Effects of potential neurotoxic pesticides on hearing loss: A review

Gatto, Maria Pia; Fioretti, Marzia; Fabrizi, Giovanni; Gherardi, Monica; Strafella, Elisabetta; Santarelli, Lory

doi:10.1016/j.neuro.2014.03.009

Cited by 25 publications

(34 citation statements)

References 44 publications

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“…Occupational and laboratory studies provide some limited evidence of hearing loss and deficits in auditory-related function and morphology following high exposures to some pesticides [21]. Studies of farm workers, agricultural crop sprayers, and insecticide sprayers for mosquito control programs have reported hearing loss/ poorer scores on audiometric tests [48-51], hearing dysfunction [52], and self-reported reduced hearing capacity [53].…”

Section: Discussionmentioning

confidence: 99%

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Prenatal exposure to multiple pesticides is associated with auditory brainstem response at 9months in a cohort study of Chinese infants

Sturza

Silver

et al. 2016

Environment International

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Background Pesticides are associated with poorer neurodevelopmental outcomes, but little is known about the effects on sensory functioning. Methods Auditory brainstem response (ABR) and pesticide data were available for 27 healthy, full-term 9-month-old infants participating in a larger study of early iron deficiency and neurodevelopment. Cord blood was analyzed by gas chromatography-mass spectrometry for levels of 20 common pesticides. The ABR forward-masking condition consisted of a click stimulus (masker) delivered via ear canal transducers followed by an identical stimulus delayed by 8, 16, or 64 milliseconds (ms). ABR peak latencies were evaluated as a function of masker-stimulus time interval. Shorter wave latencies reflect faster neural conduction, more mature auditory pathways, and greater degree of myelination. Linear regression models were used to evaluate associations between total number of pesticides detected and ABR outcomes. We considered an additive or synergistic effect of poor iron status by stratifying our analysis by newborn ferritin (based on median split). Results Infants in the sample were highly exposed to pesticides; a mean of 4.1 pesticides were detected (range 0-9). ABR Wave V latency and central conduction time (CCT) were associated with the number of pesticides detected in cord blood for the 64ms and non-masker conditions. A similar pattern seen for CCT from the 8ms and 16ms conditions, although statistical significance was not reached. Increased pesticide exposure was associated with longer latency. The relation between number of pesticides detected in cord blood and CCT depended on the infant’s cord blood ferritin level. Specifically, the relation was present in the lower cord blood ferritin group but not the higher cord blood ferritin group. Conclusions ABR processing was slower in infants with greater prenatal pesticide exposure, indicating impaired neuromaturation. Infants with lower cord blood ferritin appeared to be more sensitive to the effects of prenatal pesticide exposure on ABR latency delay, suggesting an additive or multiplicative effect.

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Section: Discussionmentioning

confidence: 99%

“…There have been some reports of hearing loss and ototoxicity following pesticide exposure, but most of the evidence comes from animal or occupational case studies where high-level exposures are the norm [21]. One recent study found deficits in cochlear status in children exposed to organochlorine pesticides.…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to multiple pesticides is associated with auditory brainstem response at 9months in a cohort study of Chinese infants

Sturza

Silver

et al. 2016

Environment International

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“…En este contexto, la exposición a estos compuestos se ha asociado con diferentes efectos adversos, entre los que se encuentran insuficiencia respiratoria (Baldi et al 2014), neurotoxicidad (Gamlin et al 2007, Gatto et al 2014, efectos neurológicos (Moretto y Colosio 2011, Hargreaves 2012, reproductivos (Sengupta y Banerjee 2014), inmunotóxicos (Corsini et al 2013), genotóxicos (Bolognesi 2003, Naravaneni y Jamil 2007, Martínez-Valenzuela et al 2009, Sundaramoorthy et al 2016, teratogénicos o carcinógenos (Cocco et al 2005, Pamies et al 2014, entre otros.…”

Section: Introductionunclassified

Patrón De Uso De Plaguicidas Y Biomarcadores Bioquímicos en Una Población De Fumigadores Urbanos

Benítez-Trinidad

Herrera-Moreno

Xotlanihua-Gervacio

et al. 2018

Rev. Int. Contam. Ambie.

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Palabras clave: plaguicidas, colinesterasas, paraoxonasa RESUMEN Nayarit es uno de los estados con las tasas más altas de intoxicación por plaguicidas en México. Los fumigadores son una población vulnerable por el alto riesgo de exposición que conlleva su trabajo. El objetivo de este estudio fue evaluar el patrón de uso de estos compuestos, así como las actividades de colinesterasas y paraoxonasa 1 en fumigadores urbanos, en dos periodos de tiempo. Se realizó un estudio descriptivo y analítico, se aplicaron cuestionarios estructurados para conocer las características antropométricas de los trabajadores que se dedican a la fumigación, la frecuencia del uso de equipo de protección, la percepción del riesgo y el patrón de plaguicidas utilizados. La determinación de las actividades acetilcolinesterasa (AChE), butirilcolinesterasa (BuChE) y paraoxonasa 1 (AREasa y CMPAasa) se realizó por métodos espectrofotométricos. Los resultados indican que el género masculino es el que mayormente desempaña estas labores y que el 95.1 % no utilizan el equipo de protección recomendado. Los insecticidas organofosforados, piretroides y carbamatos son los más utilizados. En cuanto a las actividades enzimáticas, se observó una menor actividad de BuChE y AREasa en el primer periodo del estudio. Sobre la base de los resultados obtenidos, es necesario implementar estrategias de educación ambiental encaminadas a disminuir la exposición a plaguicidas y por ende los efectos adversos ocasionados por un mal uso y manejo de los mismos.Key words: pesticides, cholinesterases, paraoxonases ABSTRACT Nayarit is among the states with the highest rates of pesticide poisoning in Mexico. Sprayers are a vulnerable population due to the high risk of exposure that their job entails. The aim of this study was to gain insight into the current usage pattern of pesticides in fumigation activities, cholinesterases and paraoxonase activities in urban sprays in two different period of times. A descriptive and analytical study was conducted, structured questionnaires were applied to evaluate the anthropometric characteristics

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“…The occupational hearing loss has been mostly only attributed to noise although there are other agents that might contribute to its potentiation, among them pesticides [2][3][4][5][6][7][8][9][10] . Studies have linked exposure to otoagressives agents, noise and ototoxics, at higher frequencies above 8kHz, before the others [11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

“…Studies reported harmful effects of pesticides to peripheral and central auditory pathways and in which the organophosphates can also be responsible for neurotoxicity to the auditory system 2,3,5,6,7,10 .…”

Section: Introductionmentioning

confidence: 99%