Effects of prenatal exposure to deltamethrin on forced swimming behavior, motor activity, and striatal dopamine levels in male and female rats

Lazarini, Carlos Alberto; Flório, Jorge Camilo; Lemonica, Ione Pellegati; Bernardi, Maria Martha

doi:10.1016/s0892-0362(01)00170-2

Cited by 75 publications

(41 citation statements)

References 31 publications

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“…Maternal and offspring body weight, physical and reflex development were unaffected by exposure to the pesticide. No changes were observed in swimming and open-field behaviour, nor were there any changes in striatal monoamines or their metabolites in the male and female offspring (Lazarini et al, 2001). …”

Section: 72mentioning

confidence: 88%

Differential Behavioral Responses of <I>Anopheles gambiae</I> (Diptera: Culicidae) Modulate Mortality Caused by Pyrethroid-Treated Bednets

Siegert¹,

Walker²,

Miller³

2009

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Section: 72mentioning

confidence: 88%

Differential Behavioral Responses of <I>Anopheles gambiae</I> (Diptera: Culicidae) Modulate Mortality Caused by Pyrethroid-Treated Bednets

Siegert¹,

Walker²,

Miller³

2009

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“…Therefore, activity in the elevated plus maze, social interaction, rectal temperature, and neurotransmitter levels were evaluated 120 min after treat- by exposure to different types of pyrethroids, including DTM 3,15,26,27,28,29 . Interestingly, the decreased locomotor and rearing frequencies were followed by an increased duration of immobility.…”

Section: Discussionmentioning

confidence: 99%

“…Aspects of open field behavior and catalepsy 11,12 , conditioned behavior 12,13,14 , motor activity 15,16 , anxiety 11,17 and aggressive behavior 11 .…”

Section: Deltamethrin (Dtm [(S)-a-cyano-d-phenoxyben-mentioning

confidence: 99%

Evidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratos

Ricci

Ferreira

Habr

et al. 2013

Braz. J. Vet. Res. Anim. Sci.

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Pyrethroid insecticides are extensively used for pest control around the house, flea prevention for pets, and plant sprays for the home and in agriculture. Deltamethrin (DTM) is a Type II pyrethroid insecticide used to control a variety of insects in agriculture and domestic environments. The present study investigated the possible anxiogenic effects of DTM (1, 3, and 10 mg/kg) in rats using behavioral and neurochemical methods. We assessed general locomotor activity and behavior in the elevated plus maze and open field test. Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) increased striatal serotonin neurotransmitter and its metabolite, and (vii) did not alter motor coordination on the rotarod, grooming duration in the open field test, rectal temperature, or hippocampal neurotransmitter levels. These data suggest that DTM at the present doses and under these experimental conditions presented a similar profile to that of anxiogenic drugs, unrelated with the increased serotonin neurotransmission.Keywords: Deltamethrin. Pyrethroid. Anxiety. Behavior. Central neurotransmitters. ResumoInseticidas piretróides são amplamente utilizados para controle de pragas, como na prevenção de pulgas em animais de estimação e sprays de plantas para a casa e na agricultura. Deltametrina (DTM) é um inseticida piretróide tipo II usado para controlar uma variedade de insetos na agricultura e ambientes domésticos. O presente estudo investigou os possíveis efeitos ansiogênicos de DTM (1, 3 e 10 mg/kg) em ratos, utilizando métodos comportamentais e neuroquímicos. Foi avaliada a atividade locomotora geral e comportamento no labirinto em cruz elevado e teste de campo aberto. Os níveis de neurotransmissores e metabólitos no estriado e hipocampo também foram mensurados. DTM (i) reduziu a locomoção e a frequência de levantar, (ii) aumentou da duração da imobilidade, (iii) reduziu o tempo de interacção social, (iv) reduziu a percentagem de entradas e tempo gasto nos braços abertos do elevado labirinto em cruz, (v) reduziu o número de cruzamentos no centro do labirinto em cruz elevado, (vi) aumentou neurotransmissor serotonina e de seu metabólito estriatal, e (vii) não alterou a coordenação motora no rotarod, duração do grooming no teste de campo aberto, temperatu...

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“…Monoamine and metabolite levels (μg/g of tissue) and metabolite/neurotransmistter ratios of adult offspring rats exposed to ayahuasca during gestation and lactation period (GD6 to LD10). activity (Lazarini et al, 2001). It is possible to suggest that the reduction in latency to float observed here was the consequence of decreased motor activity.…”

Section: Discussionmentioning

confidence: 55%

Neurobehavioral, reflexological and physical development of Wistar rat offspring exposed to ayahuasca during pregnancy and lactation

Oliveira¹,

Moreira²,

Yonamine³

2011

Rev. bras. farmacogn.

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Ayahuasca is a hallucinogenic beverage prepared by the decoction of plants native to the Amazon Basin region. The beverage has been used throughout the world by members of some syncretic religious movements. Despite the recent legalization of ayahuasca in Brazil for religious purposes, there is little pre-clinical and clinical information attesting to its safety, particularly in relation to the use during pregnancy. The aim of the current work was to determine the effects of perinatal exposure to ayahuasca (from the 6 th day of pregnancy to the 10 th day of lactation) on physical, reflexology and neurobehavioral parameters of the Wistar rat offspring. The offspring showed no statistically significant changes in the physical and reflexology parameters evaluated. However, in adult rats, perinatally exposed to ayahuasca, an increase in frequency of entries in open arms in elevated plus-maze test, a decrease in total time of interaction in social interaction test, a decrease in time of latency for the animal to start swimming and a decrease of the minimum convulsant dose induced by pentylenetetrazol were observed. In conclusion, our results showed that the use of ayahuasca by mothers during pregnancy and lactation reduced the general anxiety and social motivation of the rat offspring. Besides, it promoted a higher sensitivity for initiation and spread of seizure activity.

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Effects of prenatal exposure to deltamethrin on forced swimming behavior, motor activity, and striatal dopamine levels in male and female rats

Cited by 75 publications

References 31 publications

Differential Behavioral Responses of <I>Anopheles gambiae</I> (Diptera: Culicidae) Modulate Mortality Caused by Pyrethroid-Treated Bednets

Differential Behavioral Responses of <I>Anopheles gambiae</I> (Diptera: Culicidae) Modulate Mortality Caused by Pyrethroid-Treated Bednets

Evidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratos

Neurobehavioral, reflexological and physical development of Wistar rat offspring exposed to ayahuasca during pregnancy and lactation

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