Effects of powder flowability on die-fill properties in rotary compression

Yaginuma, Yoshihito; Ozeki, Yuichi; Kakizawa, Masaki; Gomi, Shuichi; Watanabe, Yoshihisa

doi:10.1016/s1773-2247(07)50037-7

Cited by 32 publications

(15 citation statements)

References 11 publications

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“…These results were also obtained by other researchers. 10,20 Although the absolute reduction in tablet weight is larger for DCP (90 mg versus 60 mg), the reduction in terms of percentage for the MCC powder was slightly larger (13.3 % versus 9 %), due to the better flowability of the DCP mixture (i.e. faster die filling), which was also observed by Mendez et al.…”

Section: Evaluation Of the Powder Characteristicssupporting

confidence: 56%

“…10,20 This effect combined with more material loss after filling due to higher centrifugal forces increased weight variability. Although no significant difference was observed between the absolute increase in weight variability, it should be mentioned that the overall weight variability for MCC tablets is higher than for DCP tablets (Table 2), which is linked to their powder flow properties.…”

Section: Weight Variabilitymentioning

confidence: 99%

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Reduction of tablet weight variability by optimizing paddle speed in the forced feeder of a high-speed rotary tablet press

Peeters

Beer

Vervaet

et al. 2014

Drug Development and Industrial Pharmacy

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Context: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing economic efficiency and parametric release.Objective: The aim of this study was to investigate the influence of paddle speeds and fill depth at different tableting speeds on the weight and weight variability of tablets. Materials and methods:Two excipients possessing different flow behavior, microcrystalline cellulose (MCC) and dibasic calcium phosphate dihydrate (DCP), were selected as model powders. Tablets were manufactured via a high speed rotary tablet press using design of experiments (DoE). During each experiment also the volume of powder in the forced feeder was measured.Results and discussion: Analysis of the DoE revealed that paddle speeds are of minor importance for tablet weight but significantly affect volume of powder inside the feeder in case of powders with excellent flowability (DCP). The opposite effect of paddle speed was observed for fairly flowing powders (MCC). Tableting speed played a role in weight and weight variability, whereas changing fill depth exclusively influenced tablet weight. Conclusion:The DoE approach allowed predicting the optimum combination of process parameters leading to minimum tablet weight variability. Monte Carlo simulations allowed assessing the probability to exceed the acceptable response limits if factor settings were varied around their optimum. This multi-dimensional combination and interaction of input variables leading to response criteria with acceptable probability reflected the design space.

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Section: Evaluation Of the Powder Characteristicssupporting

confidence: 56%

Section: Weight Variabilitymentioning

confidence: 99%

Reduction of tablet weight variability by optimizing paddle speed in the forced feeder of a high-speed rotary tablet press

Peeters

Beer

Vervaet

et al. 2014

Drug Development and Industrial Pharmacy

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“…This observation is consistent with literature [3,17,19,20]. At higher tableting speed, the die spends less time underneath the force feeder allowing a shorter filling time (at 40 rpm: 0.36 s, at 75 rpm: 0.19 s), thus less tablet mass is obtained.…”

Section: Effect Of Process Conditions and Materials Properties On Tablsupporting

confidence: 92%

“…This interaction shows that at a low turret speed (40 rpm), the particles filled into the dies and leaving the system can be refilled likewise with a low or high paddle wheel speed resulting in a negligible tablet mass difference. This observation was also made in experiments [19,20]. This observation is consistent with [21] though it was not described explicitly.…”

Section: Effect Of Process Conditions and Materials Properties On Tablsupporting

confidence: 79%

Numerical Analysis of the Die Filling Process Within a Pharmaceutical Tableting Machine

Hildebrandt

Gopireddy

Scherließ

et al. 2018

Chemie Ingenieur Technik

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One of the main benefits of numerical simulations is the ability to shed light on the underlying physics in unit operations. This advantage was exploited in this work to study the die filling process in a lab-scale pharmaceutical rotary tablet press. The die filling process with emphasis on mass holdup, mass flow rate, tablet mass, and API content in the dies is described in detail. Eventually a design of experiments provides a clear picture on the influence of process conditions and material properties on the tablet mass to improve the process understanding.

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“…Different mechanisms act simultaneously on the powder bed, which cannot be captured by the existing conventional techniques to measure and quantify powder flow. 30,[44][45][46] Since the capacity of a glidant is mainly expressed in moving material, it is possible that this property is more pronounced in the forced feeder, during actual die filling, then it is during the static flow measurements.…”

Section: Effect Of the Paddle Speedsmentioning

confidence: 99%

Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press

Peeters

Vanhoorne

Remon

2016

Drug Development and Industrial Pharmacy

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To refer to or to cite this work, please use the citation to the published version: Peeters E., Vanhoorne V., Vervaet C., Remon J.P. AbstractContext: The negative impact of magnesium stearate on the hardness of tablets is a wellknown phenomenon, but the influence of paddle movement in the forced feeder on the lubricant effect during tablet compression is often neglected.Objective: The purpose of this research was to investigate the influence of paddle speed in the forced feeder on tablet tensile strength. Materials and methods:Mixtures of microcrystalline cellulose and magnesium stearate (0.5%)were blended using different methods (low & high shear). After blending, the formulations were compressed into tablets. All parameters of the tableting cycle were kept constant except the speed of the paddles in the forced feeder. Results and discussion:The blending technique affected the sensitivity of the formulation to the paddle speed. The tensile strength of pure microcrystalline cellulose tablets didn't change in function of paddle speed, while tablets prepared by low shear mixing became softer at higher paddle speed. The tensile strength of tablets manufactured using the high-shear mixed blend was low and didn't vary in function of paddle speed, suggesting that overlubrication already occurred during the initial blending step. Furthermore, analysis of the machine parameters allowed evaluation of the influence of the paddles on the flowability, initial packing and compactability of the powder mixtures. Conclusion:The results elucidated that during manufacturing of tablets using magnesium stearate-containing blends care should not only be taken during the blending step prior to tableting, but also during the tableting process itself, as paddle speed can affect tablet tensile strength, a critical quality attribute.

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Effects of powder flowability on die-fill properties in rotary compression

Cited by 32 publications

References 11 publications

Reduction of tablet weight variability by optimizing paddle speed in the forced feeder of a high-speed rotary tablet press

Reduction of tablet weight variability by optimizing paddle speed in the forced feeder of a high-speed rotary tablet press

Numerical Analysis of the Die Filling Process Within a Pharmaceutical Tableting Machine

Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press

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