Effects of prenatal administration of testosterone and cortisone on the reproductive system of the female rat

McCoy, Sarah J. Breese; Shirley, Barbara

doi:10.1016/0024-3205(92)90248-n

Cited by 22 publications

(16 citation statements)

References 17 publications

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“…In a study performed by Henly et al [36], who used similar procedures to evaluate sexual behavior and sexual preference, no differences were found. An important difference between these experiments was the dose of TP and the period of treatment; in our study we used 1 mg/ animal/day on GD 17,18,and 19 whereas Henly et al [36] used 2 mg/0.1 ml/day on GD 16,17,18,19,and 20. Also in this study, males treated with TP from the day of birth through PND 21 and tested as intact adults spent more time with a sexually active male than with control males.…”

Section: Discussionmentioning

confidence: 99%

“…The dose used was on a per rat basis, without correction for body weight, in order to replicate methods used extensively by other investigators [5,19,20]. Additionally, a 1-mg dose was used because higher doses induce adverse effects including loss of litters, delayed delivery, decrease in pup weight, and extensive mortality in F1 females after weaning, because of reproductive tract malformations [5].…”

Section: Experimental Groupsmentioning

confidence: 99%

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Prenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male rats

Cruz

Pereira

2012

J Physiol Sci

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The objective of this study was to investigate whether prenatal exposure to testosterone (T) could change the body weight (BW), anogenital distance (AGD), anogenital distance index (AGDI), puberty onset, social behavior, fertility, sexual behavior, sexual preference, and T level of male rats in adulthood. To test this hypothesis, pregnant rats received either 1 mg/animal of T propionate diluted in 0.1 ml peanut oil or 0.1 ml peanut oil, as control, on the 17th, 18th and 19th gestational days. No alterations in BW, AGD, AGDI, fertility, and sexual behavior were observed (p > 0.05). Delayed onset of puberty (p < 0.0001), increased aggressive behavior (p > 0.05), altered pattern of sexual preference (p < 0.05), and reduced T plasma level (p < 0.05) were observed for adult male rats exposed prenatally to T. In conclusion, the results showed that prenatal exposure to T was able to alter important aspects of sexual and social behavior although these animals were efficient at producing descendants. In this sense more studies should be carried to evaluated the real impact of this hormonal alteration on critical period of sexual differentiation on humans, because pregnant women exposed to hyperandrogenemia and then potentially exposing their unborn children to elevated androgen levels in the uterus can undergo alteration of normal levels of T during the sexual differentiation period, and, as a consequence, affect the reproductive and behavior patterns of their children in adulthood.

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Section: Discussionmentioning

confidence: 99%

Section: Experimental Groupsmentioning

confidence: 99%

Prenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male rats

Cruz

Pereira

2012

J Physiol Sci

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“…Not only are effects in other organ systems likely, but other hormonal activities are probable. For example, while the presence of environmental androgens has not been well studied or substantiated, recent cases in wildlife suggest that environmental androgens do exist [83][84][85]. A logical, prospective design that systematically evaluates those tissues that we know are steroid responsive would be necessary and not overly difficult.…”

Section: J C O'connor and R E Chapinmentioning

confidence: 99%

“…Adverse effects associated with androgenic exposure in females include increased AGD (i.e., male-like), delayed puberty, altered estrous cyclicity, and masculinization (e.g., decreased number of areolas/nipples, presence of male reproductive tissues) [83][84][85]. Numerous documented cases of alterations in female sexual behavior are also common [83,86,87].…”

Section: Adverse Effects Of Endocrine Active Substances On Reproductimentioning

confidence: 99%

“…In females, AR agonists produce masculinizing effects, both morphologically and behaviorally [83][84][85]. Adverse effects associated with androgenic exposure in females include increased AGD (i.e., male-like), delayed puberty, altered estrous cyclicity, and masculinization (e.g., decreased number of areolas/nipples, presence of male reproductive tissues) [83][84][85].…”

Section: Adverse Effects Of Endocrine Active Substances On Reproductimentioning

confidence: 99%

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Critical evaluation of observed adverse effects of endocrine active substances on reproduction and development, the immune system, and the nervous system

O’Connor

Chapin

2003

Pure and Applied Chemistry

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The last 40 years have seen many reports that man-made chemicals and environmental pollutants cause adverse effects in humans and wildlife; however, actually linking an exposure with a mechanism and an effect has yet to be done for endocrine disruption. Certainly, studies in experimental animals have shown that sufficient doses of select compounds can disrupt the endocrine system and produce the attendant adverse outcomes. The purpose of this contribution is to evaluate some of the recent reports of the adverse effects on reproduction and development, the immune system, and the nervous system that have been observed in experimental animals after treatment with man-made chemicals and environmental pollutants. Space limitations prevent us from presenting a comprehensive review of all reported endocrine active chemicals and their effects. Instead, we have focused on drawing conclusions as to the scope and etiology of the adverse effects in experimental animals using examples from the scientific literature, and on suggesting a path forward for further work.

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Variation in reproductive traits is associated with short anogenital distance in female rats

Zehr

Gans

McClintock

2001

Developmental Psychobiology

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Anogenital distance was used as a biomarker for natural variation in prenatal androgenization of female rats and was associated with individual differences in a suite of reproductive characteristics. Females with short anogenital distances were likely to have first vaginal estrus earlier than females with longer anogenital distances and to have first vaginal estrus on the same day as vaginal opening. In young adulthood, females with short anogenital distances had shorter ovarian cycles and less intense lordosis reflexes in response to manual palpation than those with longer anogenital distances, but only when living individually, not in groups. Taken together, these findings indicate that prenatal androgenization affects reproductive traits throughout the life span.

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Effects of prenatal administration of testosterone and cortisone on the reproductive system of the female rat

Cited by 22 publications

References 17 publications

Prenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male rats

Prenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male rats

Critical evaluation of observed adverse effects of endocrine active substances on reproduction and development, the immune system, and the nervous system

Variation in reproductive traits is associated with short anogenital distance in female rats

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