Effects of prebiotics on immunologic indicators and intestinal microbiota structure in perioperative colorectal cancer patients

Xie, Xiaoliang; He, Yaqin; Li, Hai; Dong, Yu; Na, Li; Sun, Ting; Zhang, Dong; Shi, Xiaoyan; Xia, Yuhan; Jiang, Tao; Rong, Shikuo; Yang, Shaoqi; Ma, Xiaoqiang; Xu, Guofeng

doi:10.1016/j.nut.2018.10.038

Cited by 97 publications

(65 citation statements)

References 34 publications

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“…Eligible studies included those reporting effects of diets low or high in FODMAP ingredients on human intestinal microbiota composition in adults with intestinal diseases. A total of 15 studies [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] were withheld on this screening basis, some of which included diets of varying non-digestible carbohydrate content ( Figure 1). These included 13 randomized controlled trials, and 2 open-label studies, with one of the latter assessing multiple doses.…”

Section: Resultsmentioning

confidence: 99%

Effects of Low and High FODMAP Diets on Human Gastrointestinal Microbiota Composition in Adults with Intestinal Diseases: A Systematic Review

Vandeputte

Joossens

2020

Microorganisms

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A diet high in non-digestible carbohydrates is known to promote health, in part through its effect on the gut microbiome. While substantially proven for healthy individuals, these effects are more ambiguous in subjects with intestinal diseases. At the same time, a diet low in these fermentable carbohydrates, the low FODMAP (acronym for Fermentable Oligo-, Di-, Mono-saccharides, And Polyols) diet, is gaining popularity as a treatment option for symptom relief in irritable bowel syndrome and inflammatory bowel disease. There are, however, several indications that this diet induces effects opposite to those of prebiotic supplementation, resulting in gut microbiome changes that might be detrimental. Here, we provide a systematic review of the effects of low and high FODMAP diets on human gastrointestinal microbiota composition in adults with intestinal diseases, through literature screening using the databases PubMed, Embase, and Web of Science. We summarize study findings on dietary impact in patients, including the effect on bacterial taxa and diversity. In general, similar to healthy subjects, restricting non-digestible carbohydrate intake in patients with intestinal diseases has opposite effects compared to prebiotic supplementation, causing a reduction in bifidobacteria and an increase in bacteria associated with dysbiosis. Future studies should focus on assessing whether the induced microbial changes persist over time and have adverse effects on long-term colonic health.

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Section: Resultsmentioning

confidence: 99%

Effects of Low and High FODMAP Diets on Human Gastrointestinal Microbiota Composition in Adults with Intestinal Diseases: A Systematic Review

Vandeputte

Joossens

2020

Microorganisms

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“…In mice with CTX-induced immune suppression, ZQFZ enhanced the activities of NK cells, and regulated immune-related factors such as ILs and chemotactic factors. Immunoglobulins protect the body from infections and can enhance humoral immunity and the body's hematopoietic function [32,33]. Excessive production of ROS can affect the activity of in ammation-related proteins and damage the immune system [34].…”

Section: Discussionmentioning

confidence: 99%

ZhenQi FuZheng Formula Improves Mouse Hematopoietic Function after Cyclophosphamide-Induced Damage via Enhancing Macrophage Colony-Stimulating Factor Concentrations

Chu¹,

Dou²,

Wang³

et al. 2020

Preprint

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Background: Among the hematopoietic system, bone marrow has been recognized as the major source of hematopoietic progenitor cells (HPCs). Immuosuppression can inhibit the growth of bone marrow cells and cyclophosphamide (CTX) has been reported to induce myelosuppression. Regeneration of the immune system and hematopoietic function has become a primary problem in tumor adjuvant therapy. The present study investigated the effects of ZhenQi FuZheng formula (ZQFZ) on hematopoietic function in cells and murine models of cyclophosphamide(CTX)-induced immunosuppression and hematopoietic dysfunction. Methods: According to antibody chip analysis and enzyme-linked immunosorbent assay, ZQFZ regulated seven cytokines in serum and the spleen. Results: In Nrf2-siRNA transfected K562 cells, the regulatory effects of ZQFZ on the expression concentrations of macrophage colony-stimulating factor (M-CSF) and hematopoietic related proteins were strongly abolished. In immunosuppressed mice, ZQFZ enhanced the NK cell activities and regulated the concentrations of cytokines related to immune function. ZQFZ induced proliferation and differentiation, and upregulated the expression of hematopoietic-related proteins, including p90 ribosomal S6 kinases 1 (RSK1p90), c-Myc, and ETS transcription factor in CHRF and/or K562 cells. In mice with hematopoietic dysfunction, ZQFZ contributed to the recovery of blood cell concentrations in peripheral blood to normal values and enhanced the percentages of B lymphocytes (LYs) and juvenile cells in the bone marrow.Conclusions: In spleens of hematopoiesis damaged mice and primary cultured bone marrow cells, ZQFZ upregulated the expression concentrations of NF-E2-related Factor 2 (Nrf2) and its downstream proteins, and the activation of nuclear factor kappa-B. ZQFZ showed remarkably beneficial effects on the bone marrow hematopoietic system, at least partially, by enhancing the concentrations of M-CSF.

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“…In a randomized, double-blind trial involving 140 perioperative patients, decreased abundance of most gut flora induced by colorectal surgical stress were observed. Meanwhile, the abundance of some opportunistic pathogens and commensal microbiota increased (16). In our study, children in HOIS group underwent various surgeries, including intussusception, inguinal hernia repair, appendectomy and so on.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Surgery Contributes to Acute Cerebellar Ataxia Through Gut Brain Axis

Fan

Wang

et al. 2019

Front. Neurol.

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Introduction: Acute cerebellar ataxia (ACA) is the most common form of pediatric ataxia. Changes in gut flora can modulate the nervous system, influencing brain function via the gut-brain axis (GBA). This study aimed to illustrate the relationship between intestinal microbiota and ACA.Method: A total of 30 and 12 children were randomly sampled from history of intestinal surgery (HOIS) and no intestinal surgery groups (NHOIS), respectively. In addition, 10 healthy children who sought physical examination in Children's Hospital of Nanjing Medical University were recruited as a control group. The stool samples were 16S rRNA detected.Results: We observed that many ACA children had intestinal surgery history prior to the onset of ACA. The 16S rRNA sequencing indicated that HOIS and control groups were well-distinguished by principal component analysis. The discrepancy between HOIS and NHOIS groups were also displayed by principal component analysis score plot. However, no differences were found between NHOIS and control groups. The results of student's t-test were consistent with principal component analysis. A total of nine different genera were identified between HOIS and control groups. Five genera and a phylum showed significant differences between HOIS and NHOIS groups.Conclusion: Altered genera and phyla associated with ACA were identified. Our findings provide new insight into treating and preventing ACA.

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Effects of prebiotics on immunologic indicators and intestinal microbiota structure in perioperative colorectal cancer patients

Cited by 97 publications

References 34 publications

Effects of Low and High FODMAP Diets on Human Gastrointestinal Microbiota Composition in Adults with Intestinal Diseases: A Systematic Review

Effects of Low and High FODMAP Diets on Human Gastrointestinal Microbiota Composition in Adults with Intestinal Diseases: A Systematic Review

ZhenQi FuZheng Formula Improves Mouse Hematopoietic Function after Cyclophosphamide-Induced Damage via Enhancing Macrophage Colony-Stimulating Factor Concentrations

Intestinal Surgery Contributes to Acute Cerebellar Ataxia Through Gut Brain Axis

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