Effects of Prenatal Alcohol Exposure on Attention and Working Memory at 7.5 Years of Age

Burden, Matthew J.; Jacobson, Sandra W.; Sokol, Robert J.; Jacobson, Joseph L.

doi:10.1097/01.alc.0000156125.50577.ec

Cited by 140 publications

(138 citation statements)

References 45 publications

Supporting

Mentioning

130

Contrasting

Order By: Relevance

“…This finding is consistent with a previous report of impaired working memory in a much smaller sample of VPA-exposed children (Kantola-Sorsa et al, 2007), and with reports of impaired attention and working memory in children exposed prenatally to other neurotoxic substances (Burden et al, 2005;Fried & Watkinson, 2001).…”

Section: Discussionsupporting

confidence: 92%

The Australian Brain and Cognition and Antiepileptic Drugs Study: IQ in School-Aged Children Exposed to Sodium Valproate and Polytherapy

Nadebaum

Anderson

Vajda

et al. 2010

J Int Neuropsychol Soc

View full text Add to dashboard Cite

Prenatal exposure to sodium valproate (VPA) and polytherapy has been linked with increased risk of birth defects and cognitive impairment in young children. We evaluated the cognitive impact of prenatal exposure to VPA and polytherapy in school-aged children. Fifty-seven children exposed to VPA (n 5 23), polytherapy with VPA (n 5 15), or polytherapy without VPA (n 5 19) were assessed using the Wechsler Intelligence Scale for Children-Fourth Edition. Information on maternal epilepsy, pregnancy, and medical history was obtained prospectively through the Australian Pregnancy Register for Women with Epilepsy and Allied Disorders. All groups had elevated frequencies of Extremely Low (,70) or Borderline (70-79) Full-Scale IQ (15.8-40.0%). Verbal Comprehension and Working Memory scores in all groups fell significantly below the standardized test mean, while Perceptual Reasoning and Processing Speed scores were relatively intact. Multivariate analysis of covariance analysis revealed significant main effects of VPA on Verbal Comprehension and Working Memory, and of polytherapy on Verbal Comprehension and Processing Speed. Our results suggest that VPA has a dose-dependent negative impact on verbal intellectual abilities, and may also affect working memory. The possibility that inclusion of VPA in many polytherapy regimens may underlie reduced mean scores of polytherapyexposed children is discussed. (JINS, 2011, 17, 133-142)

show abstract

Section: Discussionsupporting

confidence: 92%

The Australian Brain and Cognition and Antiepileptic Drugs Study: IQ in School-Aged Children Exposed to Sodium Valproate and Polytherapy

Nadebaum

Anderson

Vajda

et al. 2010

J Int Neuropsychol Soc

View full text Add to dashboard Cite

show abstract

“…Compared with controls, children exposed prenatally to more than • 1.4 standard drinks per day in utero had deficits in working memory and executive function but not impulsivity or sustained attention at 7.5 years of age (Burden et al 2005a;Burden et al 2005b) -the effect, which increased with increasing alcohol consumption, was most marked for numeracy tasks and persisted after controlling for IQ. In both studies, adverse effects were more pronounced in children born to mothers aged 30 years or more.…”

Section: Alcohol Exposure and Outcomes In Childhood And Adolescencementioning

confidence: 85%

Survey of alcohol-related presentations to Australasian emergency departments

et al. 2014

View full text Add to dashboard Cite

Objective: To determine the proportion of alcohol‐related presentations to emergency departments (EDs) in Australia and New Zealand, at a single time point on a weekend night shift. Design, setting and participants: A point prevalence survey of ED patients either waiting to be seen or currently being seen conducted at 02:00 local time on 14 December 2013 in 106 EDs in Australia and New Zealand. Main outcome measures: The number of ED presentations that were alcohol‐related, defined using World Health Organization ICD‐10 codes. Results: At the 106 hospitals (92 Australia, 14 New Zealand) that provided data, 395 (14.3%; 95% CI, 13.0%–15.6%) of 2766 patients in EDs at the study time were presenting for alcohol‐related reasons; 13.8% (95% CI, 12.5%–15.2%) in Australia and 17.9% (95% CI, 13.9%–22.8%) in New Zealand. The distribution was skewed left, with proportions ranging from 0 to 50% and a median of 12.5%. Nine Australian hospitals and one New Zealand hospital reported that more than a third of their ED patients had alcohol‐related presentations; the Northern Territory (38.1%) and Western Australia (21.1%) reported the highest proportions of alcohol‐related presentations. Conclusions: One in seven ED presentations in Australian and New Zealand at this 02:00 snapshot were alcohol‐related, with some EDs seeing more than one in three alcohol‐related presentations. This confirms that alcohol‐related presentations to EDs are currently underreported and makes a strong case for public health initiatives.

