Effects of PR toxin on liver cells in culture

PR Toxin – Biosynthesis, Genetic Regulation, Toxicological Potential, Prevention and Control Measures: Overview and Challenges

“…These effects were largely due to an increase in capillary or microvascular permeability resulting in direct damages to blood vessels and organs such as lungs, heart, liver, and kidneys ( Chen et al, 1982 ). In addition, it was found to be cytotoxic and affect liver cell viability at a very low concentration in rat liver ( Aujard et al, 1979 ). Collectively, these data suggest that PR toxin was hepato-and nephrotoxic to mice.…”

“…However, the increased interest in the mycotoxin research during the last few years has drawn the scientific attention on evaluating their toxicity on human cell lines. Hitherto, PR toxin was reported to be cytotoxic in porcine and human cell lines ( Aujard et al, 1979 ; Lompe and von Milczewski, 1979 ). In this respect, Rasmussen et al (2011) determined the in vitro cytotoxicity of PR toxin extracted from fungal agar and maize silage.…”

PR Toxin – Biosynthesis, Genetic Regulation, Toxicological Potential, Prevention and Control Measures: Overview and Challenges

“…These effects were largely due to an increase in capillary or microvascular permeability resulting in direct damages to blood vessels and organs such as lungs, heart, liver, and kidneys ( Chen et al, 1982 ). In addition, it was found to be cytotoxic and affect liver cell viability at a very low concentration in rat liver ( Aujard et al, 1979 ). Collectively, these data suggest that PR toxin was hepato-and nephrotoxic to mice.…”

“…However, the increased interest in the mycotoxin research during the last few years has drawn the scientific attention on evaluating their toxicity on human cell lines. Hitherto, PR toxin was reported to be cytotoxic in porcine and human cell lines ( Aujard et al, 1979 ; Lompe and von Milczewski, 1979 ). In this respect, Rasmussen et al (2011) determined the in vitro cytotoxicity of PR toxin extracted from fungal agar and maize silage.…”

ブルーチーズ生産に用いられる<i>Penicillium</i> 属菌の分類学的位置ついてのβ-チューブリン部分塩基配列に基づく検討

“…Roquefortine C and mycophenolic acid are produced by P. roqueforti and P. carneum 3) , and exhibit very low toxicities 4) . PR toxin, which is produced only by P. roqueforti 3) , inhibits in vivo and/or in vitro protein synthesis and nucleic acid synthesis 5), 6) . Furthermore, several researchers have reported that PR toxin is both cytotoxic 6), 7) and mutagenic 8) .…”

PR Toxin – Biosynthesis, Genetic Regulation, Toxicological Potential, Prevention and Control Measures: Overview and Challenges

“…These effects were largely due to an increase in capillary or microvascular permeability resulting in direct damages to blood vessels and organs such as lungs, heart, liver, and kidneys ( Chen et al, 1982 ). In addition, it was found to be cytotoxic and affect liver cell viability at a very low concentration in rat liver ( Aujard et al, 1979 ). Collectively, these data suggest that PR toxin was hepato-and nephrotoxic to mice.…”

“…However, the increased interest in the mycotoxin research during the last few years has drawn the scientific attention on evaluating their toxicity on human cell lines. Hitherto, PR toxin was reported to be cytotoxic in porcine and human cell lines ( Aujard et al, 1979 ; Lompe and von Milczewski, 1979 ). In this respect, Rasmussen et al (2011) determined the in vitro cytotoxicity of PR toxin extracted from fungal agar and maize silage.…”

ブルーチーズ生産に用いられる<i>Penicillium</i> 属菌の分類学的位置ついてのβ-チューブリン部分塩基配列に基づく検討

“…Roquefortine C and mycophenolic acid are produced by P. roqueforti and P. carneum 3) , and exhibit very low toxicities 4) . PR toxin, which is produced only by P. roqueforti 3) , inhibits in vivo and/or in vitro protein synthesis and nucleic acid synthesis 5), 6) . Furthermore, several researchers have reported that PR toxin is both cytotoxic 6), 7) and mutagenic 8) .…”

PR Toxin – Biosynthesis, Genetic Regulation, Toxicological Potential, Prevention and Control Measures: Overview and Challenges

“…These effects were largely due to an increase in capillary or microvascular permeability resulting in direct damages to blood vessels and organs such as lungs, heart, liver, and kidneys ( Chen et al, 1982 ). In addition, it was found to be cytotoxic and affect liver cell viability at a very low concentration in rat liver ( Aujard et al, 1979 ). Collectively, these data suggest that PR toxin was hepato-and nephrotoxic to mice.…”

“…However, the increased interest in the mycotoxin research during the last few years has drawn the scientific attention on evaluating their toxicity on human cell lines. Hitherto, PR toxin was reported to be cytotoxic in porcine and human cell lines ( Aujard et al, 1979 ; Lompe and von Milczewski, 1979 ). In this respect, Rasmussen et al (2011) determined the in vitro cytotoxicity of PR toxin extracted from fungal agar and maize silage.…”

ブルーチーズ生産に用いられる<i>Penicillium</i> 属菌の分類学的位置ついてのβ-チューブリン部分塩基配列に基づく検討

“…Roquefortine C and mycophenolic acid are produced by P. roqueforti and P. carneum 3) , and exhibit very low toxicities 4) . PR toxin, which is produced only by P. roqueforti 3) , inhibits in vivo and/or in vitro protein synthesis and nucleic acid synthesis 5), 6) . Furthermore, several researchers have reported that PR toxin is both cytotoxic 6), 7) and mutagenic 8) .…”