Effects of prenatal irradiation with accelerated heavy-ion beams on postnatal development in rats: III. Testicular development and breeding activity

Wang, B.; Murakami, Masahirô; Eguchi-Kasai, Kiyomi; Nojima, Kumie; Shang, Yi; Tanaka, Kaoru; Watanabe, Kentaro; Fujita, Kazuko; Moreno, Stephanie; Coffigny, Hervé; Hayata, Isamu

doi:10.1016/j.asr.2007.03.095

Cited by 4 publications

(5 citation statements)

References 42 publications

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“…Wang et al have been reported that the heavy ions are effective at inducing deletions via DNA DSBs but less effective than X-and c irradiations at producing oxidative DNA damage by free radicals (Wang et al, 2007). In this study, no statistical differences were observed in 0.05 or 0.1 Gy when compared to the control group, while the carbon ion irradiation above 0.5 Gy could produce extreme increases in DNA DSB formation at 12 h and 21 d. Our previous data show that 0.05 Gy of carbon ions significantly increased PARP-1 activity and PARP-1 protein expression, and PARP-1 function were inhibited in 2 Gy of carbon ion irradiation group (Zhang et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Low-dose carbon ion irradiation effects on DNA damage and oxidative stress in the mouse testis

Yang

Long

Zhang

et al. 2011

Advances in Space Research

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Section: Discussionmentioning

confidence: 99%

Low-dose carbon ion irradiation effects on DNA damage and oxidative stress in the mouse testis

Yang

Long

Zhang

et al. 2011

Advances in Space Research

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“… 27 Wang et al found that CIR exposure induced spermatogenic cell apoptosis. 28 Here, we focused on the apoptosis pathway to validate the roles of differentially expressed miRNAs. Deep sequencing and qRT-PCR validated that the expression levels of identified miRNAs between irradiated mice testis and controls were largely consistent with sequencing analysis.…”

Section: Discussionmentioning

confidence: 99%

Comparative Profiling of MicroRNAs Reveals the Underlying Toxicological Mechanism in Mice Testis Following Carbon Ion Radiation

Zhang

et al. 2018

Dose-Response

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This study investigated the toxicity of heavy ion radiation to mice testis by microRNA (miRNA) sequencing and bioinformatics analyses. Testicular indices and histology were measured following enterocoelia irradiation with a 2 Gy carbon ion beam, with the testes exhibiting the most serious injuries at 4 weeks after carbon ion radiation (CIR) exposure. Illumina sequencing technology was used to sequence small RNA libraries of the control and irradiated groups at 4 weeks after CIR. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses implicated differential miRNAs in the regulation of target genes involved in metabolism, development, and reproduction. Here, 8 miRNAs, including miR-34c-5p, miR-138, and 6 let-7 miRNA family members previously reported in testis after radiation, were analyzed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) to validate miRNA sequencing data. The differentially expressed miRNAs described here provided a novel perspective for the role of miRNAs in testis toxicity following CIR.

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“…For this purpose, the tracks of 12 C and 56 Fe ions are simulated by using the beam parameters of several real experiments. In the present work, beam entrance parameters listed in Table 2 are taken from or calculated on the basis of experimental data produced at the Nuclotron of Joint Institute for Nuclear Research (Dubna, Russia) (Matveeva et al, 2013), Heavy Ion Medical Accelerator (HIMAC) of National Institute of Radiological Science (Chiba, Japan) (Imaoka et al, 2007;Wang et al, 2007), and Alternating Gradient Synchrotron (AGS) of Brookhaven National Laboratory (Long Island, New York, USA) (Huang, Smith, Cummings, Kendall, & Obenaus, 2009;Sanchez, Nelson, & Green, 2010;Shukitt-Hale, Casadesus, Cantuti-Castelvetri, Rabin, & Joseph, 2003). The particle tracks produced by the Geant4 Toolkit are oriented parallel with Z axis, as it is shown in Fig.…”

Section: Ion Beam Parametersmentioning

confidence: 99%

Estimation of the spatial energy deposition in CA1 pyramidal neurons under exposure to 12C and 56Fe ion beams

Batmunkh

Belov

Bayarchimeg

et al. 2015

Journal of Radiation Research and Applied Sciences

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a b s t r a c tThe exposure to heavy charged particles represents a significant risk to the central nervous system. In experiments with rodents, the irradiation with heavy ions induces a prolonged deficit in hippocampus-dependent learning and memory. The exact nature of these violations remains mostly unclear. In this regard, the estimation of radiation effects at the level of single neurons is of our special interest. The present study demonstrates the results of comparative calculations that are performed to clarify the early physical events in single neurons under the exposure to accelerated 12 C and 56 Fe ions with different parameters. Using the Geant4-based Monte Carlo simulations, the radiation effects are considered in terms of energy and dose deposition. The spatial patterns of energy and dose depositions within a single neural cell are produced. As additional characteristics, the spectra of the specific energy and energy imparted are estimated. Our results show that the cell morphology is an important factor determining the accumulation of radiation dose in neurons under the exposure to heavy ions. The data obtained suggest a possibility of radiation damage to synapses that are considered to play an important role in radiationinduced violations of hippocampus-dependent learning and memory.

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Effects of prenatal irradiation with accelerated heavy-ion beams on postnatal development in rats: III. Testicular development and breeding activity

Cited by 4 publications

References 42 publications

Low-dose carbon ion irradiation effects on DNA damage and oxidative stress in the mouse testis

Low-dose carbon ion irradiation effects on DNA damage and oxidative stress in the mouse testis

Comparative Profiling of MicroRNAs Reveals the Underlying Toxicological Mechanism in Mice Testis Following Carbon Ion Radiation

Estimation of the spatial energy deposition in CA1 pyramidal neurons under exposure to 12C and 56Fe ion beams

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