Effects of pre- and postnatal exposure to the UV-filter Octyl Methoxycinnamate (OMC) on the reproductive, auditory and neurological development of rat offspring

Axelstad, Marta; Boberg, Julie; Hougaard, Karin Sørig; Christiansen, Sofie; Jacobsen, Peter; Mandrup, Karen; Nellemann, Christine; Lund, Søren Peter; Hass, Ulla

doi:10.1016/j.taap.2010.10.031

Cited by 98 publications

(76 citation statements)

References 37 publications

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“…This was as expected, as reductions in prepubertal ventral prostate weights have been described after perinatal exposure to anti-androgens , Christiansen et al 2009, while the same effect of estrogens has been seen only at high dose levels. The estrogenic u.v.-filter OMC, which is present in the EMix and TotalMix, was found to reduce prepubertal ventral prostate weight only at a dose of 1000 mg/kg BW per day, which is 19 times higher than the dose applied in the highest mixture groups in this study (Axelstad et al 2011). In adult animals, estrogenic compounds may increase or decrease prostate weights depending on dose level (vom Saal et al 1997, Putz et al 2001.…”

Section: Discussioncontrasting

confidence: 48%

“…It may be speculated that a slight increasing effect in the anti-androgens on testis weight was counteracted by a slight depressing effect in the estrogenic components of the TotalMix on testis weight. A previous study showed increasing testis weights in 16-day-old male offspring following perinatal exposure to a mixture of anti-androgenic pesticides , and a study on the estrogenic u.v.-filter OMC showed reduced testis weight in males of the same age, following perinatal exposure (Axelstad et al 2011).…”

Section: Discussionmentioning

confidence: 88%

“…There is good evidence from animal studies that developmental exposure to environmental agents with endocrine-disrupting properties can cause adverse reproductive effects, including decreased anogenital distance (AGD), increased nipple retention (NR), altered weights and histopathology of reproductive organs, and reduced semen quality , Christiansen et al 2009, Axelstad et al 2011. The environmental agents that cause these effects often have many modes of action, but for simplicity, they are here described as being estrogenic or anti-androgenic.…”

Section: Introductionmentioning

confidence: 99%

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Mixtures of endocrine-disrupting contaminants induce adverse developmental effects in preweaning rats

et al. 2014

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Reproductive toxicity was investigated in rats after developmental exposure to a mixture of 13 endocrine-disrupting contaminants, including pesticides, plastic and cosmetic ingredients, and paracetamol. The mixture was composed on the basis of information about high-end human exposures, and the dose levels reflecting 100, 200, and 450 times this exposure were tested. The compounds were also grouped according to their estrogenicity or anti-androgenicity, and their joint effects were tested at two different doses, with each group reflecting 200 or 450 times human exposure. In addition, a single paracetamol dose was tested (350 mg/kg per day). All exposures and a vehicle were administered by oral gavage to time-mated Wistar dams rats throughout gestation and lactation, and their offspring were assessed for reproductive effects at birth and in prepuberty. The mixture doses, which included the anti-androgenic compounds, affected the male offspring by causing decreased anogenital distance, increased nipple retention (NR), and reduced ventral prostate weights, at both medium and high doses. In addition, the weights of the levator ani/bulbocavernosus muscle (LABC) were decreased at the high dose of anti-androgen mixture. No effects were seen after exposure to the estrogenic chemicals alone, whereas males exposed solely to paracetamol showed decreased LABC weights and increased NR. Thus adverse reproductive effects were observed at mixtures reflecting 200 times high-end human exposure, which is relatively close to the safety margin covered by the regulatory uncertainty factor of 100. This suggests that highly exposed human population groups may not be sufficiently protected against mixtures of endocrine-disrupting chemicals.

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Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Mixtures of endocrine-disrupting contaminants induce adverse developmental effects in preweaning rats

et al. 2014

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“…The increased use of OMC aggravated the potential risk [7,9] . It was reported that OMC inhibited the deiodinase activity [10] , induced morphological changes in the testes and ovaries of rats [11] , and affected secretion of estrogen, reproductive development and nervous system of rat offspring [12][13][14] . In the United States, European Union, and Australia, it was stipulated that the maximum dosage of OMC was 7.5-10% [15] .…”

mentioning

confidence: 99%

Preparation and Characterization of Microcapsules Encapsulating Octyl Methoxycinnamate by Complex Coacervation

Zhao¹

2016

ijps

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Zhao, et al.,: Octyl Methoxycinnamate-loaded MicrocapsulesThe aim of this study was to entrap the lipophilic ultraviolet absorber, octyl methoxycinnamate in microcapsuels to enhance its application. A complex coacervation method was established. Through the appearance of encapsulated glass beads prepared with different wall materials, gelatin and sodium polyphosphate were selected as wall materials because of dense structure and less adhesion. The effects of three variables, core/ (core+wall) ratio, pH at complex coacervation, and amount of cross-linking agent, on encapsulation efficiency were studied. Response surface methodology was employed to optimize the technology, and a polynomial regression model equation was generated. The optimization method enabled to predict the response variable value within the experimental range with good agreement between the predicted and experimental values. The microcapsules under the optimized conditions appeared spherical in shape with smooth nonporous surface and no tendency to aggregation. The photodegradation percentage of octyl methoxycinnamate after exposing to ultraviolet irradiation was determined and the transdermal permeation pattern of octyl methoxycinnamate and its photodegradation product from various formulations was estimated in vitro. From the results obtained, the microcapsules had achieved decreasing transdermal permeation of octyl methoxycinnamate and its photodegradation product, enhancing the accumulation of the sunscreen at the administration site, and then increasing the protection effect and safety. This study revealed the potential of sunscreen microcapsules as new skin drug delivery systems.

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“…EHMC has been the subject of significant debate regarding its accumulation in human tissue, and possible risks associated with potential endocrine-disrupting effects (Manová et al, 2015). Investigations on rats into the effects of exposure to high concentrations of EHMC showed a marked decrease in the levels of thyroid hormones, which could affect both reproductive and neurological development (Axelstad et al, 2011;Klammer et al, 2007). In addition to possible adverse effects of EHMC on human health, its widespread use in cosmetics has led to a ubiquitous presence in the aquatic environment.…”

Section: Synthetic Organic Uv Filtersmentioning

confidence: 99%

Cyanobacterial metabolites as a source of sunscreens and moisturizers: a comparison with current synthetic compounds

Derikvand

Llewellyn

Purton

2016

European Journal of Phycology

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Effects of pre- and postnatal exposure to the UV-filter Octyl Methoxycinnamate (OMC) on the reproductive, auditory and neurological development of rat offspring

Cited by 98 publications

References 37 publications

Mixtures of endocrine-disrupting contaminants induce adverse developmental effects in preweaning rats

Mixtures of endocrine-disrupting contaminants induce adverse developmental effects in preweaning rats

Preparation and Characterization of Microcapsules Encapsulating Octyl Methoxycinnamate by Complex Coacervation

Cyanobacterial metabolites as a source of sunscreens and moisturizers: a comparison with current synthetic compounds

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