Effects of prenatal exposure to maternal COVID-19 and perinatal care on neonatal outcome: results from the INTERCOVID Multinational Cohort Study

Giuliani, Francesca; Orós, Daniel; Gunier, Robert B.; Deantoni, Sonia; Rauch, Stephen; Casale, Roberto; Nieto, Ricardo; Bertino, Enrico; Rego, Albertina; Menis, Camilla; Gravett, Michael G.; Candiani, Massimo; Deruelle, Philippe; García-May, Perla Karina; Mhatre, Mohak; Usman, Mustapha Ado; Abd‐Elsalam, Sherief; Etuk, Saturday; Napolitano, R.; Liu, Becky; Prefumo, Federico; Savasi, Valeria; Silva, Marynéa; Baafi, Eric; Ariff, Shabina; Maíz, Nerea; Aminu, Muhammad Baffah; Cardona–Pérez, Jorge Arturo; Craik, Rachel; Tavchioska, Gabriela; Bako, Babagana; Benski, Caroline; Hassan-Hanga, Fatima; Savorani, Mónica; Sentilhes, Loïc; Capelli, Maria Carola; Takahashi, Ken; Vecchiarelli, Carmen; Ikenoue, Satoru; Thiruvengadam, Ramachandran; Conti, Constanza P. Soto; Cetin, Irene; Nachinab, Vincent Bizor; Ernawati, Ernawati; Duro, Eduardo Alfredo; Kholin, Alexey; Teji, Jagjit S.; Easter, Sarah Rae; Salomon, Laurent; Ayede, Adejumoke Idowu; Cerbo, Rosa Maria; Agyeman-Duah, Josephine; Roggero, Paola; Eskenazi, Brenda; Langer, Ana; Bhutta, Zulfiqar Ahmed; Kennedy, Stephen; Papageorghiou, A.T.; Villar, José

doi:10.1016/j.ajog.2022.04.019

Cited by 50 publications

(43 citation statements)

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“…Pregnant women who are infected with SARS-CoV-2 have an increased risk of severe COVID-19, including increased risk of hospital admission, intensive care unit admission, and requiring mechanical ventilation (Safadi et al, 2022). Moreover, despite the fact that risk of vertical transmission of SARS-CoV-2 is estimated to be under 5%, maternal infection during pregnancy also increases the risk of negative fetal outcomes including preterm birth, decreased birth weight, fetal distress in labour, neonatal intensive care unit admission, and stillbirth (Giuliani et al, 2022;Safadi et al, 2022). Additionally, it is possible that prenatal SARS-CoV-2 infection may have long-term implications for offspring neurodevelopment.…”

Section: Infection During Pregnancy Downregulates the Expression Of A...mentioning

confidence: 99%

“…Additionally, it is possible that prenatal SARS-CoV-2 infection may have long-term implications for offspring neurodevelopment. It is well established that various bacterial and viral infections, when contracted during pregnancy, increase the chance of the offspring having a neurodevelopmental disorder such as autism spectrum disorder or schizophrenia (Sorensen et al, 2009;Atladttir et al, 2010;Brown and Derkits, 2010;Jiang et al, 2016;Giuliani et al, 2022). Emerging evidence suggests that offspring resulting from pregnancies complicated by COVID-19 may exhibit developmental delays, implying that SARS-CoV-2 infection may similarly increase the chance of neurodevelopmental disorders (Edlow et al, 2022).…”

Section: Infection During Pregnancy Downregulates the Expression Of A...mentioning

confidence: 99%

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COVID-19 Vaccines and the Virus: Impact on Drug Metabolism and Pharmacokinetics

et al. 2022

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List of non-standard abbreviations: alanine serine cysteine transporter (ASCT), antibody-drug conjugates (ADCs), excitatory amino acid transporter (EAAT), gamma aminobutyric acid (GABA), glycine transporter (GLYT), interferon (IFN), interleukin (IL), mean fluorescence intensity (MFI), nuclear factor kappa B (NF-κB), post-acute covid-19 syndrome (PACS), pegylated (PEG), polyinosinic:polycytidylic acid (Poly(I:C)), small neutral amino acid transporter (SNAT)

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Section: Infection During Pregnancy Downregulates the Expression Of A...mentioning

confidence: 99%

Section: Infection During Pregnancy Downregulates the Expression Of A...mentioning

