Effects of Preoperative Radiotherapy for Primary Resectable Rectal Adenocarcinoma on Male Sexual and Urinary Function

Bonnel, C.; Parc, Yann; Pocard, Marc; Dehni, Nidal; Caplin, Scott; Parc, R; Tiret, Emmanuel

doi:10.1007/s10350-004-6332-8

Cited by 76 publications

(59 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite these shortcomings, our data suggest that, in spite of better visualization of the autonomic nerves, the occurrence of neurogenic sexual dysfunction and LUTS after LTME are comparable to the results found in studies after OTME [1,2].…”

Section: Discussionsupporting

confidence: 77%

Male sexual function and lower urinary tract symptoms after laparoscopic total mesorectal excision

Breukink

Driel

Pierie

et al. 2008

Int J Colorectal Dis

View full text Add to dashboard Cite

Background and aims The aim of this study was to investigate sexual function and the presence of lower urinary tract symptoms (LUTS) in male patients with rectal cancer following short-term radiotherapy and laparoscopic total mesorectal excision (LTME) by physical and psychological measurements. Materials and methods Sexual function and LUTS were assessed by the use of questionnaires [International Index of Erectile Function (IIEF), International Prostate Symptom Score]. Sexual function was further assessed by the use of pharmaco duplex ultrasonography of the cavernous arterial blood flow and nocturnal penile tumescence and rigidity monitoring (NPTR). All investigations were performed prior to the start of preoperative radiotherapy and 15 months after surgery. Results Nine patients (mean age 60 years) participated. Erectile function was maintained in 71% and ejaculation function in 89%. Compared with pre-operative scores on the IIEF, a significant deterioration in intercourse satisfaction was seen following radiotherapy and LTME (7.9 vs 10.3, p=0.042), but overall satisfaction remained unchanged (8.0 vs 7.0, p=0.246). NPTR parameters (duration of erectile episodes, duration of tip rigidity ≥60%) decreased following radiotherapy and LTME. Patients reported a deterioration in micturition frequency (2.0 vs 1.0, p=0.034) and quality of life due to urinary symptoms (8.0 vs 1.8, p=0.018). Conclusion Based on these first preliminary findings, data suggest that 15 months after short-term radiotherapy and LTME in men with rectal cancer, objectively assessed sexual dysfunction was considerable, but overall sexual satisfaction had not changed.

show abstract

Section: Discussionsupporting

confidence: 77%

Male sexual function and lower urinary tract symptoms after laparoscopic total mesorectal excision

Breukink

Driel

Pierie

et al. 2008

Int J Colorectal Dis

View full text Add to dashboard Cite

show abstract

“…The rate of LR after ISR varies from 0% to 22.7%, lower than that after APR (10–57%) for mid or low rectal cancer 27, 31, 67. Neoadjuvant CRT affects the down‐sizing of tumor and down‐staging of disease, and is often used as a standard strategy to avoid a positive CRM and LR in rectal cancer patients 68, 69, 70, 71, 72. However, some questions remain as to whether neoadjuvant CRT should be more widely applied for patients who would undergo ISR.…”

Section: Discussionmentioning

confidence: 99%

“…However, some questions remain as to whether neoadjuvant CRT should be more widely applied for patients who would undergo ISR. CRT is associated with higher surgical complications,68, 69 a negative impact on anal function,45, 70 and sexual disorder,71 and has no clear survival benefit 72. In Japan, preoperative neoadjuvant CRT has not been routinely carried out for resectable T1, T2 and T3 tumors regardless of the presence or absence of lymph node metastasis.…”

Section: Discussionmentioning

confidence: 99%

Intersphincteric resection for very low rectal cancer: A review of the updated literature

Shirouzu

Murakami

Akagi

2017

Annals of Gastroent Surgery

View full text Add to dashboard Cite

Intersphincteric resection (ISR) has rapidly increased worldwide including laparoscopic surgery. However, there are some concerns for the definition of ISR, surgical technique, oncological outcome, anal function, and quality of life (QoL). The aim of the present study is to evaluate those issues. A review of this surgical technique was carried out by searching English language literature of the PubMed online database and appropriate articles were identified. With regard to open‐ISR, the morbidity rate ranged from 7.5% to 38.3%, with lower mortality rates. Local recurrence rates varied widely from 0% to 22.7%, with a mean follow‐up duration of 40–94 months. Disease‐free and overall 5‐year survival rates were 68–86% and 76–97%, respectively. Those outcomes were equivalent to laparoscopic‐ISR. Surgical and oncological outcomes of ISR were generally acceptable. However, accurate evaluation of anal function and QoL was difficult because of a lack of standard assessment of various patient‐related factors. The surgical and oncological outcomes after ISR seem to be acceptable. The ISR technique seems to be valid as an alternative to abdominoperineal resection in selected patients with a very low rectal cancer. However, both necessity for ISR and expectations of QoL impairment as a result of functional disorder should be fully discussed with patients before surgery.

show abstract

“…In the series of Bonnel et al [50] sexual function was altered more in those patients who received preoperative pelvic radiotherapy than those who underwent surgery alone. Spontaneous erection, stimulated erection, and rigidity of erection were unchanged between the two groups.…”

Section: Male Sexual Dysfunctionmentioning

confidence: 94%

“…Microscopic changes include fibrosis of the nerve sheath with demylination and fibrous replacement of the nerve fibers. It has been suggested that the fibrosis causes nerve entrapment with secondary demylination and vascular injury [50]. Pelvic radiation can also lead to fibrosis of the seminal vesicles, impairing their normal function.…”

Section: Sexual Dysfunctionmentioning

confidence: 99%

Quality of life after rectal resection and multimodality therapy

Hassan

Cima

2007

Journal of Surgical Oncology

View full text Add to dashboard Cite

Modern management of locally advanced rectal cancer requires a multimodality approach. This includes radical surgery, pelvic radiotherapy, and systemic chemotherapy. It can require a permanent colostomy and result in significant bowel, sexual, and urinary dysfunction. In order to determine the effectiveness of various multimodality regimens it is important to not only assess conventional oncologic outcomes but also the impact on patient's quality of life.

show abstract

Effects of Preoperative Radiotherapy for Primary Resectable Rectal Adenocarcinoma on Male Sexual and Urinary Function

Abstract: Preoperative radiotherapy for primary resectable rectal carcinoma treated by total mesorectal excision with autonomic nerve preservation may impair male sexual function.

Cited by 76 publications

References 24 publications

Male sexual function and lower urinary tract symptoms after laparoscopic total mesorectal excision

Male sexual function and lower urinary tract symptoms after laparoscopic total mesorectal excision

Intersphincteric resection for very low rectal cancer: A review of the updated literature

Quality of life after rectal resection and multimodality therapy

Contact Info

Product

Resources

About