Effects of prenatal stress and exercise on dentate granule cells maturation and spatial memory in adolescent mice

Bustamante, Carlos; Bilbao, Pamela; Contreras, William Mauricio Rojas; Martinez, Mauricio A.; Mendoza, A. Zea; Reyes, Álvaro; Pascual, Rodrigo

doi:10.1016/j.ijdevneu.2010.07.229

Cited by 42 publications

(31 citation statements)

References 50 publications

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“…Prenatally stressed rats show depressive-like behaviors including increased immobility in the Porsolt swim test (Alonso et al, 1991;Frye and Wawrzycki, 2003) and increased anxiety in the elevated plus maze (Fride and Weinstock, 1988). Spatial learning deficits are also observed in adolescent mice (Bustamante et al, 2010) and adult rats (Hosseini-Sharifabad and Hadinedoushan, 2007;Wu et al, 2007) of prenatally restrained mothers.…”

Section: Effects Of Maternal Stressmentioning

confidence: 99%

Maternal influences on epigenetic programming of the developing hypothalamic‐pituitary‐adrenal axis

Grace

Kim

Rogers

2011

Birth Defects Research

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Parental and environmental factors during the prenatal and postnatal periods permanently affect the physiology and metabolism of offspring, potentially increasing disease risk later in life. Underlying mechanisms are being elucidated, and effects on a number of organs and metabolic pathways are likely involved. In this review, we consider effects on the developing hypothalamic-pituitary-adrenal (HPA) axis, which may represent a common pathway for developmental programming. The focus is on prenatal and early postnatal development, during which the HPA axis may be programmed in a manner that affects health for a lifetime. Programming of the HPA axis involves, at least in part, epigenetic remodeling of chromatin, leading to alterations in the expression of genes in many organs and tissues involved in HPA activation and response, including the hippocampus and peripheral tissues.

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Section: Effects Of Maternal Stressmentioning

confidence: 99%

Maternal influences on epigenetic programming of the developing hypothalamic‐pituitary‐adrenal axis

Grace

Kim

Rogers

2011

Birth Defects Research

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“…Given the negative effects of loud noise levels on release of stress hormones and cognitive performance [17, 19], we hypothesized that gestational noise exposure strongly activates the hypothalamic–pituitary–adrenal (HPA) axis and adversely affects spatial learning and memory function in the postpartum dams as large as the physical stressors [5, 26], i.e., restraint combined with placement on an exposed elevated platform in the present study.…”

Section: Introductionmentioning

confidence: 99%

Corticosterone response to gestational stress and postpartum memory function in mice

et al. 2017

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Maternal stress is a common adversity during pregnancy. Gestational corticosterone alternations are thought to contribute to the etiology of postpartum behavioral disturbances. However, the impact of stress during pregnancy, in particular noise exposure, on gestational corticosterone fluctuations and spatial cognition in postpartum mice has not been fully understood yet. We hypothesized that noise exposure during pregnancy negatively affects gestational corticosterone levels and postpartum memory function in the dams similar to the physical stressors. Pregnant C57BL/6 mice were randomly assigned to either one of two stress conditions or a control condition. The noise stress (NS) was induced by presenting a loud intermittent 3000 Hz frequency on gestational days (GDs) 12, 14, and 16 for 24 hours, whereas the physical stress (PS) consisted of restraint and exposure to an elevated platform on GDs 12–16. Plasma corticosterone level was collected on GDs 11 and 17, and Morris water task (MWT) was carried out 30 days after parturition. Compared to the control group, the level of corticosterone in the stressed groups was significantly increased on GD17 relative to GD11. Significantly longer swim time and lower swim speed were observed in both stressed groups relative to the control group. Probe time was significantly shorter in the NS group than the other groups. The delta corticosterone level was significantly correlated with the swim time as well as the probe time in the three groups. Given the results, the adverse effects of gestational noise exposure on the hypothalamic pituitary-adrenal (HPA) axis activation and postpartum spatial learning and memory function were as large as/ or a bit stronger than the physical stresses. The findings suggest the significance of conservation against loud noise exposure in daily living, as well as need to further notice to the different aspects of gestational stress in mothers’ behavior like offspring.

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“…Clinical studies demonstrate that exposure of pregnant mothers to stressful conditions increases the susceptibility of their offspring to mental disorders, such as depression, schizophrenia, and cognitive deficits [2]. Animal studies show that prenatal stress causes alterations of both the hypothalamic-pituitary adrenocortical axis and the brain neurotransmitter systems and also impairs hippocampal-dependent spatial learning and memory abilities in offspring [3,4]. Pregnant rodents that have suffered restraint stress represent a valid model of stress with neurobiological and behavioral consequences [5,6].…”

mentioning

confidence: 99%

AMPK activation prevents prenatal stress-induced cognitive impairment: Modulation of mitochondrial content and oxidative stress

Cao

Zheng

et al. 2014

Free Radical Biology and Medicine

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Effects of prenatal stress and exercise on dentate granule cells maturation and spatial memory in adolescent mice

Cited by 42 publications

References 50 publications

Maternal influences on epigenetic programming of the developing hypothalamic‐pituitary‐adrenal axis

Maternal influences on epigenetic programming of the developing hypothalamic‐pituitary‐adrenal axis

Corticosterone response to gestational stress and postpartum memory function in mice

AMPK activation prevents prenatal stress-induced cognitive impairment: Modulation of mitochondrial content and oxidative stress

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