Effects of Pregnancy, Hypertension and Nitric Oxide Inhibition on Rat Uterine Artery Myogenic Reactivity

Barron, Carolyn; Mandalà, Maurizio; Osol, George

doi:10.1159/000313874

Cited by 20 publications

(25 citation statements)

References 83 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6,24 A recent study showed that L-NAME significantly increased myogenic tone. 22 We found that inhibition of eNOS with L-NAME enhanced the NaHS-induced reduction of the myogenic response, indicating an interaction between H2S and NO and that this interaction may generate nitrosothiol, which exhibits little or no vasorelaxant activity. 10, 34 The NO-induced vasorelaxation is mainly mediated by the cGMP pathway, but not the cAMP pathway.…”

Section: Discussionmentioning

confidence: 72%

Effects of H<sub>2</sub>S on Myogenic Responses in Rat Cerebral Arterioles

Liu

Sun

et al. 2012

Circ J

View full text Add to dashboard Cite

Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp he vascular myogenic response is the rapid and maintained constriction of a blood vessel in response to pressure elevation. At physiological pressure levels, the vascular myogenic response produces a tonic arteriolar constriction necessary for the action of vasodilators. The myogenic response participates in local regulation of blood flow and protects dependent capillary beds from the large increases in hydrostatic pressure induced by postural changes. 1 The myogenic responses are generated exclusively by vascular smooth muscle, 2 the tone generated by this mechanism can be modulated by factors released from the endothelium 3,4 and other tissues.Hydrogen sulfide (H2S) has been best known for decades as the toxic gas dubbed "rotten egg gas". 5 Recently, H2S has been recognized as a novel gasotransmitter alongside nitric oxide (NO) and carbon monoxide. In the cardiovascular system of intact rats, H2S regulates vascular tone by relaxing blood vessels in vitro and decreasing blood pressure (BP). 6,7 Zhao et al also demonstrated that application of NaHS, a H2S donor, induces vasodilation of rat aortic rings in a concentration-dependent manner starting from 60 μmol/L. 6 The latest research has shown that H2S is a dilator of the newborn cerebral circulation and that endogenous cystathionine γ-lyase (CSE) can produce sufficient H2S to decrease vascular tone. 8 Despite the finding that H2S can cause vasorelaxation by activating ATP-sensitive K + channels (KATP channels), 6 the precise signaling mechanism for the effect of H2S on vascular myogenic response is still unclear.Because H2S induces vasodilatation, we hypothesized that prolonged exposure to H2S would alter KATP channel-dependent responses in cerebral arterioles. To this end, we aimed to study the effect of H2S on the myogenic response and mechanism of cerebral arterioles in rats. Methods AnimalsMale SD rats (age: 3 months) were used. Approval for the T

show abstract

Section: Discussionmentioning

confidence: 72%

Effects of H<sub>2</sub>S on Myogenic Responses in Rat Cerebral Arterioles

Liu

Sun

et al. 2012

Circ J

View full text Add to dashboard Cite

show abstract

“…High-quality nursing to puerpera with pregnancy hypertension mainly focuses on psychological nursing, ward environment nursing, disease observation, nursing for preeclampsia and eclampsia, and post-delivery nursing [8,9]. This type of care provides comprehensive, systematic, and thorough nursing services to puerpera, thus improving outcomes of puerpera and newborns [10].…”

