Effects of prenatal exposure to air particulate matter on the risk of preterm birth and roles of maternal and cord blood LINE-1 methylation: A birth cohort study in Guangzhou, China

Liu, Xin; Ye, Yufeng; Chen, Yi; Li, Xiaona; Feng, Baixiang; Cao, Ganxiang; Xiao, Jianpeng; Zeng, Weilin; Li, Xing; Sun, Jiufeng; Dan, Ning; Yang, Yi; Yao, Zhenjiang; Lee, Hyewon; Wang, Qiong; Zhang, Yonghui; Ma, Wenjun; Du, Qingfeng; Zhang, Bo; Liu, Tao

doi:10.1016/j.envint.2019.105177

Cited by 54 publications

(45 citation statements)

References 61 publications

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“…All the participants met the inclusion criteria: (1) gestational weeks from 1 to 13; (2) aged 18-50 years; and (3) no comorbidity with the following diseases: hyperthyroidism, heart disease, chronic kidney disease, tuberculosis, and psychiatric disease. Detailed information has been presented elsewhere (30)(31)(32)(33)(34)(35). In this study, we recruited women with singleton pregnancies and without occupational exposure to Tl as study participants.…”

Section: Study Populationmentioning

confidence: 99%

The Mediating Role of Placental Weight Change in the Association Between Prenatal Exposure to Thallium and Birth Weight: A Prospective Birth Cohort Study

Zhou

Sun

Wang

et al. 2021

Front. Public Health

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Background: Previous studies have demonstrated the embryotoxicity and fetotoxicity of thallium (Tl). However, the effects of prenatal exposure to Tl on birth weight and placental weight and the mediating role of placental weight in the association of Tl with birth weight remain unclear.Methods: We recruited 2,748 participants from the ongoing Prenatal Environment and Offspring Health Cohort (PEOH Cohort) study, which was initiated in 2016 in Guangzhou, China. The Tl concentrations in maternal urine samples collected during the first and third trimester were determined by inductively coupled plasma mass spectrometry. Birth weight and placental weight were extracted from maternal medical records.Results: Pregnant women exposed to the highest tertile of Tl in the first trimester (β = −42.7 g, 95% CI: −82.3, −3.1 g) and third trimester (β = −50.6 g, 95% CI: −99.0, −2.3 g) had babies with lower birth weights than those exposed to the lowest tertile. We also found significant negative associations of exposure to Tl concentrations in the first and third trimester with placental weight. Mediation analyses showed that 50.3% (95% CI: 15.9, 79.2%) and 33.5% (95% CI: 1.3, 80.3%) of the effects of Tl exposure in the first and third trimester on birth weight were mediated by decreased placental weight.Conclusion: Our results suggest that prenatal exposure to Tl is negatively associated with birth weight and that this association may be mediated by decreased placental weight.

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Section: Study Populationmentioning

confidence: 99%

The Mediating Role of Placental Weight Change in the Association Between Prenatal Exposure to Thallium and Birth Weight: A Prospective Birth Cohort Study

Zhou

Sun

Wang

et al. 2021

Front. Public Health

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“…DNA methylation signatures of prenatal smoking were even evident in the peripheral blood of offspring collected during early childhood, adolescence, and adulthood, suggesting that prenatal exposures can have persistent effects on one's epigenetics [75,76]. Maternal exposure to air pollution was also found to be associated with global and locus-specific changes in DNA methylation in cord blood and the placenta [77,78]. Dutch famine studies have shown that women whose mothers were exposed to famine while pregnant with them had higher body mass index (BMI) and triglycerides (TG) levels compared to women who were not exposed to famine in utero [79,80].…”

Section: Towards a Better Understanding Of How Exposures Affect Breasmentioning

confidence: 99%

Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention

Park

2020

IJERPH

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Environmental and lifestyle factors are believed to account for >80% of breast cancers; however, it is not well understood how and when these factors affect risk and which exposed individuals will actually develop the disease. While alcohol consumption, obesity, and hormone therapy are some known risk factors for breast cancer, other exposures associated with breast cancer risk have not yet been identified or well characterized. In this paper, it is proposed that the identification of blood epigenetic markers for personal, in utero, and ancestral environmental exposures can help researchers better understand known and potential relationships between exposures and breast cancer risk and may enable personalized prevention strategies.

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“…A recent study of prenatal exposure to PM10, PM2.5, and PM1 in China found that the risk of preterm birth was positively associated with both PM2.5 and PM1 from 12 to 20 weeks gestation, and that cord blood long interspersed nucleotide element 1 ( LINE-1 ) methylation was negatively correlated with all PMs [ 27 ]. Decreased LINE-1 methylation may also have a role in triggering inflammatory responses, a potential mechanism involved in preterm birth [ 27 ]. Another Chinese air pollution study showed that prenatal exposure to PM10 was associated with DNAm of the superoxide dismutase 2 ( SOD2 ) promoter in both maternal and cord blood [ 58 ].…”

Section: Dnam As a Potential Epigenetic Mechanism Linking Smoke Exposure Or Prenatal Stress To Childhood Respiratory Health Outcomesmentioning

confidence: 99%

“…There is a large body of literature examining adverse health effects in children following prenatal traffic-related air pollution exposure, including adverse perinatal outcomes [ 26 ] such as preterm birth [ 27 ], alterations in lung function at 5 weeks [ 1 ] and 6 years of age [ 28 ], and increased risk of asthma development [ 29 ]. Studies of air pollution exposure during pregnancy demonstrating adverse perinatal outcomes indicate that the fetus is highly susceptible to various environmental pollutants via in utero exposure [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Exposure to Stress and Air Pollution from Bushfires during Pregnancy: Could Epigenetic Changes Explain Effects on the Offspring?

Murphy

Karmaus

Mattes

et al. 2021

IJERPH

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Due to climate change, bushfires are becoming a more frequent and more severe phenomenon which contributes to poor health effects associated with air pollution. In pregnancy, environmental exposures can have lifelong consequences for the fetus, but little is known about these consequences in the context of bushfire smoke exposure. In this review we summarise the current knowledge in this area, and propose a potential mechanism linking bushfire smoke exposure in utero to poor perinatal and respiratory outcomes in the offspring. Bushfire smoke exposure is associated with poor pregnancy outcomes including reduced birth weight and an increased risk of prematurity. Some publications have outlined the adverse health effects on young children, particularly in relation to emergency department presentations and hospital admissions for respiratory problems, but there are no studies in children who were exposed to bushfire smoke in utero. Prenatal stress is likely to occur as a result of catastrophic bushfire events, and stress is known to be associated with poor perinatal and respiratory outcomes. Changes to DNA methylation are potential epigenetic mechanisms linking both smoke particulate exposure and prenatal stress to poor childhood respiratory health outcomes. More research is needed in large pregnancy cohorts exposed to bushfire events to explore this further, and to design appropriate mitigation interventions, in this area of global public health importance.

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Effects of prenatal exposure to air particulate matter on the risk of preterm birth and roles of maternal and cord blood LINE-1 methylation: A birth cohort study in Guangzhou, China

Cited by 54 publications

References 61 publications

The Mediating Role of Placental Weight Change in the Association Between Prenatal Exposure to Thallium and Birth Weight: A Prospective Birth Cohort Study

The Mediating Role of Placental Weight Change in the Association Between Prenatal Exposure to Thallium and Birth Weight: A Prospective Birth Cohort Study

Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention

Exposure to Stress and Air Pollution from Bushfires during Pregnancy: Could Epigenetic Changes Explain Effects on the Offspring?

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