Effects of praziquantel and artesunate on the tegument of adult Schistosoma mekongi harboured in mice

Jiraungkoorskul, Wannee; Sahaphong, Somphong; Sobhon, Prasert; Riengrojpitak, Suda; Kangwanrangsan, Niwat

doi:10.1016/j.parint.2005.04.001

Cited by 67 publications

(34 citation statements)

References 31 publications

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“…Therefore, the tegmental alteration in S. mansoni worms after treatment with black seed oil and/or algal extract could have exerted an intense effect on the meta-bolic activities of the parasite and in turn expose the tegument to the host's immune attack. Changes in the surface topography of Schistosoma worms were used by a number of investigators for the assessment of anti-Schistosoma drug actions, as the tegument is an important target for anti-Schistosoma drugs [18,25,46,47]. Moreover, the change caused by anti-Schistosoma drugs was more distinct in the male tegument than in that of the female, where most of the female's body is enclosed in the gynaecophoric duct of the male and it is not in direct contact with the host's microenvironment [53,55].…”

Section: Discussionmentioning

confidence: 99%

Schistosoma mansoni: Antiparasitic effects of orally administeredNigella sativaoil and/orChroococcus turgidusextract

Ali

Eldahab

Mansour

et al. 2016

Acta Biologica Hungarica

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Schistosoma mansoni is one of the parasites causing schistosomiasis, a disease which threatens millions of people all over the world. Traditional chemical drugs are not fully effective against schistosomaisis due to the evolving drug resistant worm strains, so exploring new remedies derived from natural products is a good way to fight schistosomiasis. In the present investigation two natural products, Nigella sativa oil and Chroococcus turgidus extract were used separately or in a combination to explore their effect on S. mansoni. The infected mice treated with Chroococcus turgidus extract or/and sativa seed oil showed a significant decrease in the total worm burden. The total number of deposited eggs by females of S. mansoni was significantly decreased in the liver of mice treated with Chroococcus turgidus extract or/and sativa seed oil. However, in the intestine, the number of eggs was significantly reduced in mice treated with algal extract and those treated with both algal extract and oil. Fecundity of female S. mansoni showed a significant decrease from mice treated with algal extract or/and sativa seed oil. According to SEM investigations the tegmental surface, oral and ventral suckers of worms also showed considerable changes; as the tubercles lost their spines, some are swollen and torn out. The suckers become edematous and enlarged while the tegmental surface is damaged due to the treatment with Chroococcus turgidus extract or/and sativa seed oil. In conclusion, the Nigella sativa oil and Chroococcus turgidus extract are promising natural compounds that can be used in fighting schistosomiasis.

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Section: Discussionmentioning

confidence: 99%

Schistosoma mansoni: Antiparasitic effects of orally administeredNigella sativaoil and/orChroococcus turgidusextract

Ali

Eldahab

Mansour

et al. 2016

Acta Biologica Hungarica

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“…11 Similar damaging effects were noted in Schistosoma mekongi, 12 and S. mansoni. 13 Small intestinal trematodes, heterophyids, were also fatally damaged.…”

Section: Introductionmentioning

confidence: 70%

“…12 Extensive tegumental erosions were described in S. mansoni. 13 These detrimental effects are quite similar to the effects seen in the present experiment.…”

mentioning

confidence: 99%

In Vitro Anthelmintic Activity of Artesunate Against the Cestode Raillietina Echinobothrida

Lalchhandama¹

2015

Int. Res. J. Pharm.

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Artesunate is an anti malarial compound discovered from the Chinese medicinal plant Artemisia annua. It has been proven to be the best drug not only in the treatment of malaria, but also of human schistosomiasis. It is also shown to be highly effective against human virus, trematodes and various cancer cells. This study is a further exploration on its pharmacological potential as an anti cestodal agent. The cestode, Raillietina echinobothrida Mégnin, were collected from fowls and treated with varying doses of artesunate, namely 1, 2, 5, 10 and 20 mg/ml. The anthelmintic activity was compared with that of the standard prescription drug albendazole. Artesunate showed higher anthelmintic activity than albendazole. Microscopic examination of the cestodes treated with drugs showed extensive structural damage, including surface erosion and destruction of the scolex. The findings suggest that artesunate is a potent drug that may be used for cestode infection.