confidence: 99%

COVID-19 Vaccines and the Virus: Impact on Drug Metabolism and Pharmacokinetics

et al. 2022

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“…Studies have shown that compared to non-pregnant women, pregnant women are significantly more likely to be hospitalized, admitted to intensive care units (ICU), receive invasive ventilation or extracorporeal membrane oxygenation (ECMO), and die [ 10 – 16 ]. In addition, results from a multinational cohort study pointed out a higher rate of pregnancy related complications, such as hypertensive disorders of pregnancy and fetal distress [ 17 ]. There is evidence of significantly elevated risk of preterm birth [ 13 – 17 ] and lower neonatal weight [ 17 ] among SARS-CoV-2 affected pregnancies when compared with pregnant women without SARS-CoV-2 infection, even in milder disease.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, results from a multinational cohort study pointed out a higher rate of pregnancy related complications, such as hypertensive disorders of pregnancy and fetal distress [ 17 ]. There is evidence of significantly elevated risk of preterm birth [ 13 – 17 ] and lower neonatal weight [ 17 ] among SARS-CoV-2 affected pregnancies when compared with pregnant women without SARS-CoV-2 infection, even in milder disease. Also, the neonates who tested positive (born to COVID-19 positive mothers) had worse outcomes, with higher rates of ICU admission, fever, gastrointestinal and respiratory symptoms and death, even after adjusting for prematurity [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…There is evidence of significantly elevated risk of preterm birth [ 13 – 17 ] and lower neonatal weight [ 17 ] among SARS-CoV-2 affected pregnancies when compared with pregnant women without SARS-CoV-2 infection, even in milder disease. Also, the neonates who tested positive (born to COVID-19 positive mothers) had worse outcomes, with higher rates of ICU admission, fever, gastrointestinal and respiratory symptoms and death, even after adjusting for prematurity [ 17 ]. Therefore, this complicated disease course seems to compromise the development and survival of the fetus and neonate, although robust, organized, homogeneous information on the effect of COVID-19 on perinatal, neonatal and long-term outcomes remain insufficient [ 18 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Monitoring SARS-CoV-2 seroprevalence over time among pregnant women admitted to delivery units: Suitability for surveillance

et al. 2023

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Objectives To determine SARS-CoV-2 seroprevalence over time and risk factors among pregnant women at delivery in São Paulo, Brazil; and to evaluate the suitability of pregnant women as a sentinel population for SARS-CoV-2 serosurveillance. Methods Unselected consecutive pregnant women presenting at the labor ward of a single large hospital between July 20th 2020 to February 21st 2021 were enrolled and tested for SARS-CoV-2 serology using two assays: the rapid chromatic Wondfo One Step (for total IgA and IgG detection) and Roche Elecsys assay (detecting anti-nucleoprotein [N] IgG). SARS-CoV-2 seroprevalence was computed as smooth spline function over time with 95% confidence intervals (CI). Risk factors were evaluated for positivity by each assay. We compared timepoint seroprevalence by the two assays with four concomitant community household surveys (HHS), in which the Roche assay was used, to determine the sensitivity and relevance of the pregnant women population as sentinel population. Results Overall SARS-CoV-2 seroprevalence was 28.9% (221/763) by Roche and 17.9% (137/763) by Wondfo. Reported symptoms experienced during pregnancy were all significantly correlated with being SARS-CoV-2 seropositive at delivery with any assay (with odds-ratios ranging from 3.0 [95% CI: 2.1–4.3] for coryza to 22.8 [95% CI: 12.3–46.6] for ageusia). Seropositivity by either assay was high in women at delivery in the early period of the pandemic (June 2020), compared with seropositivity in women from the concomitant HHS: 44.1% (95% CI: 21.8–66.4) for Roche, 54.1% (30.9–78.5) for Wondfo, versus 11.4% (95% CI: 9.2–13.6) for HHS. For later periods (October 2020 and January 2021), the seropositivity in women at delivery measured by Roche corresponded well with the prevalence found among women in the HHS using the same assay, whilst prevalence measured by Wondfo dropped. Conclusions Women at delivery represent a highly exposed and readily accessible population for sentinel surveillance of emerging infections such as SARS-CoV-2.

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Comparison and discussion of behavior and pathology of four kinds of cerebral palsy disease models

Xu,

Yan,

Xia

et al. 2024

Intl J of Devlp Neuroscience

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Explore the differences in behavioral and pathological manifestations of rat models of cerebral palsy made by different methods and discuss what types of studies these models are suitable for. Behavioral evaluation and pathological section observation were used to observe and evaluate the model. Conclusion: except for the absence of data of bilateral common carotid artery ligation rats, the other three methods could all achieve a successful cerebral palsy disease model for both behavioral and pathological. For researchers, the selection of intraperitoneal infection model in pregnant rats or unilateral ischemia and hypoxia model in infant rats is sufficient to meet the experimental needs, whereas the selection of the combined method for modeling does not show enough advantages, which not only causes the waste of financial and human resources but also increases the possibility of experimental error made by intervention factors.

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Effects of prenatal exposure to maternal COVID-19 and perinatal care on neonatal outcome: results from the INTERCOVID Multinational Cohort Study

Cited by 50 publications

References 34 publications

COVID-19 Vaccines and the Virus: Impact on Drug Metabolism and Pharmacokinetics

COVID-19 Vaccines and the Virus: Impact on Drug Metabolism and Pharmacokinetics

Monitoring SARS-CoV-2 seroprevalence over time among pregnant women admitted to delivery units: Suitability for surveillance

Comparison and discussion of behavior and pathology of four kinds of cerebral palsy disease models

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