Section: Discussionmentioning

confidence: 99%

Effects of high-quality nursing on puerpera with pregnancy hypertension

Li¹

2018

biomedicalresearch

View full text Add to dashboard Cite

Objective: This paper aims to discuss the clinical effects of high-quality nursing for puerpera with pregnancy hypertension. Methods: A total of 88 puerpera cases with pregnancy hypertension were collected from March 2016 to July 2017. Cases were randomly divided into two groups: control group (n=44) and intervention group (n=44). The control group was provided with conventional nursing, whereas the intervention group was treated with high-quality nursing. Comparisons were made on psychological state, blood pressure levels, incidences of pre-eclampsia and eclampsia, nursing satisfaction, newborn birth weight, and Apgar scores of the two groups. Results: Depression and anxiety scores of intervention group are significantly lower than those of control group (P<0.05). Diastolic pressure level and systolic pressure level of intervention group are far lower than those of the control group (P<0.05). Incidences of pre-eclampsia and eclampsia in the intervention group reached 18.2% and 4.5%, respectively, which are significantly lower than those of the control group (38.6% and 20.5%) (P<0.05). Nursing satisfaction of intervention group total of 97.7%, which is significantly higher than that of the control group (81.8%) (P<0.05). Newborn birth weight and Apgar scores of intervention group are significantly higher than those of control group (P<0.05). Conclusions: High-quality nursing features outstanding clinical effect on puerpera with pregnancy hypertension, improves psychological state and blood pressure level, and increases newborn birth weight effectively. Hence, high-quality nursing is a characteristic of safety and reliability and worthy of clinical promotion and applications.

show abstract

“…This was proofed by inhibition of NO will increased blood pressure of uterine arteries [16]. NO was produced by eNOS and iNOS.…”

Section: Placental Proreninmentioning

confidence: 92%

Analysis of Oxidative Stress Markers Malondialdehyde, Glutathione, Nitric Oxide, and Prorenin Level in Preeclampsia Placental Tissues

Prijanti

Marissa²,

Paramita

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Background: Preeclampsia was a syndrome of hypertension proteinuria in pregnant women. In failure of pseudo vasculogenesis, there is persistency of endothelial and smooth muscle cell of vessel wall in spiral artery. Spiral artery could not be emphasis and lead to relative hypoxia, and oxidative stress in placental tissues. Endothelial cell has property to produce nitric oxide (NO) that can dilated vessel. Placenta also produces prorenin, to maintain vascular wall tonicity. Therefore, we want to uncover the property of placenta is there any capacity of prorenin, is that prorenin could overcome the NO level, or is there any depression of NO production, and any oxidative stress.Methods: This observational study was used case-control design. We search preeclampsia cases during September-December 2015. We used preeclampsia placentas from early and late onset. We collect preeclampsia placentas from Cipto Mangunkusumo and normal placentas from Budi Kemuliaan Hospital. We used 30 preeclampsia placentas and 30 normal placentas. Markers measured were NO and prorenin. NO was measured using colorimetric assay kit (K262-200/ BioVision), and prorenin was measured using human prorenin enzyme-linked immunosorbent assay kit (ab157525/ Abcam). Glutathione (GSH) was measured using Ellman method and malondialdehyde (MDA) using Wills method. Results:Prorenin concentration between normal and preeclampsia placenta was analyzed using Mann-Whitney and show that there had no significant difference between preeclampsia and normal placentas (p=0.23). Besides, NO data analyzed using independent t-test show significant differences between preeclampsia and normal placentas (p=0.001). The difference between normal and preeclampsia GSH concentration was not significant (p=0.757), besides the difference between normal and preeclampsia MDA concentration was significant (p=0.000).Conclusion: NO concentration in preeclampsia placenta was increase, higher than normal placenta. There was no effect of preeclampsia on prorenin concentration and GSH. There was marked decrease of MDA in preeclampsia placentas.

show abstract

Effects of Pregnancy, Hypertension and Nitric Oxide Inhibition on Rat Uterine Artery Myogenic Reactivity

Cited by 20 publications

References 83 publications

Effects of H<sub>2</sub>S on Myogenic Responses in Rat Cerebral Arterioles

Effects of H<sub>2</sub>S on Myogenic Responses in Rat Cerebral Arterioles

Effects of high-quality nursing on puerpera with pregnancy hypertension

Analysis of Oxidative Stress Markers Malondialdehyde, Glutathione, Nitric Oxide, and Prorenin Level in Preeclampsia Placental Tissues

Contact Info

Product

Resources

About