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“…[12] and the effect of praziquantel on Fibricola seoulensis [13]. The functional roles of the tegumental surface are for attachment and nutrient uptake from the host [14]. It is possible that the worms were released from epithelial tissue of host small intestine when their tegument was damaged by anthelmintic medication.…”

Section: Discussionmentioning

confidence: 99%

“…It is possible that the worms were released from epithelial tissue of host small intestine when their tegument was damaged by anthelmintic medication. Also, the damage of the tegument along the worm body could impair and destroy the worm defense system, making it susceptible to the host immune system as one function of the tegumental is against immune invasion [14,15]. Subsequently, their tegument is an important target for anthelmintic drugs.…”

Section: Discussionmentioning

confidence: 99%

In vitro Effects of Some Thai Anthelmintic Plants on Mortality and Change of Tegumental Surface of Stellantchasmus falcatus

Buddhachat¹,

Chantima²

2012

J Bacteriol Parasitol

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IntroductionStellantchasmus falcatus, a species of fluke in the Family Heterophyidae, is a minute intestinal trematode of fish-eating birds and mammals. Human infections with this fluke have been reported in Hawaii [1], Philippines [2], Japan [3], Thailand [4] and Korea [5]. The S. falcatus metacercariae or infective stage is commonly found in freshwater fish such as Mugil sp. [5], Xenetodon cancila [6] and Dermogenus pusillus [7]. In Thailand, five species of flukes i.e. Haplorchis pummilio, H. taichui, H. yokogawai, S. falcatus and Centrocestus caninus were found responsible for human infections [8,9] due to the consumption of raw or undercook fish.Some medical properties of bitter cucumber (Mormordica charantia Linn.) include antiviral, antibacterial, anti-inflammatory, immunestimulant, insecticidal and anthelmintic properties. A bitter cucumber has been used to study about the anthelmintic activity on Ascaridia galli and Plasmodium berghei as antimalarial agent. A bitter cucumber (M. charantia Linn.) was shown that it was safe in experimental animals when ingested at low doses up to 2 months [10]. Previous study has confirmed that various preparations of papaya (Carica papaya Linn.) seeds can against helminthes effectively in vitro and in infected animals. Bioactive compounds responsible for the anthelmintic properties were ascribed to carpaine, carpasemine and benzyl isothiocyanate [11]. Most importantly, both papaya seeds and bitter cucumber fruits are cheap and easily available in tropical countries. However, there is no report that study regarding the effect of both extract of papaya seeds and bitter cucumber fruits on tegumetal surface of helminthes. Thus, this study is the first paper that study anthelmintic activity of both papaya seeds and bitter cucumber fruits on S. falcatus by observation under a Scanning Electron Microscope (SEM). Materials and Methods Preparation of the aqueous extract of papaya seeds and bitter cucumber fruitsThe aqueous extract of papaya seeds and bitter cucumber fruits were prepared according to the Thai Pharmacopoeia. Papaya seeds, 0.75 grams were dried and boiled in distilled water until the volume was 200 ml (3.75 mg/ml) then filtered through a sieved cloth to obtain a 100% stock solution. Twelve grams of bitter cucumber fruits was chopped and boiled in distilled water until the volume was 200 ml (60 mg/ml) and then filtered through a sieved cloth to get a 100% stock solution. The 100% stock solution was diluted in Tyrode's solution to give 12.5% and 50% concentration. Adult Stellantchasmus falcatus preparationThe chicks (Gallus gallus domesticus) were orally force fed with half-beaked fish (Dermogenus pusillus) infected with metacercariae of S. falcatus. Three days later, adult worms were collected from the small intestine of the chicks with Baremann's apparatus and washed with 0.85 % NaCl solution. The worms obtained were stored in Tyrode's solution. Experimental designThirty adult worms were individually incubated in Petri-dish containing 5 ml of Tyrode's solution, 12....

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Effects of praziquantel and artesunate on the tegument of adult Schistosoma mekongi harboured in mice

Cited by 67 publications

References 31 publications

Schistosoma mansoni: Antiparasitic effects of orally administeredNigella sativaoil and/orChroococcus turgidusextract

Schistosoma mansoni: Antiparasitic effects of orally administeredNigella sativaoil and/orChroococcus turgidusextract

In Vitro Anthelmintic Activity of Artesunate Against the Cestode Raillietina Echinobothrida

In vitro Effects of Some Thai Anthelmintic Plants on Mortality and Change of Tegumental Surface of Stellantchasmus falcatus

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