Effects of prenatal propofol exposure on postnatal development in rats

Li, Jing; Xiong, Ming; Alhashem, Hussain M.; Zhang, Yong; Tilak, Vasanti; Patel, Anuradha; Siegel, Allan; Ye, Jiang Hong; Bekker, Alex

doi:10.1016/j.ntt.2014.03.006

Cited by 23 publications

(13 citation statements)

References 47 publications

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“…Although other studies have reported neurotoxic potential exposure related to Propofol (Yu et al, 2013;Creeley et al, 2013;Yang et al, 2014;Li et al, 2014), according to the results of this study, the anesthetic does not seem to modify the reflection development of the puppies, because there were no differences between the response time for animal control or treated groups.…”

Section: Discussioncontrasting

confidence: 71%

“…Although not recommended, propofol is considered safe for pregnant women and is widely used in non-obstetric surgeries and procedures during pregnancy (Ooi & Thomson, 2015). Recent studies in rats have concluded that exposure to propofol during development leads to retardation of physical and neurological reflex, suggesting nervous system injury (Li et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

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<b>Damage caused by exposure to propofol during gestation of mice

Sensiate

Bispo

Guarido

et al. 2017

Acta Sci. Health Sci.

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ABSTRACT. Literature shows that surgical procedure could be necessary at any stage of pregnancy and can cause adverse effects on the mother and fetus. One of the most used anesthetics in surgical centers is propofol however; the safety during pregnancy has not been completely established. The objective of this study was to investigate the possible toxic and teratogenic effects on the intrauterine and post-natal development of mice exposed to the dose of 15 mg kg -1 propofol on the caudal vein fifth, tenth and fifteenth day of gestation. A significant reduction in weight gain was observed in female mice who received a 15 mg kg -1 dose of propofol on the fifth gestational day. A higher rate of embryonic loss post implantation and resorption was also observed in this group. In regards to physical development, the anesthetic increased significantly the offspring weight gain, the time in which pinna detachment occurred, and the anogenital distance of pups whose females received propofol on the fifteenth day of gestation. Based on these results, we concluded that administration of propofol in the beginning stages of gestation increases the number of abortions and promotes alterations in the physical development of pups whose mothers were anesthetized in the final stages of gestation.Keywords: propofol, gestation, non-obstetric surgery, embryonic development.Danos causados pela exposição ao propofol durante a gestação em camundongos RESUMO. A literatura mostra que o procedimento cirúrgico pode ser necessário em qualquer fase da gravidez podendo causar efeitos adversos sobre a mãe e o feto. Um dos anestésicos mais utilizados nos centros cirúrgicos é o propofol, no entanto, a sua segurança durante a gravidez não foi completamente estabelecida. O objetivo deste estudo foi investigar os possíveis efeitos tóxicos e teratogênicos no desenvolvimento intrauterino e pós-natal de camundongos expostos à dose de 15 mg kg -1 de propofol no quinto, décimo e décimo quinto dia de gestação. Observou-se uma redução significativa no ganho de peso em camundongos fêmeas que receberam uma dose de 15 mg kg -1 de propofol no quinto dia de gestação. Uma taxa maior de perda embrionária pós-implantação e reabsorção também foi observada neste grupo. Em relação ao desenvolvimento físico, o anestésico alterou significativamente o ganho de peso da prole, o tempo em que ocorreu o desprendimento da orelha e a distância anogenital dos filhotes cujas fêmeas receberam propofol no décimo quinto dia de gestação. Com base nesses resultados, concluiu-se que a administração de propofol nos estágios iniciais da gestação aumenta o número de abortos e promove alterações no desenvolvimento físico de filhotes cujas mães foram anestesiadas nos estádios finais da gestação.Palavras-chave: propofol, gestação, cirurgia não-obstétrica, desenvolvimento embrionário.

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Section: Discussioncontrasting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

<b>Damage caused by exposure to propofol during gestation of mice

Sensiate

Bispo

Guarido

et al. 2017

Acta Sci. Health Sci.

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“…The learning capability of the propofoltreated group was persistently impaired, as was assessed in several experimental tests [15]. Li and colleagues [16] extended these results to a slower maturation of eyes and other neurological reflexes. Propofol was also found to induce apoptosis of neurons and oligodendrocytes in primate brains exposed in utero [17].…”

Section: Neurotoxicitymentioning

confidence: 93%

Nonobstetric anesthesia during pregnancy

Heesen

Klimek

2016

Current Opinion in Anaesthesiology

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“…In the last few years, warning have been raised secondary to animal studies showing an accelerated neuronal apoptosis associated with abnormal behaviour in immature rodents exposed to anaesthetic agents, such as propofol [41,42], sevoflurane [43] or isoflurane [44].…”

Section: Impact On Synaptogenesismentioning

confidence: 99%

Sedation and anaesthesia for non-obstetric surgery

Bonnet

2016

Anaesthesia Critical Care & Pain Medicine

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Effects of prenatal propofol exposure on postnatal development in rats

Cited by 23 publications

References 47 publications

<b>Damage caused by exposure to propofol during gestation of mice

<b>Damage caused by exposure to propofol during gestation of mice

Nonobstetric anesthesia during pregnancy

Sedation and anaesthesia for non-obstetric surgery

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