sleep Quality Index (PSQI) questionnaire. Stata-14 was employed for data analysis; an independent t-test was used to show the statistical difference in the global mean PSQI score for the two groups. A binary logistic regression model was applied to identify factors associated with poor quality of sleep. Statistical significance was declared at a 95% confidence interval and a p-value of <0.05. Results:The prevalence of poor quality of sleep was 82.5% among the glaucoma population, which statistically differed (p<0.001) from the non-glaucomatous population (55.7%). Poor quality of sleep in glaucoma was associated with older age (adjusted odds ratio (AOR)=4.4, 95% confidence interval (CI): 1.5-5.4), depression (AOR=2.9, 95% CI: 1.1-7.3), visual impairment (AOR=3.9, 95% CI: 1.3-12.3) and severe glaucoma (AOR=2.5, 95% CI: 1.1-5.9). Conclusion and Recommendation:Poor quality of sleep was significantly higher in the glaucoma population compared to their non-glaucoma control. It was associated with older age, depression, visual impairment and advanced glaucoma. Incorporating psychiatric counseling into the existing glaucoma follow-up was recommended.

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Section: Discussionsupporting

confidence: 81%

contrasting

confidence: 97%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Association of Glaucoma with Poor Quality of Sleep in an Ethiopian Glaucoma Population – A Comparative Cross-Sectional Study

Tegegne¹,

Hussen²,

Ayele³

et al. 2022

OPTH

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“…Additionally, there is evidence that patients with glaucoma have greater daytime sleepiness and/or decreased sleep quality compared to age-matched control subjects ( 17 – 19 ). A large cross-sectional study with more than 6,700 patients reported an association between glaucoma and very long sleep duration ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Can Extra Daytime Light Exposure Improve Well-Being and Sleep? A Pilot Study of Patients With Glaucoma

et al. 2021

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Glaucoma damages retinal ganglion cells, including intrinsically photosensitive retinal ganglion cells (ipRGCs). These cells modulate various non-visual physiological and psychological functions which are modulated by light. In patients with glaucoma, we assessed the effect of daily bright light exposure (LE) on several melanopsin-dependent functions, such as the pupil constriction, circadian rest-activity cycles, sleep and subjective well-being including relaxation, alertness and mood. Twenty patients participated in the study (9 women, 11 men, mean age = 67.6 ± 7.5 y). Pupillometry was performed before the LE weeks and repeated on the last day of LE. The post-illumination pupil response (PIPR) was calculated as a proxy for melanopsin-dependent activation. Participants continuously wore an activity monitor and self-assessed sleep quality, well-being and visual comfort for 7 days before and during 4 weeks of daily bright LE (30 min to 10,000 lux polychromatic bright white light). After the LE, there was a significantly greater PIPR and higher subjective sleep quality when compared to the pre-LE week (p < 0.05), but no significant changes in 24-h rhythms or sleep parameters. A greater PIPR was correlated with an increase in circadian amplitude and higher inter-daily stability (derived from rest-activity cycles; p < 0.05). In a small group of patients with glaucoma, scheduled daily bright light exposure could improve subjective sleep quality. These findings highlight the importance to evaluate and maintain non-visual functions at different levels in patients with progressive loss of ipRGCs.

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Subjective and Objective Measurement of Sleep Quality and Activity in Glaucoma

Stoner¹,

Patnaik²,

Ertel³

et al. 2023

Journal of Glaucoma

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Précis: Glaucoma patients exhibit worse indices of sleep function by both objective and subjective metrics compared with controls. Purpose: The purpose of this study is to characterize the sleep parameters and physical activity levels of glaucoma patients compared with controls. Patients and Methods: A total of 102 patients with a diagnosis of glaucoma in at least 1 eye and 31 control subjects were enrolled in the study. Participants completed the Pittsburgh Sleep Quality Index (PSQI) during enrollment and then wore wrist actigraphs for 7 consecutive days to characterize circadian rhythm, sleep quality, and physical activity. The primary outcomes of the study were subjective and objective metrics of sleep quality using the PSQI and actigraphy devices, respectively. The secondary outcome was physical activity, measured by the actigraphy device. Results: From the PSQI survey, glaucoma patients had higher (worse) scores compared with controls for sleep latency, sleep duration, and subjective sleep quality, whereas scores for sleep efficiency were lower (better), suggesting more time spent in bed asleep. By actigraphy, time in bed was significantly higher in glaucoma patients as was time awake after sleep onset. Interdaily stability, quantifying the synchronization to the 24-hour light-dark cycle, was lower in glaucoma patients. There were no other significant differences between glaucoma and control patients with regard to rest-activity rhythms or physical activity metrics. In contrast to the survey data, findings from the actigraphy demonstrated that there were no significant associations between the study group and controls regarding sleep efficiency, onset latency, or total sleep time. Conclusions: In this study, patients with glaucoma demonstrated several subjective and objective differences in sleep function when compared with controls, whereas physical activity metrics were similar.

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Effects of primary glaucoma on sleep quality and daytime sleepiness of patients residing at an equatorial latitude

Cited by 9 publications

References 43 publications

Association of Glaucoma with Poor Quality of Sleep in an Ethiopian Glaucoma Population – A Comparative Cross-Sectional Study

Association of Glaucoma with Poor Quality of Sleep in an Ethiopian Glaucoma Population – A Comparative Cross-Sectional Study

Can Extra Daytime Light Exposure Improve Well-Being and Sleep? A Pilot Study of Patients With Glaucoma

Subjective and Objective Measurement of Sleep Quality and Activity in Glaucoma

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