Effects of prenatal exposure to morphine on the development of sexual behavior in rats

Vathy, Ilona; Etgen, Anne M.; Barfield, Ronald J.

doi:10.1016/0091-3057(85)90382-x

Cited by 99 publications

(59 citation statements)

References 15 publications

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“…not have a profound effect on males (Vathy et al, 1985). Adult sexual behavior in female rats is both defeminized and masculinized (Vathy, 1999;Gagin et al, 1997b).…”

Section: Animal Studiesmentioning

confidence: 97%

“…There is gender dimorphism in the rodent brain (Vathy, 1995), as prenatal morphine exposure reduces female sexual behavior but does Vathy et al (1983Vathy et al ( , 1985Vathy et al ( , 1999, Gagin et al (1997b) The different studies used different treatment protocols. It is obvious, that many alterations can be found after perinatal opioid exposure, however, most of the changes are mild and cannot be detected in both sexes.…”

Section: Animal Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Behavioral effects of perinatal opioid exposure

2014

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“…not have a profound effect on males (Vathy et al, 1985). Adult sexual behavior in female rats is both defeminized and masculinized (Vathy, 1999;Gagin et al, 1997b).…”

Section: Animal Studiesmentioning

confidence: 97%

Section: Animal Studiesmentioning

confidence: 99%

Behavioral effects of perinatal opioid exposure

2014

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“…On PND1, pups were sexed and weighed. The injection paradigm did not alter the number of pups per litter and the body weight of the offspring as described in previous studies (Vathy et al, 1985;Velisek et al, 2000;Riley and Vathy, 2006). On PND 21, pups were weaned and housed in groups with free access to food and water.…”

Section: Postnatal Treatmentmentioning

confidence: 99%

“…Pregnant rats were randomly injected with morphine (morphine sulfate, 10 mg/ml, obtained from the Anhui Food & Drug Administration, China) or saline twice daily at 09:00 and 21:00 h on gestation days 11-18. The dose of the first three morphine injections was 5 mg/kg and the dose for all subsequent injections was 10 mg/kg (Vathy et al, 1985). All injections were administered subcutaneously (s.c.).…”

Section: Prenatal Treatmentmentioning

confidence: 99%

Impaired in vivo synaptic plasticity in dentate gyrus and spatial memory in juvenile rats induced by prenatal morphine exposure

et al. 2008

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ABSTRACT:Prenatal morphine exposure induces neurobiological changes, including deficits in learning and memory, in juvenile rat offspring. However the effects of this exposure on hippocampal plasticity, which is critical for learning and memory processes, are not well understood. The present study investigates the alterations of spatial memory and in vivo hippocampal synaptic plasticity in juvenile rats prenatally exposed to morphine. On gestation days 11-18, pregnant rats were randomly chosen to be injected twice daily with morphine or saline. Each juvenile offspring (postnatal day 22-31) performed one two-trial Y-maze task to evaluate spatial memory. Afterwards, the in vivo field excitatory postsynaptic potential (fEPSP) and population spike (PS) were recorded in the perforant path dentate gyrus (DG) pathway in the hippocampus. Prenatal morphine exposure reduced depotentiation (DP), but not longterm potentiation (LTP), of the EPSP slope. However, both LTP and DP of the EPSP slope were depressed in prenatal morphine-exposed juvenile offspring. The morphine group also showed poorer performance for the Y-maze task than the control group. Depressed PS LTP, but not EPSP LTP, in the morphine group suggested that prenatal morphine exposure changed GABAergic inhibition, which mediates EPSP-spike potentiation. Then a loss of GABA-containing neurons in the DG area of the morphine group was observed using immunohistochemistry. Taken together, our results suggest that prenatal morphine exposure impairs the juvenile offspring's dentate synaptic plasticity and spatial memory, and that decreased GABAergic inhibition may play a role in these effects. These findings might contribute to an explanation for the cognitive deficits in children whose mothers abuse opiates during pregnancy. V V C 2008 WileyLiss, Inc.

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“…Morphine sulfate was obtained from the National Institute on Drug Abuse (Research Technology Branch, Rockville, Md., USA), and dissolved in 0.9% saline to a final injection volume of 0.1 ml. The dose of the first three morphine injections was 5 mg/kg, and the dose of all subsequent morphine injections was 10 mg/kg [9]. …”

Section: Methodsmentioning

confidence: 99%

Hypothalamo-Pituitary-Adrenal Axis-Regulated Stress Response and Negative Feedback Sensitivity Is Altered by Prenatal Morphine Exposure in Adult Female Rats

et al. 2004

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It has been shown that adult female rats react to stressors more intensely than adult male rats. Our previous work demonstrated that the adrenocorticotropic hormone (ACTH) but not corticosterone (CORT) response to stress is altered by prenatal morphine exposure in adult male rats. Response of the hypothalamo-pituitary-adrenal (HPA) axis to stress is known to be sex specific and dependent on the hormonal fluctuation of the estrous cycle. Therefore, the present study examined the effect of prenatal morphine exposure on the levels of ACTH and CORT before and after restraint stress in adult female rats. Experiment 1 tested ACTH and CORT plasma levels before and after restraint stress in prenatally morphine- and saline-exposed, adult diestrus and proestrus female rats. Prenatal morphine exposure suppressed the restraint stress-induced ACTH levels in both diestrus and proestrus females, but did not have any effects on the basal or stress-induced CORT levels. Experiment 2 examined the sensitivity of negative feedback using the dexamethasone (DEX) (0.001, 0.01, 0.1 and 1.0 mg/kg) suppression test in adult, prenatally morphine- and saline-exposed female rats. In saline-exposed, proestrus but not diestrus females, all doses of DEX were effective in suppressing the restraint stress-induced increase in CORT levels. In both diestrus and proestrus, morphine-exposed females, only the two highest doses of DEX (0.1 and 1.0 mg/kg) were successfully suppressing the stress-induced CORT levels. The stress-induced increase in the ACTH level was suppressed only by the highest dose of DEX (1.0 mg/kg) in both saline- and morphine-exposed, diestrus and proestrus females. Thus, the present study demonstrates that prenatal morphine exposure alters the HPA axis-regulated stress response and the sensitivity of negative feedback that are affected by the fluctuation of ovarian hormones.

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Effects of prenatal exposure to morphine on the development of sexual behavior in rats

Cited by 99 publications

References 15 publications

Behavioral effects of perinatal opioid exposure

Behavioral effects of perinatal opioid exposure

Impaired in vivo synaptic plasticity in dentate gyrus and spatial memory in juvenile rats induced by prenatal morphine exposure

Hypothalamo-Pituitary-Adrenal Axis-Regulated Stress Response and Negative Feedback Sensitivity Is Altered by Prenatal Morphine Exposure in Adult Female Rats

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