Effects of prenatal exposures to air sulfur dioxide/nitrogen dioxide on toddler neurodevelopment and effect modification by ambient temperature

Yu, Ting; Zhou, Linzhu; Xu, Jian; Kan, Haidong; Chen, Renjie; Chen, Shu-Wen; Hua, Hui; Liu, Zhiwei; Yan, Chen‐Hua

doi:10.1016/j.ecoenv.2021.113118

Cited by 7 publications

(3 citation statements)

References 50 publications

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“…Notably, prenatal PM 2.5 concentration in this cohort is 1.7 times the concentration in our study population (14.2 vs 8.3 μg/m 3 ). One study 36 assessing prenatal NO 2 exposure and gross motor and fine motor scores among 225 mother–full term birth pairs in Shanghai, China, did not find associations over the whole gestational period, which was consistent with the null result in our study. However, they suggested that weekly average NO 2 concentrations had adverse associations with gross motor scores during gestational weeks 33 to 36, and with fine motor scores in weeks 26 to 36.…”

Section: Discussionsupporting

confidence: 92%

“…Our results were consistent with the literature investigating the association between prenatal PM 2.5 and other neurodevelopmental disorders such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and neurocognitive functions. 33 , 35 , 36 Specifically, 1 study 35 among a US Southern California cohort found ambient PM 2.5 exposure in the first 2 trimesters was associated with increased risks of ASD from 2001 to 2014. Notably, prenatal PM 2.5 concentration in this cohort is 1.7 times the concentration in our study population (14.2 vs 8.3 μg/m 3 ).…”

Section: Discussionmentioning

confidence: 99%

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Prenatal Exposure to Ambient Air Pollution and Cerebral Palsy

Zhang,

Hu,

Talarico

et al. 2024

JAMA Netw Open

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ImportanceAir pollution is associated with structural brain changes, disruption of neurogenesis, and neurodevelopmental disorders. The association between prenatal exposure to ambient air pollution and risk of cerebral palsy (CP), which is the most common motor disability in childhood, has not been thoroughly investigated.ObjectiveTo evaluate the associations between prenatal residential exposure to ambient air pollution and risk of CP among children born at term gestation in a population cohort in Ontario, Canada.Design, Setting, and ParticipantsPopulation-based cohort study in Ontario, Canada using linked, province-wide health administrative databases. Participants were singleton full term births (≥37 gestational weeks) born in Ontario hospitals between April 1, 2002, and March 31, 2017. Data were analyzed from January to December 2022.ExposuresWeekly average concentrations of ambient fine particulate matter with a diameter 2.5 μm (PM2.5) or smaller, nitrogen dioxide (NO2), and ozone (O3) during pregnancy assigned by maternal residence reported at delivery from satellite-based estimates and ground-level monitoring data.Main outcome and measuresCP cases were ascertained by a single inpatient hospitalization diagnosis or at least 2 outpatient diagnoses for children from birth to age 18 years.ResultsThe present study included 1 587 935 mother-child pairs who reached term gestation, among whom 3170 (0.2%) children were diagnosed with CP. The study population had a mean (SD) maternal age of 30.1 (5.6) years and 811 745 infants (51.1%) were male. A per IQR increase (2.7 μg/m3) in prenatal ambient PM2.5 concentration was associated with a cumulative hazard ratio (CHR) of 1.12 (95% CI, 1.03-1.21) for CP. The CHR in male infants (1.14; 95% CI, 1.02-1.26) was higher compared with the CHR in female infants (1.08; 95% CI, 0.96-1.22). No specific window of susceptibility was found for prenatal PM2.5 exposure and CP in the study population. No associations or windows of susceptibility were found for prenatal NO2 or O3 exposure and CP risk.Conclusions and relevanceIn this large cohort study of singleton full term births in Canada, prenatal ambient PM2.5 exposure was associated with an increased risk of CP in offspring. Further studies are needed to explore this association and its potential biological pathways, which could advance the identification of environmental risk factors of CP in early life.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Prenatal Exposure to Ambient Air Pollution and Cerebral Palsy

Zhang,

Hu,

Talarico

et al. 2024

JAMA Netw Open

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“…In that study, the average exposure level of SO 2 during pregnancy was approximately 5.8 ppb during the observation period, which is similar to the result of our study (an average of 5 ppb), but the relationship between prenatal SO 2 exposure and the risk of ASD showed a different result. Other studies have reported that prenatal SO 2 exposure is associated with poor or impaired neurodevelopment in early childhood [ 44 , 45 ]. It is known that SO 2 may lead to neurotoxicity by inducing oxidative stress, DNA damage, and apoptosis, as well as DNA methylation [ 46 , 47 , 48 , 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Maternal Exposure to Air Pollutants and Heavy Metals during Pregnancy on the Risk of Neurological Disorders Using the National Health Insurance Claims Data of South Korea

et al. 2023

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The objective of this study was to evaluate the effects of high levels of maternal exposure to ambient air pollution and heavy metals on risks of autism spectrum disorder (ASD) and epilepsy using the National Health Insurance claims data of South Korea. The data of mothers and their newborns from 2016 to 2018 provided by the National Health Insurance Service were used (n = 843,134). Data on exposure to ambient air pollutants (PM2.5, CO, SO2, NO2, and O3) and heavy metals (Pb, Cd, Cr, Cu, Mn, Fe, Ni, and As) during pregnancy were matched based on the mother’s National Health Insurance registration area. SO2 (OR: 2.723, 95% CI: 1.971–3.761) and Pb (OR: 1.063, 95% CI: 1.019–1.11) were more closely associated with the incidence of ASD when infants were exposed to them in the third trimester of pregnancy. Pb (OR: 1.109, 95% CI: 1.043–1.179) in the first trimester of pregnancy and Cd (OR: 2.193, 95% CI: 1.074–4.477) in the third trimester of pregnancy were associated with the incidence of epilepsy. Thus, exposure to SO2, NO2, and Pb during pregnancy could affect the development of a neurologic disorder based on the timing of exposure, suggesting a relationship with fetal development. However, further research is needed.

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Effects of Maternal Environmental Exposure on Early Life Growth and Development

Wang

Tian

2023

In Utero Pediatrics

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Effects of prenatal exposures to air sulfur dioxide/nitrogen dioxide on toddler neurodevelopment and effect modification by ambient temperature

Cited by 7 publications

References 50 publications

Prenatal Exposure to Ambient Air Pollution and Cerebral Palsy

Prenatal Exposure to Ambient Air Pollution and Cerebral Palsy

The Effect of Maternal Exposure to Air Pollutants and Heavy Metals during Pregnancy on the Risk of Neurological Disorders Using the National Health Insurance Claims Data of South Korea

Effects of Maternal Environmental Exposure on Early Life Growth and Development

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