show abstract

“…The report of the Birth Defects Monitoring Program completed by the Centres for Disease Control (CDC), based on data from 1500 hospitals, suggests that the prevalence of reported FAS cases in the U.S. population is 0.3-0.9 per 10,000 births [9]. On the other hand, Abel and Sokolow, after reviewing 19 epidemiological works from around the world, evaluated the prevalence of FAS at 1.9 per 1000 live births [9].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, Abel and Sokolow, after reviewing 19 epidemiological works from around the world, evaluated the prevalence of FAS at 1.9 per 1000 live births [9]. According to the CDC report, incidence rates of FAS in 10,000 births vary depending on the ethnicity of mothers [9].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The impact of sensory integration therapy on gross motor function in children after prenatal exposure to alcohol

Wilczyński¹,

Zawada²

2015

View full text Add to dashboard Cite

Słowa kluczowe: fizjoterapia, integracja sensoryczna, dzieci po prenatalnej ekspozycji na alkohol. AbstractIntroduction: In Poland there are 900 cases of full-blown foetal alcohol syndrome (FAS) in neonates per year, and in 9000 children there are some symptoms of it. Aim of the research: To analyse the impact of sensory integration (SI) therapy on gross motor skills function in children after prenatal exposure to alcohol. Material and methods: The study was conducted on a group of 20 children aged 4-5 years with information from an interview about prenatal exposure to alcohol. The diagnosis of sensory integration disorder consisted of two 60-minute diagnostics meetings. Twelve trials with clinical observations were performed by Ayres: finger to nose, cocontraction, prone extension posture, flexed position supine, asymmetrical tonic neck reflex (ATOS), symmetrical tonic neck reflex (STOS), muscle tension, Schilder test, dynamic balance, static balance, gravitational insecurity, and trunk stabilisation. The therapeutic program included: normalisation of the vestibular and proprioceptive system, normalisation of the touch system, strengthening muscle tension, development of motion planning, development of oculomotor performance, development of motor coordination, hand therapy, integration of ATOS, STOS, development of locomotion and balance functions, and improving efficiency of gross and small motor skills. Results and conclusions: High efficiency of SI therapy has been shown in children after prenatal exposure to alcohol on the example of gross motor skills. Positive effects of SI therapy have been shown for tests: finger to nose, in the erect position on the stomach, the flexural position on the back, ATOS, STOS, Schilder test, dynamic balance, static balance, and the uncertainty of gravity and trunk stabilisation. Only cocontraction and muscle tension tests showed no efficacy of SI therapy. The a-Cronbach position analysis showed high reliability of the performed tests both before and after the therapy. It is advisable to continue the study on a larger sample and observation of the functional status of children after therapy.

show abstract

Effects of Prenatal Alcohol Exposure on Attention and Working Memory at 7.5 Years of Age

Abstract: These data confirm previous studies using diverse methods that suggest that working memory may be the most important aspect of attention that is adversely affected by prenatal alcohol exposure.

Cited by 140 publications

References 45 publications

The Australian Brain and Cognition and Antiepileptic Drugs Study: IQ in School-Aged Children Exposed to Sodium Valproate and Polytherapy

The Australian Brain and Cognition and Antiepileptic Drugs Study: IQ in School-Aged Children Exposed to Sodium Valproate and Polytherapy

Survey of alcohol-related presentations to Australasian emergency departments

The impact of sensory integration therapy on gross motor function in children after prenatal exposure to alcohol

Contact Info

Product

Resources

About