Effects of prenatal and postnatal exposure to vitamin A on the development of the murine immune system

Guzman, Juan J.; Caren, Linda D.

doi:10.1016/0024-3205(91)90044-c

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…VA and b-carotene supplementation variously increased lymphocyte numbers in early and midpregnancy and increased T:B-cell ratios (151). In addition, in mice, maternal VA supplementation via intraperitoneal injections increased serum IgM and T-helper cell (Th) 2-specific IgG1 concentrations in the progeny (152). Nevertheless, during the first month of lactation in a human b-carotene supplementation study neither lactation nor b-carotene supplementation affected T-cell proliferation (153).…”

Section: Biological and Functional Clinical Tests A Close Associatiomentioning

confidence: 96%

“…T-effector cells differentiate into several subtypes and include Th1 (defense against intracellular bacteria and protozoa), Th2 (humoral immune stimulators against extracellular parasites), Th17 (proinflammatory autoimmunity regulators), and immunosuppressive T-regulatory cells. In postnatal development, VA regulates the Th1:Th2 switch and thereby modifies immune and inflammatory responses (152,154).…”

Section: Biological and Functional Clinical Tests A Close Associatiomentioning

confidence: 99%

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Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models

Rubin

Ross

Stephensen

et al. 2017

Advances in Nutrition

119

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The association between inflammation and vitamin A (VA) metabolism and status assessment has been documented in multiple studies with animals and humans. The relation between inflammation and carotenoid status is less clear. Nonetheless, it is well known that carotenoids are associated with certain health benefits. Understanding these relations is key to improving health outcomes and mortality risk in infants and young children. Hyporetinolemia, i.e., low serum retinol concentrations, occurs during inflammation, and this can lead to the misdiagnosis of VA deficiency. On the other hand, inflammation causes impaired VA absorption and urinary losses that can precipitate VA deficiency in at-risk groups of children. Many epidemiologic studies have suggested that high dietary carotenoid intake and elevated plasma concentrations are correlated with a decreased risk of several chronic diseases; however, large-scale carotenoid supplementation trials have been unable to confirm the health benefits and in some cases resulted in controversial results. However, it has been documented that dietary carotenoids and retinoids play important roles in innate and acquired immunity and in the body's response to inflammation. Although animal models have been useful in investigating retinoid effects on developmental immunity, it is more challenging to tease out the effects of carotenoids because of differences in the absorption, kinetics, and metabolism between humans and animal models. The current understanding of the relations between inflammation and retinoid and carotenoid metabolism and status are the topics of this review.

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Section: Biological and Functional Clinical Tests A Close Associatiomentioning

confidence: 96%

Section: Biological and Functional Clinical Tests A Close Associatiomentioning

confidence: 99%

Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models

Rubin

Ross

Stephensen

et al. 2017

Advances in Nutrition

119

View full text Add to dashboard Cite

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“…These results confirm that supplementation with vitamin A and b-carotene affects immune cell functions during ontogenesis. However, maternal vitamin A supplementation via intraperitoneal injections has been shown to increase serum IgM and Th2-specific IgG1 levels in the progeny (Guzman & Caren, 1991). Furthermore, in a human supplementation study (Gossage et al 2000), which investigated the effects of b-carotene supplementation during early lactation (days 4-32 post partum) on circulating carotenoids and the T-cell proliferative response to phytohaemagglutinin, it has been found that neither lactation nor b-carotene supplementation affects T-cell proliferation.…”

Section: Effects Of Carotenoids and Retinoids On Immune Developmentmentioning

confidence: 99%

Effects of dietary retinoids and carotenoids on immune development

Rühl

2007

Proc. Nutr. Soc.

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Carotenoids and retinoids are groups of nutritionally-relevant compounds present in many foods of plant origin (carotenoids) and animal origin (mainly retinoids). Their levels in human subjects vary depending on the diversity and amount of the individual's nutrient intake. Some carotenoids and retinoids have been investigated for their effects on the immune system bothin vitroandin vivo. It has been shown that retinoids have the potential to mediate or induce proliferative and differentiating effects on several immune-competent cells, and various carotenoids are known to be inducers of immune function. The immune-modulating effects of retinoids have been well documented, while the effects of carotenoids on the immune system have not been investigated as extensively, because little is known about their molecular mechanism of action. The present review will mainly focus on the molecular mechanism of action of retinoids and particularly carotenoids, their nutritional origin and intake, their transfer from the maternal diet to the child and their effects or potential effects on the developing immune system.

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“…25 Maternal VA supplementation (intraperitoneal) increased serum IgM and IgG1 levels in the progeny. 26 Respectively, the transfer of VA from mother to offspring by milk, and the VA status of dams and suckling neonates, is in¯uenced by maternal VA intake during lactation. 27,28 Nutritionally relevant carotenoids, such as lycopene and bcarotene, have been proposed to enhance cell-mediated immune responses, 29±32 but the exact mechanism of action is still unclear.…”

Section: Introductionmentioning

confidence: 99%

“…RA has been demonstrated to inhibit B‐cell proliferation and immunoglobulin E (IgE) synthesis in cell‐culture studies via RARs receptors 25 . Maternal VA supplementation (intraperitoneal) increased serum IgM and IgG1 levels in the progeny 26 . Respectively, the transfer of VA from mother to offspring by milk, and the VA status of dams and suckling neonates, is influenced by maternal VA intake during lactation 27,28 …”

Section: Introductionmentioning

confidence: 99%

Retinoid‐ and carotenoid‐enriched diets influence the ontogenesis of the immune system in mice

et al. 2003

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SUMMARYVitamin A (VA) has been identi®ed as an important factor for the development of the immune system, especially during ontogenesis. It has been shown that antibody secretion and proliferation of lymphocyte populations depend on retinoids. In the present study we investigated the in¯uence of a base VA diet and diets enriched with VA, b-carotene and lycopene, on the ontogenesis of the immune system in mice. We examined the absolute and relative concentrations of splenic B lymphocytes (CD45R/B220), T lymphocytes (CD3 ) and their subpopulations (CD4 and CD8 ), and measured serum immunoglobulin G (IgG) concentrations in the offspring of supplemented dams at different ages (1, 3, 5, 7, 14, 21 and 65 days). The experimental diets resulted in higher numbers of T and B lymphocytes after VA and carotenoid enrichment, when compared, at various time-points, with the base diet. Higher values of total serum IgG were found in the b-carotene-enriched diet group on day 7. On days 7 and 14, the enriched diets induced signi®cant alterations in the percentages and total numbers of splenic lymphocytes in comparison to the base diet. Our results con®rm that supplementation with VA and carotenoids affect the immune-cell function during ontogenesis and suggest a possible role of these nutritional factors on the development of the immune system.

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Effects of prenatal and postnatal exposure to vitamin A on the development of the murine immune system

Cited by 6 publications

References 10 publications

Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models

Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models

Effects of dietary retinoids and carotenoids on immune development

Retinoid‐ and carotenoid‐enriched diets influence the ontogenesis of the immune system in mice

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